CAS 75706-12-6: Leflunomide

Description:Leflunomide is an immunomodulatory drug primarily used in the treatment of rheumatoid arthritis and psoriatic arthritis. It functions as a prodrug, which means it is metabolized in the body to its active form, A77 1726, that inhibits the enzyme dihydroorotate dehydrogenase. This inhibition disrupts the de novo synthesis of pyrimidines, leading to a reduction in lymphocyte proliferation and modulation of immune responses. Leflunomide is characterized by its relatively long half-life, allowing for once-daily dosing. It is typically administered orally and is known for its potential side effects, which can include liver toxicity, gastrointestinal disturbances, and effects on blood cell counts. The drug is contraindicated in pregnancy due to its teratogenic effects. Additionally, leflunomide is often used in combination with other disease-modifying antirheumatic drugs (DMARDs) to enhance therapeutic efficacy. Its chemical structure includes a pyrimidine derivative, contributing to its mechanism of action and pharmacological properties.

Formula:C₁₂H₉F₃N₂O₂

InChI:InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18)

InChI key:InChIKey=VHOGYURTWQBHIL-UHFFFAOYSA-N

SMILES:O=C(NC1=CC=C(C=C1)C(F)(F)F)C=2C=NOC2C

Synonyms:
4-Isoxazolecarboxamide, 5-methyl-N-[4-(trifluoromethyl)phenyl]-
5-Methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide
5-Methylisoxazole-4-Carboxylic Acid (4-Trifluoromethyl)Anilide
5-methyl-N-[4-(trifluoromethyl) phenyl]-isoxazole-4-carboxamide
5-methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazole carboxamide
Alpha,Alpha,Alpha-Trifluoro-5-Methyl-4-Isoxazolecarboxy-P-Toluidide
Arava
Avara
Cleft
Hwa 486
See more synonyms
Hwa486
Leflunomida
Leflunomidum
Lefumide
N-(4-trifluoromethylphenyl)-5-methylisoxazol-4-carboxamide
Repso
Rs-34821
SU 101 (pharmaceutical)
Su 101
alfa-alfa-alfa-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidine
Leflunomide

Found 18 products.

Product data	Purity	Price range	Estimated delivery
Leflunomide REF: 02-J65917CAS: 75706-12-6	- - -	To inquire	Thu 26 Jun 25
Leflunomide for peak identification CRS REF: 41-Y0000674CAS: 75706-12-6	- - -	115.00 €	Mon 30 Jun 25
Leflunomide CRS REF: 41-Y0000654CAS: 75706-12-6	- - -	115.00 €	Mon 30 Jun 25
Leflunomide REF: 47-1233CAS: 75706-12-6	99.9%	242.00 €	Mon 30 Jun 25
Leflunomide REF: 45-1356960CAS: 75706-12-6	- - -	576.00 €	Tue 01 Jul 25
Leflunomide REF: TM-T1159CAS: 75706-12-6	99.52% - 99.96%	47.00 €~159.00 €	Wed 02 Jul 25
Leflunomide REF: 54-BUP15817CAS: 75706-12-6	≥98%	63.00 €~273.00 €	Thu 03 Jul 25
Leflunomide REF: 4Z-L-041CAS: 75706-12-6	- - -	To inquire	Thu 03 Jul 25
Leflunomide REF: 54-PC109034CAS: 75706-12-6	99%	32.00 €~1,227.00 €	Thu 03 Jul 25
Leflunomide REF: 86-MM0859.00CAS: 75706-12-6	- - -	305.00 €	Mon 07 Jul 25
Leflunomide REF: 3B-L0250CAS: 75706-12-6	>98.0%(HPLC)(N)	66.00 €~209.00 €	Mon 07 Jul 25
Leflunomide REF: 04-C14606000CAS: 75706-12-6	- - -	120.00 €	Mon 07 Jul 25
Leflunomide REF: 7W-GP6125CAS: 75706-12-6	≥ 98.0%	99.00 €	Wed 09 Jul 25
Teriflunomide Impurity 12 REF: ST-EA-CP-T19003CAS: 75706-12-6	- - -	To inquire	Mon 14 Jul 25
5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide REF: 10-F358076CAS: 75706-12-6	97.0%	To inquire	Mon 14 Jul 25
Leflunomide REF: TR-L322750CAS: 75706-12-6	- - -	94.00 €~122.00 €	Mon 14 Jul 25
Leflunomide - Bio-X ™ REF: 3D-BM164612CAS: 75706-12-6	Min. 95%	140.00 €	Tue 15 Jul 25
Leflunomide REF: 3D-FL16204CAS: 75706-12-6	Min. 95%	190.00 €~796.00 €	Tue 15 Jul 25