CAS 75530-68-6
:Nilvadipine
Description:
Nilvadipine is a calcium channel blocker primarily used in the treatment of hypertension and certain types of angina. It belongs to the dihydropyridine class of medications, which work by inhibiting the influx of calcium ions through L-type calcium channels in vascular smooth muscle and cardiac tissue, leading to vasodilation and reduced blood pressure. Nilvadipine is characterized by its lipophilic nature, which allows for good penetration into tissues, including the central nervous system. The compound has a relatively long half-life, enabling once-daily dosing. Its chemical structure includes a dihydropyridine ring, which is essential for its pharmacological activity. Nilvadipine is also noted for its neuroprotective properties, making it a subject of research in conditions like Alzheimer's disease. As with other calcium channel blockers, potential side effects may include headache, flushing, and peripheral edema. Overall, Nilvadipine is recognized for its efficacy in managing cardiovascular conditions while also being explored for its potential benefits in neurodegenerative diseases.
Formula:C19H19N3O6
InChI:InChI=1S/C19H19N3O6/c1-10(2)28-19(24)15-11(3)21-14(9-20)17(18(23)27-4)16(15)12-6-5-7-13(8-12)22(25)26/h5-8,10,16,21H,1-4H3
InChI key:InChIKey=FAIIFDPAEUKBEP-UHFFFAOYSA-N
SMILES:C(OC)(=O)C=1C(C(C(OC(C)C)=O)=C(C)NC1C#N)C2=CC(N(=O)=O)=CC=C2
Synonyms:- 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Methyl 5-(1-Methylethyl) Ester
- 3,5-Pyridinedicarboxylic Acid, 2-Cyano-1,4-Dihydro-6-Methyl-4-(3-Nitrophenyl)-, 3-Methyl 5-(1-Methylethyl) Ester
- 3-Methyl 5-Propan-2-Yl 2-Cyano-6-Methyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate
- 3-O-Methyl 5-O-propan-2-yl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- 5-Isopropyl 3-methyl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- 5-Isopropyl-3-methyl-2-cyano-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
- Cl 287389
- Escor
- Fk 235
- Fr 34235
- Isopropyl 6-Cyano-5-methoxycarbonyl-2-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate
- Nilvadipine (JP15/USAN)
- Nilvadipino
- Nilvadipinum
- Nivadil
- Nivadip
- Nivaldipine
- O5-isopropyl O3-methyl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4,5,6-tetrahydropyridine-3,5-dicarboxylate
- Skf 102362
- dl-Nilvadipine
- Nilvadipine
- See more synonyms
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 13 products.
Nilvadipine
CAS:Formula:C19H19N3O6Purity:>95.0%(N)Color and Shape:Light yellow to Amber to Dark green powder to crystalMolecular weight:385.38Nilvadipine
CAS:Nilvadipine (FK235), a calcium channel blocker (CCB), is utilized for treatment of hypertension.Formula:C19H19N3O6Purity:99.86% - 99.93%Color and Shape:SolidMolecular weight:385.37Nilvadipine
CAS:Controlled ProductApplications Used as an antihypertensive and antianginal.
References Gross, G.J., et al.: Gen. Pharmacol., 14, 677 (1983), Molyvdas, P.A. and Sperelakis, N.: J. Cardiovasc. Pharmacol., 8, 449 (1986), Mizuno, K., et al.: Res. Comm. Chem. Pathol. Pharmacol., 52, 3 (1986)Formula:C19H19N3O6Color and Shape:NeatMolecular weight:385.37
