CAS 740816-86-8

Benzamide, N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-hydroxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl-

Description:

Benzamide, N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-hydroxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl- is a complex organic compound characterized by its intricate structure, which includes multiple fused ring systems and functional groups. The presence of a benzamide moiety indicates that it contains an amide functional group attached to a benzene ring, contributing to its potential biological activity. The stereochemistry, denoted by the specific configurations at various chiral centers, suggests that the compound may exhibit unique interactions in biological systems. Its hexahydro and epoxy groups imply potential reactivity and stability under certain conditions. The compound's molecular weight, solubility, and melting point would depend on its specific structural features, influencing its behavior in various chemical environments. Given its complexity, this substance may be of interest in medicinal chemistry, particularly in the development of pharmaceuticals or as a research tool in biochemical studies.

Formula: C₃₄H₂₈N₄O₄

Synonyms:

• O-Desmethyl PKC412
• O-Desmethyl Midostaurin (CGP62221)
• Benzamide, N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-hydroxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl-
• Midostaurin Impurity 2 (O-Desmethyl Midostaurin)
• CGP62221
• O-Desmethyl Midostaurin

O-Desmethyl Midostaurin-d5 (CGP62221-d5)

CAS: 740816-86-8

Formula: C₃₄H₂₃D₅N₄O₄

Molecular weight: 561.65

Ref: 4Z-M-160006

O-Desmethyl Midostaurin (CGP62221)

CAS: 740816-86-8

Formula: C₃₄H₂₈N₄O₄

Color and Shape: Pale Yellow Solid

Molecular weight: 556.62

Ref: 4Z-M-160003

O-Desmethyl Midostaurin-13C6

Controlled Product

CAS: 740816-86-8

Applications O-Desmethyl Midostaurin-13C6 is the labelled analogue of O-Desmethyl Midostaurin (D291400), a metabolite of Midostaurin (M343760), a compound shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit.
References Tahtouh, T., et al.: J. Med. Chem., 55, 9312 (2012); Pedeboscq, S., et al.: PLoS. One., 7, 36811 (2012);

Formula: C₂₈₁₃C₆H₂₈N₄O₄

Color and Shape: Neat

Molecular weight: 562.57

Ref: TR-D291402

O-Desmethyl Midostaurin

CAS: 740816-86-8

Stability Hygroscopic
Applications O-Desmethyl Midostaurin is a metabolite of Midostaurin (M343760), a compound shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit.
References Tahtouh, T., et al.: J. Med. Chem., 55, 9312 (2012); Pedeboscq, S., et al.: PLoS. One., 7, 36811 (2012);

Formula: C₃₄H₂₈N₄O₄

Color and Shape: Neat

Molecular weight: 556.61

Ref: TR-D291400

O-Desmethyl Midostaurin-d5

Controlled Product

CAS: 740816-86-8

Applications O-Desmethyl Midostaurin-d5 is a deuterium labelled derivative of O-Desmethyl Midostaurin (D291400(M)). O-Desmethyl Midostaurin is a metabolite of Midostaurin (M343760), a compound shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit. O-Desmethyl Midostaurini is also an active metabolite involved in cytochrome P450 liver enzyme metabolism.
References Tahtouh, T., et al.: J. Med. Chem., 55, 9312 (2012); Pedeboscq, S., et al.: PLoS. One., 7, 36811 (2012); Levis, M., et al.: NLM, 108, 3477 (2006)

Formula: C₃₄D₅H₂₃N₄O₄

Color and Shape: Neat

Molecular weight: 561.641

Ref: TR-D291401

o-Desmethyl midostaurin-13C6

CAS: 740816-86-8

Midostaurin is a therapeutic agent for the treatment of chronic myeloid leukemia. It belongs to the family of inhibitors that bind to ion channels and inhibit their activity. The drug has been shown to be an inhibitor of potassium channels, calcium channels, and sodium channels. Midostaurin has been found to bind to the receptor activator of nuclear factor kappa-B ligand (RANKL) on cells in culture, which may contribute to its anti-inflammatory effects.

Formula: C₃₄H₂₈N₄O₄

Purity: Min. 95%

Molecular weight: 556.6 g/mol

Ref: 3D-QEB81686

O-Desmethyl Midostaurin

CAS: 740816-86-8

Formula: C₃₄H₂₈N₄O₄

Molecular weight: 556.62

Ref: ST-EA-CP-M107001

O-Desmethyl Midostaurin

CAS: 740816-86-8

O-Desmethyl Midostaurin is the active Midostaurin metabolite via cytochrome P450 liver enzyme metabolism.

Formula: C₃₄H₂₈N₄O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 556.61

Ref: TM-T12280