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CAS 7414-83-7

:

Etidronate disodium

Description:
Agents in the first generation (e.g., etidronate disodium and tiludronate) that were dosed continuously produced poorly mineralized bone, because there was no interval for appropriate bone mineralization to occur. Subsequent studies that used a cyclic dosing schedule (400 mg/day for 2 weeks, followed by 2.5 months of calcium supplementation only) showed improvement in bone mineralization. Etidronate has been approved for treatment of Paget's disease of the bone but not for treatment of osteoporosis. Tiludronate is approximately 10-fold more potent than etidronate and, when given orally for 6 months (200, 400, or 800 mg/day), increases BMD by 2%. No further bone loss was detected in patients 6 months after cessation of therapy.
Formula:C2H6Na2O7P2
InChI:InChI=1/C2H8O7P2.2Na/c1-2(3,10(4,5)6)11(7,8)9;;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-4
InChI key:InChIKey=FCBYKAIUKRZZGW-UHFFFAOYSA-N
SMILES:C(P(=O)(O)O)(P(=O)(O)O)(C)O.[Na]
Synonyms:
  • (1-Hydroxyethane-1,1-Diyl)Di-Phosphonic Aci Disodium Salt
  • (1-Hydroxyethylidene)Bis-Phosphonic Aci Disodium Salt
  • (1-Hydroxyethylidene)Diphosphonic Acid, Disodium Salt
  • (1-Hydroxyethylidene)bisphosphonic acid disodium salt
  • 1-Hydroxyethane-1,1-Diyl)Diphosphonic Acid Disodium Salt
  • 1-Hydroxyethane-1,1-diphosphonic acid disodium salt
  • 1-Hydroxyethylidene)Di-Phosphonic Aci Disodium Salt
  • 1-Hydroxyethylidene-1,1-Diphosphonic Acid Disodium Salt
  • 1-Hydroxyethylidene-Bis-Phosphonic Acid, Disodium Salt
  • Ba 49280E
  • See more synonyms
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