CAS 74050-20-7

Hydrocortisone Aceponate

Description:

Hydrocortisone aceponate is a synthetic corticosteroid used primarily for its anti-inflammatory and immunosuppressive properties. It is characterized by its ability to reduce inflammation and alleviate symptoms associated with various skin conditions, such as eczema and psoriasis. The compound is a derivative of hydrocortisone, modified to enhance its potency and reduce systemic side effects. Hydrocortisone aceponate is typically formulated as a topical preparation, allowing for localized treatment with minimal systemic absorption. Its mechanism of action involves the inhibition of pro-inflammatory cytokines and the suppression of immune responses, which helps to control inflammation and promote healing. The substance is generally well-tolerated, but like all corticosteroids, it may have potential side effects, particularly with prolonged use. It is important to follow medical guidance when using hydrocortisone aceponate to ensure effective and safe treatment.

Formula: C₂₆H₃₆O₇

InChI: InChI=1/C26H36O7/c1-5-22(31)33-26(21(30)14-32-15(2)27)11-9-19-18-7-6-16-12-17(28)8-10-24(16,3)23(18)20(29)13-25(19,26)4/h12,18-20,23,29H,5-11,13-14H2,1-4H3/t18-,19-,20-,23+,24-,25-,26-/m0/s1

InChI key: InChIKey=MFBMYAOAMQLLPK-FZNHGJLXSA-N

SMILES: C(COC(C)=O)(=O)[C@]1(OC(CC)=O)[C@]2(C)[C@@](CC1)([C@]3([C@]([C@@H](O)C2)([C@]4(C)C(CC3)=CC(=O)CC4)[H])[H])[H]

Synonyms:

• (11Beta)-21-(Acetyloxy)-11-Hydroxy-3,20-Dioxopregn-4-En-17-Yl Propanoate
• (11β)-21-(Acetyloxy)-11-hydroxy-17-(1-oxopropoxy)pregn-4-ene-3,20-dione
• 11beta,17,21-Trihydroxy pregn-4-ene-3,20-dione 21-acetate 17-propionate
• Aceponate d'hydrocortisone
• Aceponate d'hydrocortisone [French]
• Aceponato de hidrocortisona
• Aceponato de hidrocortisona [Spanish]
• Cortacare
• Cortavance
• Cortisol 17-propionate 21-acetate
• Efficort
• Hydrocortisone 17-propionate 21-acetate
• Hydrocortisone-17-aceponate
• Hydrocortisoni aceponas
• Hydrocortisoni aceponas [Latin]
• Pregn-4-ene-3,20-dione, 21-(acetyloxy)-11-hydroxy-17-(1-oxopropoxy)-, (11β)-
• Retef
• Suniderma
• Unii-2340Up1L2G
• Hydrocortisone aceponate
• [(8S,9S,10R,11S,13S,14S,17R)-17-(2-acetyloxyethanoyl)-11-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] propanoate
• propionic acid [(8S,9S,10R,11S,13S,14S,17R)-17-(2-acetoxyacetyl)-11-hydroxy-3-keto-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] ester
• Hydrocortisonepropylacetate
• [(8S,9S,10R,11S,13S,14S,17R)-17-(2-acetyloxyacetyl)-11-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] propanoate

Hydrocortisoneaceponate

CAS: 74050-20-7

Formula: C₂₆H₃₆O₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 460.5598

Ref: IN-DA00FDMC

Hydrocortisone 17-propionate 21-acetate

CAS: 74050-20-7

Formula: C₆H₃₆O₇

Purity: ≥ 96.0%

Color and Shape: White to off-white or beige solid

Molecular weight: 460.56

Ref: 7W-GX5431

Hydrocortisone 17-Propionate 21-Acetate

CAS: 74050-20-7

Formula: C₂₆H₃₆O₇

Molecular weight: 460.57

Ref: 4Z-H-103074

Hydrocortisone aceponate

CAS: 74050-20-7

Hydrocortisone aceponate

Purity: ≥98%

Molecular weight: 460.56g/mol

Ref: 54-BUP11195

Hydrocortisone 17-propionate 21-acetate

Controlled Product

CAS: 74050-20-7

Formula: C₂₆H₃₆O₇

Color and Shape: White To Beige

Molecular weight: 460.56

Ref: 04-C14224040

Hydrocortisone 17-propionate 21-acetate 100 µg/mL in Acetonitrile

CAS: 74050-20-7

Formula: C₂₆H₃₆O₇

Color and Shape: Single Solution

Molecular weight: 460.56

Ref: 04-A14224040AL-100

Hydrocortisone aceponate

CAS: 74050-20-7

Purity: 98%

Molecular weight: 460.5669860839844

Ref: 10-F614801

Hydrocortisone aceponate

CAS: 74050-20-7

Hydrocortisone aceponate (Hydrocortisone 17-propionate 21-acetate) is an effective topical glucocorticoid used in the form of a cream to treat various skin

Formula: C₂₆H₃₆O₇

Purity: 98.12%

Color and Shape: Solid

Molecular weight: 460.56

Ref: TM-T32114

Hydrocortisone 17-Propionate 21-Acetate

Controlled Product

CAS: 74050-20-7

Applications A new topical hydrocortisone derivative with esterification in positions 17 and 21, inhibit the incorporation of [3H]thymidine in DNA in human skin fibroblasts less strongly than the halogenated glucocorticosteroids betamethasone 17-valerate and clobetasol 17-propionate. Glucocorticosteroid.
References Dooms-Goossens, A., et al.: Eur. J. Dermatol., 3, 713 (1993), Isaksson, M., et al.: Contact Dermatitis, 43, 41 (2000), Matura, M., et al.: Allergy, 55, 698 (2000),

Formula: C₂₆H₃₆O₇

Color and Shape: White To Beige

Molecular weight: 460.56

Ref: TR-H714628

Hydrocortisone 17-propionate 21-acetate

Controlled Product

CAS: 74050-20-7

Hydrocortisone 17-propionate 21-acetate is a synthetic corticosteroid, which is a chemically modified derivative of cortisol. This compound is synthesized through the esterification of hydrocortisone, which enhances its lipophilicity and subsequently its ability to penetrate cellular membranes. The mode of action of hydrocortisone 17-propionate 21-acetate involves interaction with glucocorticoid receptors, which translocate into the nucleus to modulate gene expression. This regulation results in decreased production of inflammatory cytokines and other mediators of inflammation.

Formula: C₂₆H₃₆O₇

Purity: Min. 90 Area-%

Color and Shape: Off-White Beige Powder

Molecular weight: 460.56 g/mol

Ref: 3D-FH23886

Hydrocortisone 17-Propionate 21-Acetate

CAS: 74050-20-7

Formula: C₂₆H₃₆O₇

Molecular weight: 460.56

Ref: ST-EA-CP-B25066