CAS 75530-68-6

Nilvadipine

Description:

Nilvadipine is a calcium channel blocker primarily used in the treatment of hypertension and certain types of angina. It belongs to the dihydropyridine class of medications, which work by inhibiting the influx of calcium ions through L-type calcium channels in vascular smooth muscle and cardiac tissue, leading to vasodilation and reduced blood pressure. Nilvadipine is characterized by its lipophilic nature, which allows for good penetration into tissues, including the central nervous system. The compound has a relatively long half-life, enabling once-daily dosing. Its chemical structure includes a dihydropyridine ring, which is essential for its pharmacological activity. Nilvadipine is also noted for its neuroprotective properties, making it a subject of research in conditions like Alzheimer's disease. As with other calcium channel blockers, potential side effects may include headache, flushing, and peripheral edema. Overall, Nilvadipine is recognized for its efficacy in managing cardiovascular conditions while also being explored for its potential benefits in neurodegenerative diseases.

Formula: C₁₉H₁₉N₃O₆

InChI: InChI=1S/C19H19N3O6/c1-10(2)28-19(24)15-11(3)21-14(9-20)17(18(23)27-4)16(15)12-6-5-7-13(8-12)22(25)26/h5-8,10,16,21H,1-4H3

InChI key: InChIKey=FAIIFDPAEUKBEP-UHFFFAOYSA-N

SMILES: C(OC)(=O)C=1C(C(C(OC(C)C)=O)=C(C)NC1C#N)C2=CC(N(=O)=O)=CC=C2

Synonyms:

• 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Methyl 5-(1-Methylethyl) Ester
• 3,5-Pyridinedicarboxylic Acid, 2-Cyano-1,4-Dihydro-6-Methyl-4-(3-Nitrophenyl)-, 3-Methyl 5-(1-Methylethyl) Ester
• 3-Methyl 5-Propan-2-Yl 2-Cyano-6-Methyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate
• 3-O-Methyl 5-O-propan-2-yl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• 5-Isopropyl 3-methyl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• 5-Isopropyl-3-methyl-2-cyano-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
• Cl 287389
• Escor
• Fk 235
• Fr 34235
• Isopropyl 6-Cyano-5-methoxycarbonyl-2-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate
• Nilvadipine (JP15/USAN)
• Nilvadipino
• Nilvadipinum
• Nivadil
• Nivadip
• Nivaldipine
• O5-isopropyl O3-methyl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4,5,6-tetrahydropyridine-3,5-dicarboxylate
• Skf 102362
• dl-Nilvadipine
• Nilvadipine

Nilvadipine

CAS: 75530-68-6

Formula: C₁₉H₁₉N₃O₆

Purity: >95.0%(N)

Color and Shape: Light yellow to Amber to Dark green powder to crystal

Molecular weight: 385.38

Ref: 3B-N0899

Nilvadipine

CAS: 75530-68-6

Nilvadipine (FK235), a calcium channel blocker (CCB), is utilized for treatment of hypertension.

Formula: C₁₉H₁₉N₃O₆

Purity: 99.86% - 99.93%

Color and Shape: Yellow Prisms

Molecular weight: 385.37

Ref: TM-T1422

Nilvadipine

CAS: 75530-68-6

Formula: C₁₉H₁₉N₃O₆

Purity: 95%

Color and Shape: Solid

Molecular weight: 385.3707

Ref: IN-DA005K5O

Nilvadipine

CAS: 75530-68-6

Nilvadipine

Purity: ≥98%

Molecular weight: 385.37g/mol

Ref: 54-BUP13746

Nilvadipine

CAS: 75530-68-6

Nilvadipine

Purity: 95%

Molecular weight: 385.38g/mol

Ref: 54-OR1027503

Nilvadipine-d4

CAS: 75530-68-6

Formula: C₁₉H₁₅D₄N₃O₆

Color and Shape: Yellow Solid

Molecular weight: 389.40

Ref: 4Z-N-089002

Nilvadipine

CAS: 75530-68-6

Formula: C₁₉H₁₉N₃O₆

Color and Shape: Yellow Solid

Molecular weight: 385.38

Ref: 4Z-N-089001

Nilvadipine

CAS: 75530-68-6

Formula: C₁₉H₂₁N₃O₆

Molecular weight: 387.39

Ref: 7W-GP9887

Nilvadipine-d7

CAS: 75530-68-6

Formula: C₁₉H₁₂D₇N₃O₆

Molecular weight: 392.42

Ref: 4Z-N-089004

Nilvadipine RS

CAS: 75530-68-6

Color and Shape: Yellow Solid Crystalline Powder

Ref: 2K-1107000021

Nilvadipine

CAS: 75530-68-6

Formula: C₁₉H₁₉N₃O₆

Purity: 95%(LC-MS);RG

Molecular weight: 385.376

Ref: 10-F463476

Nilvadipine

Controlled Product

CAS: 75530-68-6

Applications Used as an antihypertensive and antianginal.
References Gross, G.J., et al.: Gen. Pharmacol., 14, 677 (1983), Molyvdas, P.A. and Sperelakis, N.: J. Cardiovasc. Pharmacol., 8, 449 (1986), Mizuno, K., et al.: Res. Comm. Chem. Pathol. Pharmacol., 52, 3 (1986)

Formula: C₁₉H₁₉N₃O₆

Color and Shape: Neat

Molecular weight: 385.37

Ref: TR-N475150