CAS 75706-12-6
:Leflunomide
Description:
Leflunomide is an immunomodulatory drug primarily used in the treatment of rheumatoid arthritis and psoriatic arthritis. It functions as a prodrug, which means it is metabolized in the body to its active form, A77 1726, that inhibits the enzyme dihydroorotate dehydrogenase. This inhibition disrupts the de novo synthesis of pyrimidines, leading to a reduction in lymphocyte proliferation and modulation of immune responses. Leflunomide is characterized by its relatively long half-life, allowing for once-daily dosing. It is typically administered orally and is known for its potential side effects, which can include liver toxicity, gastrointestinal disturbances, and effects on blood cell counts. The drug is contraindicated in pregnancy due to its teratogenic effects. Additionally, leflunomide is often used in combination with other disease-modifying antirheumatic drugs (DMARDs) to enhance therapeutic efficacy. Its chemical structure includes a pyrimidine derivative, contributing to its mechanism of action and pharmacological properties.
Formula:C12H9F3N2O2
InChI:InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18)
InChI key:InChIKey=VHOGYURTWQBHIL-UHFFFAOYSA-N
SMILES:C(NC1=CC=C(C(F)(F)F)C=C1)(=O)C2=C(C)ON=C2
Synonyms:- 4-Isoxazolecarboxamide, 5-methyl-N-[4-(trifluoromethyl)phenyl]-
- 5-Methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide
- 5-Methylisoxazole-4-Carboxylic Acid (4-Trifluoromethyl)Anilide
- 5-methyl-N-[4-(trifluoromethyl) phenyl]-isoxazole-4-carboxamide
- 5-methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazole carboxamide
- Alpha,Alpha,Alpha-Trifluoro-5-Methyl-4-Isoxazolecarboxy-P-Toluidide
- Arava
- Avara
- Cleft
- Hwa 486
- Hwa486
- Leflunomida
- Leflunomidum
- Lefumide
- N-(4-trifluoromethylphenyl)-5-methylisoxazol-4-carboxamide
- Repso
- Rs-34821
- SU 101 (pharmaceutical)
- Su 101
- alfa-alfa-alfa-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidine
- See more synonyms
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Found 18 products.
Leflunomide
CAS:Formula:C12H9F3N2O2Purity:>98.0%(HPLC)(N)Color and Shape:White to Almost white powder to crystalMolecular weight:270.21Leflunomide
CAS:<p>An immunosuppressive agent. Inhibits T and B cell proliferation. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU referenc</p>Formula:C12H9F3N2O2Molecular weight:270.21LEFLUNOMIDE FOR PEAK IDENTIFICATION CRS
CAS:<p>LEFLUNOMIDE FOR PEAK IDENTIFICATION CRS</p>Formula:C12H9F3N2O2Color and Shape:White. Powder.Molecular weight:270.2073LEFLUNOMIDE CRS
CAS:<p>LEFLUNOMIDE CRS</p>Formula:C12H9F3N2O2Color and Shape:White. Powder.Molecular weight:270.2073Leflunomide
CAS:LeflunomideFormula:C12H9F3N2O2Purity:99.9%Color and Shape:Off-WhiteMolecular weight:270.06161Leflunomide
CAS:<p>Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi</p>Formula:C12H9F3N2O2Color and Shape:White PowderMolecular weight:270.06161Leflunomide
CAS:<p>Leflunomide (HWA486) is an immunomodulatory agent used in the therapy of rheumatoid arthritis and psoriatic arthritis.</p>Formula:C12H9F3N2O2Purity:99.52% - 99.96%Color and Shape:Off White Crystalline SolidMolecular weight:270.21Leflunomide
CAS:Formula:C12H9F3N2O2Purity:≥ 98.0%Color and Shape:White to off-white powderMolecular weight:270.21Leflunomide
CAS:Controlled Product<p>Applications An immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases. Therapeutically as a antirheumatic (Merck Index).This compound is suitable for dihydroorotate dehydrogenase (DHODH) related research.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Vrenken, T., et al.: J. Hepatol., 49, 799 (2008), Mazzucco, G., et al.: Clin. Nephrol., 70, 163 (2008), Davies, M., et al.: J. Med. Chem., 52, 2683 (2009),<br></p>Formula:C12H9F3N2O2Color and Shape:NeatMolecular weight:270.21Leflunomide - Bio-X ™
CAS:Controlled Product<p>Leflunomide is a pyrimidine synthesis inhibitor drug that is used to treat rheumatoid arthritis. Although its mechanism of action is not fully determined, this drug has shown to interfere with cell cycle progression by inhibiting dihydroorotate dehydrogenase and has shown antiproliferative activity. As a result of this, it interferes with the expansion of activated autoimmune lymphocytes. Additionally, Leflunomide is a tyrosine kinase inhibitor.</p>Formula:C12H9F3N2O2Purity:Min. 95%Color and Shape:PowderMolecular weight:270.21 g/molLeflunomide
CAS:Controlled Product<p>Src kinase inhibitor; dihydroorotate dehydrogenase inhibitor; aryl hydrocarbon receptor agonist</p>Formula:C12H9F3N2O2Purity:Min. 95%Color and Shape:White PowderMolecular weight:270.21 g/mol5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
CAS:Formula:C12H9F3N2O2Purity:97.0%Color and Shape:No data available.Molecular weight:270.211
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