CAS 755037-03-7
:Regorafenib
Description:
Regorafenib is a small molecule drug primarily used in oncology for the treatment of various cancers, including colorectal cancer and gastrointestinal stromal tumors. It functions as a multi-kinase inhibitor, targeting several receptor tyrosine kinases involved in tumor growth and angiogenesis, such as VEGFR, PDGFR, and RAF kinases. Regorafenib is characterized by its complex chemical structure, which includes a pyridine ring and a 4-(methylsulfonyl)phenyl group, contributing to its pharmacological activity. The substance is typically administered orally and is known for its moderate solubility in aqueous solutions. Its mechanism of action involves the inhibition of tumor cell proliferation and the disruption of the tumor microenvironment, thereby impeding cancer progression. Regorafenib is associated with a range of side effects, including fatigue, hypertension, and gastrointestinal disturbances, necessitating careful monitoring during treatment. As a targeted therapy, it represents a significant advancement in personalized cancer treatment, providing options for patients with refractory disease.
Formula:C21H15ClF4N4O3
InChI:InChI=1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32)
InChI key:InChIKey=FNHKPVJBJVTLMP-UHFFFAOYSA-N
SMILES:O(C=1C=C(C(NC)=O)N=CC1)C2=CC(F)=C(NC(NC3=CC(C(F)(F)F)=C(Cl)C=C3)=O)C=C2
Synonyms:- 2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-
- 4-[4-[N′-(4-Chloro-3-trifluoromethylphenyl)ureido]-3-fluorophenoxy]pyridine-2-carboxylic acid methylamide
- 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide
- Bay 73-4506
- Regorafenib
- Stivarga
- 4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
- 4-(4-(3-(4-chloro-3-(trifluoroMethyl)phenyl)ureido)-3-fluorophenoxy)-N-MethylpicolinaMide
- Regafenib
- Regorafenib (BAY 73-4506)
- 4-[4-({[4-chioro-3-(trifluoroMethyl)phenyl]carbaMoyl}aMino)-3-fluorophenoxy]-pyridine-2-carboxylic acid MethylaMide
- BAY 73-4506(Regorafenib)
- Reggae sorafenib
- 4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide Regorafenib BAY 73-4506
- fluorophenoxy]pyridine-2-carboxylic Acid MethylaMide
- Stivarga(regorafenib)
- 4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide
- Fluoro-Sorafenib
- 4-[4-[N'-(4-Chloro-3-trifluoroMethylphenyl)ureido]-3-
- 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea
- Regorafenib C3X-1410
- See more synonyms
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Regorafenib
CAS:Formula:C21H15ClF4N4O3Purity:>98.0%(HPLC)Color and Shape:White to Light yellow to Light orange powder to crystalMolecular weight:482.82Regorafenib
CAS:Formula:C21H15ClF4N4O3Purity:≥ 98.0% (dried basis)Color and Shape:White to off-white powderMolecular weight:482.82Regorafenib
CAS:Formula:C21H15ClF4N4O3Color and Shape:White To Off-White SolidMolecular weight:482.82Regorafenib (Standard)
CAS:Regorafenib (Standard) is a reference standard for research and analysis in studies involving Regorafenib. Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orally active. Regorafenib has antitumor and anti-angiogenic activity.Formula:C21H15ClF4N4O3Molecular weight:482.82Regorafenib
CAS:Controlled ProductApplications It inhibits PDGFR tyrosine kinase with IC50=83nM. It is useful for the treatment of inflammation and as an anti-proliferative agent. Dual action VEGFR & Raf inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Leuner, C., et al.: Eur. J. Pharm. Biopharm., 50, 47 (2000),Formula:C21H15ClF4N4O3Color and Shape:NeatMolecular weight:482.82Regorafenib N-Beta-D-Glucuronide Sodium Salt
CAS:Controlled ProductApplications Regorafenib N-β-D-Glucuronide Sodium Salt, is a derivative of Regorafenib (R143000); a compound that inhibits PDGFR tyrosine kinase with IC50=83nM. Also useful for the treatment of inflammation and as an anti-proliferative agent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Leuner, C., et al.: Eur. J. Pharm. Biopharm., 50, 47 (2000)Formula:C27H22ClF4N4O9·NaColor and Shape:NeatMolecular weight:680.92Regorafenib
CAS:Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orallyFormula:C21H15ClF4N4O3Purity:98% - 99.95%Color and Shape:SolidMolecular weight:482.815Regorafenib
CAS:4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamideFormula:C21H15ClF4N4O3Purity:98%Molecular weight:482.824-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide
CAS:Formula:C21H15ClF4N4O3Purity:98%Color and Shape:SolidMolecular weight:482.82Regorafenib (1-(4-Chloro-3-(trifluoromethyl)phenyl)urea)trimer
CAS:Controlled ProductFormula:C49H31Cl3F10N8O7Color and Shape:NeatMolecular weight:1140.1632-Pyridinecarboxamide,4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-
CAS:Formula:C21H15ClF4N4O3Purity:98%Color and Shape:SolidMolecular weight:482.8154
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