CAS 755037-03-7

Regorafenib

Description:

Regorafenib is a small molecule drug primarily used in oncology for the treatment of various cancers, including colorectal cancer and gastrointestinal stromal tumors. It functions as a multi-kinase inhibitor, targeting several receptor tyrosine kinases involved in tumor growth and angiogenesis, such as VEGFR, PDGFR, and RAF kinases. Regorafenib is characterized by its complex chemical structure, which includes a pyridine ring and a 4-(methylsulfonyl)phenyl group, contributing to its pharmacological activity. The substance is typically administered orally and is known for its moderate solubility in aqueous solutions. Its mechanism of action involves the inhibition of tumor cell proliferation and the disruption of the tumor microenvironment, thereby impeding cancer progression. Regorafenib is associated with a range of side effects, including fatigue, hypertension, and gastrointestinal disturbances, necessitating careful monitoring during treatment. As a targeted therapy, it represents a significant advancement in personalized cancer treatment, providing options for patients with refractory disease.

Formula: C₂₁H₁₅ClF₄N₄O₃

InChI: InChI=1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32)

InChI key: InChIKey=FNHKPVJBJVTLMP-UHFFFAOYSA-N

SMILES: O(C=1C=C(C(NC)=O)N=CC1)C2=CC(F)=C(NC(NC3=CC(C(F)(F)F)=C(Cl)C=C3)=O)C=C2

Synonyms:

• 2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-
• 4-[4-[N′-(4-Chloro-3-trifluoromethylphenyl)ureido]-3-fluorophenoxy]pyridine-2-carboxylic acid methylamide
• 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide
• Bay 73-4506
• Regorafenib
• Stivarga
• 4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
• 4-(4-(3-(4-chloro-3-(trifluoroMethyl)phenyl)ureido)-3-fluorophenoxy)-N-MethylpicolinaMide
• Regafenib
• Regorafenib (BAY 73-4506)
• 4-[4-({[4-chioro-3-(trifluoroMethyl)phenyl]carbaMoyl}aMino)-3-fluorophenoxy]-pyridine-2-carboxylic acid MethylaMide
• BAY 73-4506(Regorafenib)
• Reggae sorafenib
• 4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide Regorafenib BAY 73-4506
• fluorophenoxy]pyridine-2-carboxylic Acid MethylaMide
• Stivarga(regorafenib)
• 4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide
• Fluoro-Sorafenib
• 4-[4-[N'-(4-Chloro-3-trifluoroMethylphenyl)ureido]-3-
• 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea
• Regorafenib C3X-1410

Regorafenib

CAS: 755037-03-7

Formula: C₂₁H₁₅ClF₄N₄O₃

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 482.82

Ref: 3B-R0142

2-Pyridinecarboxamide,4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-

CAS: 755037-03-7

Formula: C₂₁H₁₅ClF₄N₄O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 482.8154

Ref: IN-DA00ICN3

Regorafenib

CAS: 755037-03-7

Regorafenib

Purity: ≥98%

Molecular weight: 482.82g/mol

Ref: 54-BUP17780

Regorafenib

CAS: 755037-03-7

Formula: C₂₁H₁₅ClF₄N₄O₃

Purity: ≥ 98.0% (dried basis)

Color and Shape: White to off-white powder

Molecular weight: 482.82

Ref: 7W-GP6787

Regorafenib

CAS: 755037-03-7

Formula: C₂₁H₁₅ClF₄N₄O₃

Color and Shape: White To Off-White Solid

Molecular weight: 482.82

Ref: 4Z-R-078001

Regorafenib

CAS: 755037-03-7

Regorafenib

Purity: 98%

Molecular weight: 482.82g/mol

Ref: 54-PC109086

Regorafenib-13C-d3

CAS: 755037-03-7

Formula: C₂₀₁₃CH₁₂D₃ClF₄N₄O₃

Color and Shape: Pink Solid

Molecular weight: 486.83

Ref: 4Z-R-078002

Regorafenib

CAS: 755037-03-7

Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orally

Formula: C₂₁H₁₅ClF₄N₄O₃

Purity: 98% - 99.95%

Color and Shape: Solid

Molecular weight: 482.82

Ref: TM-T1792

4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide

CAS: 755037-03-7

Purity: 99.0%

Color and Shape: Solid

Molecular weight: 482.82000732421875

Ref: 10-F361865

Regorafenib N-Beta-D-Glucuronide Sodium Salt

Controlled Product

CAS: 755037-03-7

Applications Regorafenib N-β-D-Glucuronide Sodium Salt, is a derivative of Regorafenib (R143000); a compound that inhibits PDGFR tyrosine kinase with IC50=83nM. Also useful for the treatment of inflammation and as an anti-proliferative agent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Leuner, C., et al.: Eur. J. Pharm. Biopharm., 50, 47 (2000)

Formula: C₂₇H₂₂ClF₄N₄O₉·Na

Color and Shape: Neat

Molecular weight: 680.92

Ref: TR-R143320

Regorafenib

Controlled Product

CAS: 755037-03-7

Applications It inhibits PDGFR tyrosine kinase with IC50=83nM. It is useful for the treatment of inflammation and as an anti-proliferative agent. Dual action VEGFR & Raf inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Leuner, C., et al.: Eur. J. Pharm. Biopharm., 50, 47 (2000),

Formula: C₂₁H₁₅ClF₄N₄O₃

Color and Shape: Off White Powder

Molecular weight: 482.82

Ref: TR-R143000

Regorafenib (1-(4-Chloro-3-(trifluoromethyl)phenyl)urea)trimer

Controlled Product

CAS: 755037-03-7

Formula: C₄₉H₃₁Cl₃F₁₀N₈O₇

Color and Shape: Neat

Molecular weight: 1140.163

Ref: TR-R143350

Regorafenib

CAS: 755037-03-7

Multi-kinase inhibitor; inhibits epoxide hydrolase; antineoplastic

Formula: C₂₁H₁₅ClF₄N₄O₃

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 482.82 g/mol

Ref: 3D-FR16116