CAS 74150-27-9
:Pimobendan
Description:
Pimobendan is a pharmaceutical compound primarily used in veterinary medicine, particularly for the treatment of congestive heart failure in dogs. It functions as a positive inotropic agent, enhancing the heart's contractility, and also acts as a vasodilator, which helps to reduce the workload on the heart. The chemical structure of pimobendan includes a benzazepine core, and it is classified as a phosphodiesterase III inhibitor, which contributes to its mechanism of action by increasing intracellular cyclic AMP levels. This results in improved cardiac output and reduced pulmonary congestion. Pimobendan is typically administered orally and is well-absorbed, with a relatively long half-life, allowing for once or twice daily dosing. Its safety profile is generally favorable, although potential side effects may include gastrointestinal disturbances and arrhythmias. As a veterinary medication, it is crucial to use pimobendan under the guidance of a veterinarian to ensure appropriate dosing and monitoring of the animal's response to treatment.
Formula:C19H18N4O2
InChI:InChI=1S/C19H18N4O2/c1-11-9-17(24)22-23-18(11)13-5-8-15-16(10-13)21-19(20-15)12-3-6-14(25-2)7-4-12/h3-8,10-11H,9H2,1-2H3,(H,20,21)(H,22,24)
InChI key:InChIKey=GLBJJMFZWDBELO-UHFFFAOYSA-N
SMILES:CC1C(C=2C=C3C(N=C(N3)C4=CC=C(OC)C=C4)=CC2)=NNC(=O)C1
Synonyms:- (±)-Ud Cg 115Bs
- 2-(4-methoxyphenyl)-5(6)-(5-methyl-3-oxo-4,5-dihydro-2H-6-pyridazinyl)benzimidazole
- 3(2H)-pyridazinone, 4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-
- 3(2H)-pyridazinone, 4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-5-methyl-
- 4,5-Dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-3(2H)-pyridazinone
- 4,5-Dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-5-methyl-3(2H)-pyridazinone
- 6-[2-(4-Methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-4,5-dihydropyridazin-3(2H)-one
- 6-[2-(4-Methoxyphenyl)-1H-benzimidazol-6-yl]-5-methyl-4,5-dihydropyridazin-3(2H)-one
- Acardi
- Pimobenda
- Racemic pimobendan
- Ud Cg 115 Bs
- Ud-Cg 115
- Vetmedin
- See more synonyms
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Found 16 products.
Pimobendan
CAS:PimobendanFormula:C19H18N4O2Purity:99.5%Color and Shape:WhiteMolecular weight:334.14298Pimobendan
CAS:Drugs with nitrogen hetero-atom(s) only, aromatic or modified aromatic, nesoiFormula:C19H18N4O2Color and Shape:White Yellow PowderMolecular weight:334.14298Pimobendan
CAS:Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 (IC50: 0.32 μM).Formula:C19H18N4O2Purity:99.91%Color and Shape:SolidMolecular weight:334.376-(2-(4-Methoxyphenyl)-1H-Benzo[D]Imidazol-5-Yl)-5-Methyl-4,5-Dihydropyridazin-3(2H)-One
CAS:6-(2-(4-Methoxyphenyl)-1H-Benzo[D]Imidazol-5-Yl)-5-Methyl-4,5-Dihydropyridazin-3(2H)-OneFormula:C19H18N4O2Purity:99%Color and Shape: white to almost white crsytal to powderMolecular weight:334.37g/molPimobendan
CAS:Formula:C19H18N4O2Purity:>98.0%(T)(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:334.38Pimobendan 100 µg/mL in Acetonitrile
CAS:Formula:C19H18N4O2Color and Shape:Single SolutionMolecular weight:334.37Pimobendan-d3
CAS:Controlled ProductApplications Pimobendan-d3, is the labeled analogue of Pimobendan (P447500), a cardiotonic agent.
References Yokota, S. et al.: Yakuri Chiryo, 20, 1143 (1992); Yamamoto, M. et al.: Kank. Igaku Ken. Nenpo, 47, 155 (1996); Matsumoto, A. et al.: Cardiovas. Drugs Ther., 12, 595 (1998);Formula:C19H15D3N4O2Color and Shape:NeatMolecular weight:337.39rac Pimobendan
CAS:Controlled ProductApplications Pimobendan is a cardiotonic agent. The study of the cardiotonic mechanism of Pimobendan using ventricular muscles from rabbits and guinea pigs suggests that Pimobendan acts by inhibiting phosphodiesterase III and potassium channel. The potent venodilating action of Pimobendan makes it a suitable treatment option for patients with congestive heart failure (CHF) as it also improves systemic vasoconstriction.
References Yokota, S. et al.: Yakuri Chiryo, 20, 1143 (1992); Yamamoto, M. et al.: Kank. Igaku Ken. Nenpo, 47, 155 (1996); Matsumoto, A. et al.: Cardiovas. Drugs Ther., 12, 595 (1998);Formula:C19H18N4O2Color and Shape:NeatMolecular weight:334.37Pimobendan
CAS:Pimobendan is a drug that has been shown to have positive effects on the cardiac function of experimental animals. It is a selective inhibitor of the enzyme phosphodiesterase 3 in cardiac tissues. Pimobendan also has effects on blood pressure, as it increases systolic pressure and decreases diastolic pressure. The pharmacokinetic properties of pimobendan are characterized by a concentration-time curve with a long terminal half-life. Pimobendan is also an ATP-sensitive K+ channel blocker, which causes increased intracellular K+ concentrations in the myocardium. This leads to an increase in cardiac contractility and relaxation, with an improvement in cardiac performance. Chronic oral administration of pimobendan has been shown to be effective in improving the long-term efficacy of treatment for congestive heart failure due to chronic valvular disease or dilated cardiomyopathy.Formula:C19H18N4O2Purity:Min. 95%Color and Shape:White PowderMolecular weight:334.37 g/mol
![6-(2-(4-Methoxyphenyl)-1H-Benzo[D]Imidazol-5-Yl)-5-Methyl-4,5-Dihydropyridazin-3(2H)-One](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F54%2Fthumb%2FOR1011940.jpg&w=3840&q=75)
