CAS 74050-98-9
:Ketanserin
Description:
Ketanserin is a pharmaceutical compound primarily recognized for its role as a selective antagonist of the serotonin 5-HT2A receptor. It is classified as an antihypertensive agent and has been investigated for its potential in treating various cardiovascular conditions. Ketanserin exhibits a unique mechanism of action by blocking serotonin receptors, which can lead to vasodilation and a subsequent reduction in blood pressure. The compound is typically administered in its salt form and is known for its moderate lipophilicity, allowing it to cross biological membranes effectively. In addition to its antihypertensive properties, Ketanserin has been studied for its effects on other neurotransmitter systems, which may contribute to its therapeutic profile. Its pharmacokinetics include oral bioavailability, and it is metabolized primarily in the liver. As with many medications, Ketanserin may have side effects, including dizziness, fatigue, and gastrointestinal disturbances. Overall, Ketanserin represents a significant compound in the realm of cardiovascular pharmacotherapy, with ongoing research into its broader applications.
Formula:C22H22FN3O3
InChI:InChI=1S/C22H22FN3O3/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16H,9-14H2,(H,24,29)
InChI key:InChIKey=FPCCSQOGAWCVBH-UHFFFAOYSA-N
SMILES:O=C1C=2C(NC(=O)N1CCN3CCC(C(=O)C4=CC=C(F)C=C4)CC3)=CC=CC2
Synonyms:- 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,4(1H,3H)-quinazolinedione
- Ketanserin
- Ketanserina
- Ketanserine
- Ketensin
- R 41468
- Suffrexal
- Vulketan Gel
- Ketanserinum [INN-Latin]
- UNII-97F9DE4CT4
- Ketaserin
- Ketanserin [USAN:INN:BAN]
- Ketanserina [INN-Spanish]
- 3-(2-(4-(p-Fluorobenzoyl)piperidino)ethyl)-2,4-(1H,3H)-quinazolinedione
- 2,4(1H,3H)-Quinazolinedione, 3-(2-(4-(4-fluorobenzoyl)-1-piperidinyl)ethyl)-
- Ketanserinum
- 2,4(1H,3H)-Quinazolinedione, 3-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-
- Ketanserine [INN-French]
- See more synonyms
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Ketanserin
CAS:Formula:C22H22FN3O3Purity:>98.0%(HPLC)(T)Color and Shape:White to Light yellow powder to crystalMolecular weight:395.433-(2-(4-(4-Fluorobenzoyl)Piperidin-1-Yl)Ethyl)Quinazoline-2,4(1H,3H)-Dione
CAS:3-(2-(4-(4-Fluorobenzoyl)Piperidin-1-Yl)Ethyl)Quinazoline-2,4(1H,3H)-DioneFormula:C22H22FN3O3Purity:95%Molecular weight:395.43Ketanserin
CAS:Ketanserin: quinazoline derivative, 5-HT2 receptor antagonist, may lower blood pressure and inhibit blood clots.Formula:C22H22FN3O3Purity:99.19% - 99.73%Color and Shape:SolidMolecular weight:395.4268Ketanserin
CAS:Applications An antihypertensive, with affinity for multiple GPCR receptors.
References Zhu, Y., et al.: Biol. Pharm. Bull., 32, 1173 (2009), Shen, K., et al.: J. Pharm. Pharmacol., 61, 517 (2009), Brea, J., et al.: Mol. Pharmacol., 75, 1380 (2009), Varma, M., et al.: J. Med. Chem., 52, 4844 (2009),Formula:C22H22FN3O3Color and Shape:NeatMolecular weight:395.43Ketanserin
CAS:5-HT2A serotonin receptor antagonist; anti-hypertensiveFormula:C22H22FN3O3Purity:Min. 95%Molecular weight:395.43 g/molKetanserin
CAS:3-(2-(4-(4-Fluorobenzoyl)piperidin-1-yl)ethyl)quinazoline-2,4(1H,3H)-dioneFormula:C22H22FN3O3Purity:99%Molecular weight:395.43Kentanserin
CAS:M05722 - Kentanserin
Formula:C22H22FN3O3Purity:99%Color and Shape:SolidMolecular weight:395.434
