CAS 755037-03-7: Regorafenib

Description:Regorafenib is a small molecule drug primarily used in oncology for the treatment of various cancers, including colorectal cancer and gastrointestinal stromal tumors. It functions as a multi-kinase inhibitor, targeting several receptor tyrosine kinases involved in tumor growth and angiogenesis, such as VEGFR, PDGFR, and RAF kinases. Regorafenib is characterized by its complex chemical structure, which includes a pyridine ring and a 4-(methylsulfonyl)phenyl group, contributing to its pharmacological activity. The substance is typically administered orally and is known for its moderate solubility in aqueous solutions. Its mechanism of action involves the inhibition of tumor cell proliferation and the disruption of the tumor microenvironment, thereby impeding cancer progression. Regorafenib is associated with a range of side effects, including fatigue, hypertension, and gastrointestinal disturbances, necessitating careful monitoring during treatment. As a targeted therapy, it represents a significant advancement in personalized cancer treatment, providing options for patients with refractory disease.

Formula:C₂₁H₁₅ClF₄N₄O₃

InChI:InChI=1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32)

InChI key:InChIKey=FNHKPVJBJVTLMP-UHFFFAOYSA-N

SMILES:O=C(NC1=CC=C(Cl)C(=C1)C(F)(F)F)NC2=CC=C(OC=3C=CN=C(C3)C(=O)NC)C=C2F

Synonyms:
2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-
4-[4-[N′-(4-Chloro-3-trifluoromethylphenyl)ureido]-3-fluorophenoxy]pyridine-2-carboxylic acid methylamide
4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide
Bay 73-4506
Regorafenib
Stivarga

Found 13 products.

Product data	Purity	Price range	Estimated delivery
Regorafenib REF: 3B-R0142CAS: 755037-03-7	>98.0%(HPLC)	80.00 €~208.00 €	Fri 02 May 25
2-Pyridinecarboxamide,4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl- REF: IN-DA00ICN3CAS: 755037-03-7	98%	To inquire	Fri 09 May 25
Regorafenib REF: 54-BUP17780CAS: 755037-03-7	≥98%	288.00 €~1,757.00 €	Mon 12 May 25
Regorafenib REF: 7W-GP6787CAS: 755037-03-7	≥ 98.0% (dried basis)	79.00 €~370.00 €	Mon 12 May 25
Regorafenib REF: 4Z-R-078001CAS: 755037-03-7	- - -	To inquire	Mon 12 May 25
Regorafenib REF: 54-PC109086CAS: 755037-03-7	98%	38.00 €~1,635.00 €	Mon 12 May 25
Regorafenib-13C-d3 REF: 4Z-R-078002CAS: 755037-03-7	- - -	To inquire	Mon 12 May 25
Regorafenib REF: TM-T1792CAS: 755037-03-7	98% - 99.95%	35.00 €~309.00 €	Fri 16 May 25
4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide REF: 10-F361865CAS: 755037-03-7	99.0%	To inquire	Mon 19 May 25
Regorafenib N-β-D-Glucuronide Sodium Salt REF: TR-R143320CAS: 755037-03-7	- - -	408.00 €~2,782.00 €	Mon 19 May 25
Regorafenib REF: TR-R143000CAS: 755037-03-7	- - -	170.00 €~436.00 €	Mon 19 May 25
Regorafenib REF: 3D-FR16116CAS: 755037-03-7	Min. 95%	186.00 €~5,195.00 €	Tue 03 Jun 25
Regorafenib (1-(4-Chloro-3-(trifluoromethyl)phenyl)urea)trimer REF: TR-R143350CAS: 755037-03-7	- - -	16,483.00 €	Fri 20 Jun 25