CAS 753498-25-8

Indacaterol maleate

Description:

Indacaterol maleate is a long-acting beta-2 adrenergic agonist primarily used in the management of chronic obstructive pulmonary disease (COPD) and asthma. It is characterized by its ability to relax bronchial smooth muscle, leading to bronchodilation and improved airflow. The substance is a white to off-white powder that is soluble in water and exhibits a pKa value indicative of its ionization properties. Indacaterol maleate has a relatively long half-life, allowing for once-daily dosing, which enhances patient compliance. Its mechanism of action involves selective stimulation of beta-2 adrenergic receptors, resulting in reduced airway resistance. The maleate salt form is utilized to improve the stability and solubility of the active compound. As with other beta-agonists, potential side effects may include cardiovascular effects, tremors, and hypokalemia, necessitating careful monitoring in patients with pre-existing conditions. Overall, indacaterol maleate represents a significant advancement in the pharmacological treatment of obstructive airway diseases.

Formula: C₂₈H₃₂N₂O₇

SMILES: [C@@H](CNC1CC=2C(C1)=CC(CC)=C(CC)C2)(O)C3=C4C(=C(O)C=C3)NC(=O)C=C4.C(=C\C(O)=O)\C(O)=O

Synonyms:

• 2(1H)-Quinolinone, 5-[(1R)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxy-, (2Z)-2-butenedioate (1:1)
• 2(1H)-Quinolinone, 5-[(1R)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxy-, (2Z)-2-butenedioate (1:1) (salt)
• Arcapta
• Hirobriz Breezhaler
• Indacaterol maleate
• Onbrez
• Onbrez Breezhaler
• Oslif Breezhaler
• Qab 149Afa
• [(2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxooxolan-2-yl]methyl benzoate
• Indacaterol maleate salt
• 5-[(1R)-2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)aMino]-1-hydroxyethyl]-8-hydroxy-2(1H)-quinolinone Maleic Acid
• Indacaterol Maleic Acid Salt
• 5-[(1R)-2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxy-2(1H)-quinolinone (2Z)-2-butenedioate
• Indacaterol maleate, 98%, an ultra-long-acting β-adrenoceptor agonist
• QAB 149 Maleic Acid
• (R)-5-(2-((5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino)-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one maleate
• ndacaterol Maleate
• Indacaterol Maleate(API)
• IndacaterolMaleate&gt
• Indacaterol Maleate USP/EP/BP

Indacaterol maleate

CAS: 753498-25-8

Formula: C₂₈H₃₂N₂O₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 508.5629

Ref: IN-DA00G3OP

Indacaterol maleate

CAS: 753498-25-8

Indacaterol maleate (QAB149) is an ultra-long-acting β-adrenoceptor agonist.

Formula: C₂₈H₃₂N₂O₇

Purity: 99.03% - 99.67%

Color and Shape: Solid

Molecular weight: 508.56

Ref: TM-T1239

Indacaterol maleate

CAS: 753498-25-8

Formula: C₂₈H₃₂N₂O₇

Molecular weight: 508.56

Ref: 7W-GP0021

Indacaterol Maleate

CAS: 753498-25-8

Formula: C₂₄H₂₈N₂O₃·C₄H₄O₄

Color and Shape: White To Off-White Solid

Molecular weight: 392.50 116.07

Ref: 4Z-I-065001

Indacaterol Maleate

CAS: 753498-25-8

Color and Shape: Neat

Ref: 86-MM3994.00

Indacaterol Maleic Acid Salt

Controlled Product

CAS: 753498-25-8

Applications A long-acting β2 adrenoreceptor agonist and bronchodilator, for the treatment of asthma and chronic obstructive pulmonary disease.
References Currie, G.P. et al.: Curr. Opin. Invest. Drugs., 7, 457 (2006); Naline, E. et al.: Eur. Resp. J., 29, 575 (2007); Roig, J. et al.: Open Resp. Med. J., 3, 27 (2009);

Formula: C₂₄H₂₈N₂O₃·C₄H₄O₄

Color and Shape: White To Beige

Molecular weight: 508.56

Ref: TR-I499750

Indacaterol maleate

Controlled Product

CAS: 753498-25-8

Long-acting β2-agonist; bronchodilator

Formula: C₂₄H₂₈N₂O₃·C₄H₄O₄

Purity: Min. 95%

Color and Shape: White Off-White Powder

Molecular weight: 508.56 g/mol

Ref: 3D-FI30417