CAS 74150-27-9

Pimobendan

Description:

Pimobendan is a pharmaceutical compound primarily used in veterinary medicine, particularly for the treatment of congestive heart failure in dogs. It functions as a positive inotropic agent, enhancing the heart's contractility, and also acts as a vasodilator, which helps to reduce the workload on the heart. The chemical structure of pimobendan includes a benzazepine core, and it is classified as a phosphodiesterase III inhibitor, which contributes to its mechanism of action by increasing intracellular cyclic AMP levels. This results in improved cardiac output and reduced pulmonary congestion. Pimobendan is typically administered orally and is well-absorbed, with a relatively long half-life, allowing for once or twice daily dosing. Its safety profile is generally favorable, although potential side effects may include gastrointestinal disturbances and arrhythmias. As a veterinary medication, it is crucial to use pimobendan under the guidance of a veterinarian to ensure appropriate dosing and monitoring of the animal's response to treatment.

Formula: C₁₉H₁₈N₄O₂

InChI: InChI=1S/C19H18N4O2/c1-11-9-17(24)22-23-18(11)13-5-8-15-16(10-13)21-19(20-15)12-3-6-14(25-2)7-4-12/h3-8,10-11H,9H2,1-2H3,(H,20,21)(H,22,24)

InChI key: InChIKey=GLBJJMFZWDBELO-UHFFFAOYSA-N

SMILES: CC1C(C=2C=C3C(N=C(N3)C4=CC=C(OC)C=C4)=CC2)=NNC(=O)C1

Synonyms:

• (±)-Ud Cg 115Bs
• 2-(4-methoxyphenyl)-5(6)-(5-methyl-3-oxo-4,5-dihydro-2H-6-pyridazinyl)benzimidazole
• 3(2H)-pyridazinone, 4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-
• 3(2H)-pyridazinone, 4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-5-methyl-
• 4,5-Dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-3(2H)-pyridazinone
• 4,5-Dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-5-methyl-3(2H)-pyridazinone
• 6-[2-(4-Methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-4,5-dihydropyridazin-3(2H)-one
• 6-[2-(4-Methoxyphenyl)-1H-benzimidazol-6-yl]-5-methyl-4,5-dihydropyridazin-3(2H)-one
• Acardi
• Pimobenda
• Racemic pimobendan
• Ud Cg 115 Bs
• Ud-Cg 115
• Vetmedin

Pimobendan

CAS: 74150-27-9

Purity: 99%

Molecular weight: 334.3789978

Ref: 10-F863694

Pimobendan

CAS: 74150-27-9

Formula: C₁₉H₁₈N₄O₂

Molecular weight: 334.38

Ref: ST-EA-CP-P90000

Pimobendan

CAS: 74150-27-9

Pimobendan is a drug that has been shown to have positive effects on the cardiac function of experimental animals. It is a selective inhibitor of the enzyme phosphodiesterase 3 in cardiac tissues. Pimobendan also has effects on blood pressure, as it increases systolic pressure and decreases diastolic pressure. The pharmacokinetic properties of pimobendan are characterized by a concentration-time curve with a long terminal half-life. Pimobendan is also an ATP-sensitive K+ channel blocker, which causes increased intracellular K+ concentrations in the myocardium. This leads to an increase in cardiac contractility and relaxation, with an improvement in cardiac performance. Chronic oral administration of pimobendan has been shown to be effective in improving the long-term efficacy of treatment for congestive heart failure due to chronic valvular disease or dilated cardiomyopathy.

Formula: C₁₉H₁₈N₄O₂

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 334.37 g/mol

Ref: 3D-FP38260