CAS 7481-89-2: Dideoxycytidine
Description:Dideoxycytidine, also known as ddC or zalcitabine, is a synthetic nucleoside analog of cytidine, primarily used as an antiviral medication in the treatment of HIV/AIDS. Its chemical structure features a modified sugar moiety, lacking the 2' and 3' hydroxyl groups, which renders it unable to participate in DNA chain elongation during replication. This characteristic makes it an effective inhibitor of viral reverse transcriptase, thereby preventing the replication of the virus. Dideoxycytidine is typically administered orally and is known for its potential side effects, including peripheral neuropathy and lactic acidosis. The compound is classified as a nucleoside reverse transcriptase inhibitor (NRTI) and is often used in combination with other antiretroviral agents to enhance therapeutic efficacy and reduce the risk of resistance. Its pharmacokinetics involve rapid absorption and distribution, with metabolism primarily occurring in the liver. Overall, dideoxycytidine represents an important tool in the management of HIV infection, contributing to improved patient outcomes when used appropriately.
Formula:C9H13N3O3
InChI:InChI=1S/C9H13N3O3/c10-7-3-4-12(9(14)11-7)8-2-1-6(5-13)15-8/h3-4,6,8,13H,1-2,5H2,(H2,10,11,14)/t6-,8+/m0/s1
InChI key:InChIKey=WREGKURFCTUGRC-POYBYMJQSA-N
SMILES:O=C1N=C(N)C=CN1C2OC(CO)CC2
- Synonyms:
- 1-(2',3'-Dideoxy-Beta-Ribofuranosyl)Cytosine
- 2,3-Didesoxycytidine
- 2’,3’-Dideoxy-Cytidin
- 2′,3′-Dideoxycytidine
- 4-Amino-1-[(2R,5S)-5-(Hydroxymethyl)Oxolan-2-Yl]Pyrimidin-2-One
- 4-amino-1-[(5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-one
- 4-amino-1-[5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-one
- Beta-D-2',3'-Dideoxycytidine
- Cytidine, 2',3'-dideoxy-
- Cytidine, 2′,3′-dideoxy-
- See more synonyms
- D 2C
- DDC
- Dideoxycytidine
- Hivid
- Nsc 606170
- Ro 24-2027/000
- Zalcitabine
