CAS 74150-27-9
:Pimobendan
Description:
Pimobendan is a pharmaceutical compound primarily used in veterinary medicine, particularly for the treatment of congestive heart failure in dogs. It functions as a positive inotropic agent, enhancing the heart's contractility, and also acts as a vasodilator, which helps to reduce the workload on the heart. The chemical structure of pimobendan includes a benzazepine core, and it is classified as a phosphodiesterase III inhibitor, which contributes to its mechanism of action by increasing intracellular cyclic AMP levels. This results in improved cardiac output and reduced pulmonary congestion. Pimobendan is typically administered orally and is well-absorbed, with a relatively long half-life, allowing for once or twice daily dosing. Its safety profile is generally favorable, although potential side effects may include gastrointestinal disturbances and arrhythmias. As a veterinary medication, it is crucial to use pimobendan under the guidance of a veterinarian to ensure appropriate dosing and monitoring of the animal's response to treatment.
Formula:C19H18N4O2
InChI:InChI=1S/C19H18N4O2/c1-11-9-17(24)22-23-18(11)13-5-8-15-16(10-13)21-19(20-15)12-3-6-14(25-2)7-4-12/h3-8,10-11H,9H2,1-2H3,(H,20,21)(H,22,24)
InChI key:InChIKey=GLBJJMFZWDBELO-UHFFFAOYSA-N
SMILES:CC1C(C=2C=C3C(N=C(N3)C4=CC=C(OC)C=C4)=CC2)=NNC(=O)C1
Synonyms:- (±)-Ud Cg 115Bs
- 2-(4-methoxyphenyl)-5(6)-(5-methyl-3-oxo-4,5-dihydro-2H-6-pyridazinyl)benzimidazole
- 3(2H)-pyridazinone, 4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-
- 3(2H)-pyridazinone, 4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-5-methyl-
- 4,5-Dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-3(2H)-pyridazinone
- 4,5-Dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-5-methyl-3(2H)-pyridazinone
- 6-[2-(4-Methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-4,5-dihydropyridazin-3(2H)-one
- 6-[2-(4-Methoxyphenyl)-1H-benzimidazol-6-yl]-5-methyl-4,5-dihydropyridazin-3(2H)-one
- Acardi
- Pimobenda
- Racemic pimobendan
- Ud Cg 115 Bs
- Ud-Cg 115
- Vetmedin
- See more synonyms
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Pimobendan
CAS:PimobendanFormula:C19H18N4O2Purity:99.5%Color and Shape:White. To. Off-WhiteMolecular weight:334.14298Pimobendan
CAS:Drugs with nitrogen hetero-atom(s) only, aromatic or modified aromatic, nesoiFormula:C19H18N4O2Color and Shape:White Yellow PowderMolecular weight:334.14298Pimobendan
CAS:Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 (IC50: 0.32 μM).Formula:C19H18N4O2Purity:99.91%Color and Shape:White SolidMolecular weight:334.376-(2-(4-Methoxyphenyl)-1H-Benzo[D]Imidazol-5-Yl)-5-Methyl-4,5-Dihydropyridazin-3(2H)-One
CAS:6-(2-(4-Methoxyphenyl)-1H-Benzo[D]Imidazol-5-Yl)-5-Methyl-4,5-Dihydropyridazin-3(2H)-OneFormula:C19H18N4O2Purity:99%Color and Shape:White SolidMolecular weight:334.376-(2-(4-Methoxyphenyl)-1H-Benzo[D]Imidazol-5-Yl)-5-Methyl-4,5-Dihydropyridazin-3(2H)-One
CAS:Formula:C19H18N4O2Purity:98%Color and Shape:SolidMolecular weight:334.3718Pimobendan 100 µg/mL in Acetonitrile
CAS:Formula:C19H18N4O2Color and Shape:Single SolutionMolecular weight:334.37Pimobendan
CAS:Formula:C19H18N4O2Purity:>98.0%(T)(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:334.38Pimobendan
CAS:6-(2-(4-Methoxyphenyl)-1H-benzo[d]imidazol-5-yl)-5-methyl-4,5-dihydropyridazin-3(2H)-oneFormula:C19H18N4O2Purity:98%Molecular weight:334.37rac Pimobendan
CAS:Controlled ProductApplications Pimobendan is a cardiotonic agent. The study of the cardiotonic mechanism of Pimobendan using ventricular muscles from rabbits and guinea pigs suggests that Pimobendan acts by inhibiting phosphodiesterase III and potassium channel. The potent venodilating action of Pimobendan makes it a suitable treatment option for patients with congestive heart failure (CHF) as it also improves systemic vasoconstriction.
References Yokota, S. et al.: Yakuri Chiryo, 20, 1143 (1992); Yamamoto, M. et al.: Kank. Igaku Ken. Nenpo, 47, 155 (1996); Matsumoto, A. et al.: Cardiovas. Drugs Ther., 12, 595 (1998);Formula:C19H18N4O2Color and Shape:NeatMolecular weight:334.37Pimobendan-d3
CAS:Controlled ProductApplications Pimobendan-d3, is the labeled analogue of Pimobendan (P447500), a cardiotonic agent.
References Yokota, S. et al.: Yakuri Chiryo, 20, 1143 (1992); Yamamoto, M. et al.: Kank. Igaku Ken. Nenpo, 47, 155 (1996); Matsumoto, A. et al.: Cardiovas. Drugs Ther., 12, 595 (1998);Formula:C19H15D3N4O2Color and Shape:NeatMolecular weight:337.39
![6-(2-(4-Methoxyphenyl)-1H-Benzo[D]Imidazol-5-Yl)-5-Methyl-4,5-Dihydropyridazin-3(2H)-One](https://static.cymitquimica.com/products/IN/thumb/DA00FA4E.jpg)
