CAS 75-89-8

2,2,2-Trifluoroethanol

Description:

2,2,2-Trifluoroethanol (CAS 75-89-8) is a colorless, volatile liquid that is characterized by its strong hydrogen bonding capabilities due to the presence of a hydroxyl (-OH) group. This compound features three fluorine atoms attached to the second carbon of the ethyl group, which significantly influences its physical and chemical properties. It has a relatively high boiling point compared to other alcohols of similar molecular weight, attributed to the electronegative fluorine atoms that enhance intermolecular interactions. 2,2,2-Trifluoroethanol is known for its polar nature, making it a useful solvent in various chemical reactions, particularly in organic synthesis and for dissolving polar compounds. It is also utilized in the pharmaceutical industry and in the preparation of fluorinated compounds. However, it is important to handle this substance with care, as it can be irritating to the skin and eyes, and its vapors may be harmful if inhaled. Proper safety measures should be observed when working with this chemical.

Formula: C₂H₃F₃O

InChI: InChI=1S/C2H3F3O/c3-2(4,5)1-6/h6H,1H2

InChI key: InChIKey=RHQDFWAXVIIEBN-UHFFFAOYSA-N

SMILES: C(CO)(F)(F)F

Synonyms:

• 1,1,2-Trifluoroethanol
• 2,2,2-Trifluoraethanol
• 2,2,2-Trifluorethanol
• 2,2,2-Trifluoroetanol
• 2,2,2-Trifluoroethan-1-ol
• 2,2,2-Trifluoroethyl alcohol
• Chloro(Difluoro)Acetic Acid
• Ethanol, 2,2,2-trifluoro-
• Nsc 451
• TFE
• Trifluoroethanol
• Trifluroroethyl alchohol
• β,β,β-Trifluoroethyl alcohol

2,2,2-Trifluoroethanol [for HPLC]

CAS: 75-89-8

Formula: C₂H₃F₃O

Purity: >99.0%(GC)

Color and Shape: Colorless to Almost colorless clear liquid

Molecular weight: 100.04

Ref: 3B-T4174

2,2,2-Trifluoroethanol

CAS: 75-89-8

Formula: C₂H₃F₃O

Purity: >99.0%(GC)

Color and Shape: Colorless to Almost colorless clear liquid

Molecular weight: 100.04

Ref: 3B-T0435

2,2,2-Trifluoroethanol, 99+%

CAS: 75-89-8

Trifluoroethanol serves as a solvent and a raw material in organic chemistry and biology. TFE is a solvent of choice for hydrogen peroxide-mediated oxidations of sulfides. Trifluoroethanol acts as a protein denaturant. It is used in the manufacture of certain pharmaceuticals and drug substances.

Formula: C₂H₃F₃O

Purity: 99+%

Color and Shape: Clear colorless, Liquid

Molecular weight: 100.04

Ref: 02-A10788

2,2,2-Trifluoroethanol, NMR grade, 99.5%

CAS: 75-89-8

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₂H₃F₃O

Purity: 99.5%

Color and Shape: Liquid, Clear, colorless

Molecular weight: 100.04

Ref: 02-L16898

2,2,2-Trifluoroethanol, 99%

CAS: 75-89-8

2,2,2-Trifluoroethanol, 99%

Formula: CF₃CH₂OH

Purity: 99%

Color and Shape: colorless liq.

Molecular weight: 100.04

Ref: 08-09-7310

2,2,2-Trifluoroethan-1-ol

CAS: 75-89-8

2,2,2-Trifluoroethan-1-ol

Formula: C₂H₃F₃O

Purity: 99%

Color and Shape: clear. colourless liquid

Molecular weight: 100.03982g/mol

Ref: 54-PC7310

2,2,2-Trifluoroethanol

Controlled Product

CAS: 75-89-8

Formula: C₂H₃F₃O

Color and Shape: Neat

Molecular weight: 100.04

Ref: 04-C17844600

2,2,2-Trifluoroethanol

CAS: 75-89-8

Formula: C₂H₃F₃O

Purity: 99.0%

Color and Shape: Liquid, Clear Liquid

Molecular weight: 100.04

Ref: 10-F001273

2,2,2-Trifluoroethanol, GlenPure™, analytical grade

CAS: 75-89-8

Formula: C₂H₃F₃O

Purity: ≥ 99.9%

Color and Shape: Clear, colourless liquid

Molecular weight: 100.04

Ref: 7W-GS2953

2,2,2-Trifluoroethanol

CAS: 75-89-8

2,2,2-Trifluoroethanol is a trifluoroacetic acid analogue that has been shown to be an effective antimicrobial agent. It binds to the active site of the enzyme enoyl reductase, inhibiting the synthesis of fatty acids and disrupting cell membrane function. 2,2,2-Trifluoroethanol has also been shown to have anti-inflammatory effects. The drug binds to human serum albumin and inhibits hydrogen peroxide release from neutrophils. This complexation with albumin prevents the release of hydroxyl radicals that are generated in response to oxidative stress. Intramolecular hydrogen bonding between 2,2,2-trifluoroethanol molecules may also contribute to its activity as a natural drug.

Formula: C₂H₃F₃O

Purity: Min. 95%

Color and Shape: Clear Liquid

Molecular weight: 100.04 g/mol

Ref: 3D-FT00267

2,2,2-Trifluoroethanol

Controlled Product

CAS: 75-89-8

Applications 2,2,2-Trifluoroethanol is used in the synthesis of competitive inhibitors for phospholipase A2. Used in the preparation of a key Efavirenz (E425000) intermediate, a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Jain, M. et al.: Biochem., 30, 10256 (1991); Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995), Tan, L. et al.: Angew. Chem. Int. Ed., 38, 711 (1999);

Formula: C₂H₃F₃O

Color and Shape: Neat

Molecular weight: 100.04

Ref: TR-T790175

2,2,2-Trifluoroethanol pure, 99%

CAS: 75-89-8

Formula: C₂H₃F₃O

Purity: min. 99%

Color and Shape: Clear, Colourless, Liquid

Molecular weight: 100.04

Ref: SR-80058