CAS 75695-93-1

Isradipine

Description:

Isradipine is a dihydropyridine calcium channel blocker primarily used in the treatment of hypertension and angina pectoris. It functions by selectively inhibiting L-type calcium channels, leading to vasodilation and reduced peripheral vascular resistance. Isradipine is characterized by its ability to lower blood pressure without significantly affecting heart rate. The compound is typically administered orally and has a relatively long half-life, allowing for once or twice daily dosing. Its chemical structure includes a dihydropyridine ring, which is essential for its pharmacological activity. Isradipine is known for its favorable side effect profile compared to other antihypertensive agents, although it may still cause peripheral edema, dizziness, or flushing in some patients. The substance is metabolized in the liver, primarily through cytochrome P450 enzymes, and is excreted mainly in the urine. Overall, Isradipine represents an important therapeutic option in cardiovascular medicine, particularly for patients requiring effective blood pressure management.

Formula: C₁₉H₂₁N₃O₅

InChI: InChI=1/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3

InChI key: InChIKey=HMJIYCCIJYRONP-UHFFFAOYSA-N

SMILES: C(OC(C)C)(=O)C=1C(C(C(OC)=O)=C(C)NC1C)C=2C=3C(C=CC2)=NON3

Synonyms:

• 2,1,3-Benzoxadiazole, 3,5-pyridinedicarboxylic acid deriv.
• 3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3-methyl 5-(1-methylethyl) ester
• 3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, methyl 1-methylethyl ester
• 3,5-Pyridinedicarboxylic acid, 4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-, methyl 1-methylethyl ester
• 3-O-Methyl 5-O-propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• Clivoten
• DynaCirc
• DynaCirc CR
• DynaCire
• DynaCire CR
• Dynacrine
• Esradin
• Isopropyl methyl (+-)-4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
• Isradipin
• Isradipine [USAN:INN:BAN]
• Isradipino
• Isradipino [Spanish]
• Isradipinum
• Isradipinum [Latin]
• Isrodipine
• Lomir
• Pn 200
• Pn 200-110
• Prescal
• Rebriden
• Unii-Yo1Uk1S598
• (+-)-Isradipine
• 4-(Benzofurazan-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl 5-isopropyl ester
• 4-(4-Benzofurazanyl)-2，6-dimethyl-1，4-dihydro-3，5-pyridinedicarboxylic acid methyl 1-methylethyl ester
• 4-(2,1,3-BENZOXADIAZOL-4-YL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINECARBOXYLIC ACID METHYL 1-METHYLETHYL ESTER
• 4-(4-BENZOFURAZANYL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID METHYL 1-METHYLETHYL ESTER
• Iomir
• Presca
• PN-200-100
• [R,(-)]-4-(Benzofurazan-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester
• 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid Methyl 1-Methylethyl Ester

Isradipine

CAS: 75695-93-1

Formula: C₁₉H₂₁N₃O₅

Purity: >98.0%(HPLC)

Color and Shape: Light orange to Yellow to Green powder to crystal

Molecular weight: 371.39

Ref: 3B-I0876

Isradipine, 98+%

CAS: 75695-93-1

L-type calcium channel blocker

Formula: C₁₉H₂₁N₃O₅

Purity: 98+%

Color and Shape: Powder or crystals or crystalline powder

Molecular weight: 371.39

Ref: 02-J63920

Isradipine

CAS: 75695-93-1

Color and Shape: Neat

Ref: 61-FOR0466.00

ISRADIPINE CRS

CAS: 75695-93-1

ISRADIPINE CRS

Formula: C₁₉H₂₁N₃O₅

Color and Shape: Crystalline Powder. Yellow. Powder.

Molecular weight: 371.3871

Ref: 41-Y0000366

Isradipine

CAS: 75695-93-1

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₁₉H₂₁N₃O₅

Color and Shape: Powder

Molecular weight: 371.39

Ref: 45-1354207

Isradipine

CAS: 75695-93-1

Formula: C₁₉H₂₁N₃O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 371.3871

Ref: IN-DA005AHX

Isradipine

CAS: 75695-93-1

Isradipine

Purity: ≥98%

Molecular weight: 371.39g/mol

Ref: 54-BUP13557

Isradipine

CAS: 75695-93-1

Formula: C₁₉H₂₁N₃O₅

Molecular weight: 371.39

Ref: 7W-GP2233

Isradipine

CAS: 75695-93-1

Isradipine

Purity: 98%

Molecular weight: 371.39g/mol

Ref: 54-OR1027875

Isradipine d3

CAS: 75695-93-1

Formula: C₁₉H₁₈N₃O₅D₃

Molecular weight: 374.41

Ref: 4Z-I-084

Isradipine

CAS: 75695-93-1

Formula: C₁₉H₂₁N₃O₅

Molecular weight: 371.40

Ref: 4Z-I-082

Isradipine

CAS: 75695-93-1

Formula: C₁₉H₂₁N₃O₅

Color and Shape: Neat

Molecular weight: 371.39

Ref: 86-MM0466.00

Isradipine-d7

CAS: 75695-93-1

Formula: C₁₉H₁₄N₃O₅D₇

Molecular weight: 378.44

Ref: 4Z-I-081

Isradipine-d6

CAS: 75695-93-1

Formula: C₁₉H₁₅N₃O₅D₆

Molecular weight: 377.43

Ref: 4Z-I-083

Isradipine

CAS: 75695-93-1

Isradipine (PN 200-110), a dihydropyridine, is an antihypertensive calcium channel blocker that dilates arteries and reduces resistance.

Formula: C₁₉H₂₁N₃O₅

Purity: 99.84% - 99.95%

Color and Shape: Yellow Solid

Molecular weight: 371.39

Ref: TM-T0957

Isradipine

Controlled Product

CAS: 75695-93-1

Applications Isradipine is a dihydropyridine calcium channel blocker. Antihypertensive and antianginal.
References Nelson, E.B., et al.: Clin. Pharmacol. Ther., 40, 694 (1986); Hof, R.P., et al.: J. Cardiovasc. Pharmacol., 8, 221 (1986);

Formula: C₁₉H₂₁N₃O₅

Color and Shape: Neat

Molecular weight: 371.39

Ref: TR-I925000

Isradipine

CAS: 75695-93-1

L-type calcium channel blocker

Formula: C₁₉H₂₁N₃O₅

Purity: Min. 95%

Color and Shape: Yellow Powder

Molecular weight: 371.39 g/mol

Ref: 3D-FI24738

3-methyl 5-propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-3,4-dihydropyridine-3,5-dicarboxylate

CAS: 75695-93-1

Purity: 98%

Molecular weight: 371.3930054

Ref: 10-F801907

Isradipine

CAS: 75695-93-1

Formula: C₁₉H₂₁N₃O₅

Purity: 98.0%

Color and Shape: Solid

Molecular weight: 371.393

Ref: 10-F047201

Isradipine

CAS: 75695-93-1

Isradipine

Formula: C₁₉H₂₁N₃O₅

Purity: 99.6%

Color and Shape: Off-White

Molecular weight: 371.14812

Ref: 47-621