CAS 75747-14-7

Tanespimycin

Description:

Tanespimycin, also known as 17-AAG (17-Allylamino-17-demethoxygeldanamycin), is a synthetic derivative of geldanamycin, a natural product with notable antitumor properties. It primarily functions as a heat shock protein 90 (Hsp90) inhibitor, disrupting the chaperone activity of Hsp90, which is crucial for the stability and function of various oncogenic proteins. This mechanism leads to the degradation of client proteins involved in cancer cell proliferation and survival. Tanespimycin exhibits a broad spectrum of activity against various cancer types, including breast, prostate, and lung cancers. Its solubility profile is moderate, and it is typically administered intravenously due to its pharmacokinetic properties. The compound has undergone clinical trials to evaluate its efficacy and safety in cancer treatment, although its use has been limited by issues such as toxicity and the development of resistance. Overall, Tanespimycin represents a significant area of research in targeted cancer therapies, particularly in the context of Hsp90 inhibition.

Formula: C₃₁H₄₃N₃O₈

InChI: InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-11,15-17,19,24-25,27,29,33,36H,1,12-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9+,18-10-,20-15+/t17-,19+,24+,25+,27-,29+/m1/s1

InChI key: InChIKey=AYUNIORJHRXIBJ-TXHRRWQRSA-N

SMILES: N(CC=C)C1=C2C(=O)C(=CC1=O)NC(=O)\C(\C)=C\C=C/[C@H](OC)[C@@H](OC(N)=O)\C(\C)=C\[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)C2

Synonyms:

• (4Z,6E,10E)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-en-1-ylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
• (8R,9R,12R,13S,14R,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-en-1-ylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
• (8S,9S,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-en-1-ylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
• 17-(Allylamino)-17-demethoxygeldanamycin
• 17-(Allylamino)-17-desmethylgeldanamycin
• 17-(Allylamino)geldanamycin
• 17-Allylaminodemethoxygeldanamycin
• 17-Allylaminogeldanamycin
• 17-Demethoxy-17-(2-propenylamino)geldanamycin
• 17-Demethoxy-17-allylaminogeldanamycin
• 17-N-Allylamino-17-demethoxygeldanamycin
• 17Aag
• 2-Azabicyclo[16.3.1]docosane, geldanamycin deriv.
• A 8476
• Bms 722782
• Cp 127374
• Geldanamycin, 17-demethoxy-17-(2-propenylamino)-
• Kos 953
• NSC 330507
• Tanespimycin
• CP127374,NSC-330507
• Gld-36
• 17-AAG (TanespiMycin)
• 17AAG (17-(AllylaMino)-17-deMethoxy-geldanaMycin)
• 17-DEMETHOXY-17-ALLYLAMINO GELDANAMYCIN
• 17-demethoxy-17-(2-propenylamino)-[(3R,5R,6S,7R,8E,10R,11R,12Z,14E)-6-Hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
• 17-AAG (KOS953)
• Telatinib/ 17-AAG
• 17-(ALLYLAMINO)-17-DIMETHOXYGELDANAMYCIN
• 17-AAG, CP 127374
• 17-AAG
• 17-ALLYLAMINO-17-DIMETHOXYGELDANAMYCIN (17-AAG)
• 17-AAG(GeldanaMycin)
• Geldanamycin, 17-allylamino-17-demethoxy-
• Telatinib
• ALLYLAMINOGELDANAMYCIN
• 17-(Allylamino)geldanamycin, 17-AAG, 17-Demethoxy-17-allylamino geldanamycin, CP 127374, Geldanamycin,17-demethoxy-17-(2-propenylamino)-, NSC 330507
• 17-(ALLYLAMINO)-17-DESMETHOXYGELDANAMYCIN
• TELATINIB
• 17-AG
• 17-AGG
• 17-ALLYLAMINO-17-DEMETHOXYGELDANAMYCIN (17-AAG)
• 17-AAG,17AAG
• Geldanamycin, des-o-methyl-17-allylamino-

17-(Allylamino)-17-demethoxygeldanamycin, 99%

CAS: 75747-14-7

17-(Allylamino)-17-demethoxygeldanamycin (17-AAG) inhibits heat shock protein 90 (Hsp90), the expression of heat shock factor-1, and the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2. In addition to its anti-tumor effects, 17-AAG also induces apoptosis. This Thermo Scient

Formula: C₃₁H₄₃N₃O₈

Purity: 99%

Color and Shape: Red to dark red, Powder

Molecular weight: 585.70

Ref: 02-J66960

17-AAG

CAS: 75747-14-7

Formula: C₃₁H₄₃N₃O₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 585.6884

Ref: IN-DA005IF5

17-(Allylamino)-17-demethoxygeldanamycin

CAS: 75747-14-7

17-(Allylamino)-17-demethoxygeldanamycin

Formula: C₃₁H₄₃N₃O₈

Purity: 98% (Typical Value in Batch COA)

Color and Shape: brown solid

Molecular weight: 585.69g/mol

Ref: 54-BIA4307

Tanespimycin

CAS: 75747-14-7

Tanespimycin

Purity: ≥98%

Molecular weight: 585.69g/mol

Ref: 54-BUP11464

17-Allylamino-17-Demethoxygeldanamycin-d5

CAS: 75747-14-7

Formula: C₃₁H₃₈D₅N₃O₈

Molecular weight: 590.73

Ref: 4Z-G-165003

Telatinib

CAS: 75747-14-7

Formula: C₃₁H₄₃N₃O₈

Purity: ≥ 98%

Color and Shape: Red to dark red powder

Molecular weight: 585.69

Ref: 7W-GA5905

17-Allylamino-17-Demethoxygeldanamycin

CAS: 75747-14-7

Formula: C₃₁H₄₃N₃O₈

Molecular weight: 585.70

Ref: 4Z-G-165002

Tanespimycin

CAS: 75747-14-7

Tanespimycin (KOS 953) is an Hsp90 inhibitor (IC50=5 nM) and is selective. Tanespimycin depletes intracellular STK38/NDR1. High-Quality, Low-Cost!

Formula: C₃₁H₄₃N₃O₈

Purity: 98.24% - 99.83%

Color and Shape: Dark Purple Solid

Molecular weight: 585.69

Ref: TM-T6290

17-(Allylamino-d5) Geldanamycin

Controlled Product

CAS: 75747-14-7

Applications Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2.
References Schnur, R.C., et al.: J. Med. Chem., 38, 3806 (1995), Nimmanapalli, R., et al.: Cancer Res., 61, 1799 (2001), Basso, A.D., et al.: Oncogene, 21, 1159 (2002),

Formula: C₃₁D₅H₃₈N₃O₈

Color and Shape: Neat

Molecular weight: 590.719

Ref: TR-A549652

17-AAG

CAS: 75747-14-7

M01354 - 17-AAG

Formula: C₃₁H₄₃N₃O₈

Purity: 98+%

Color and Shape: Solid

Molecular weight: 585.698

Ref: 10-M01354

17-Allylaminogeldanamycin

CAS: 75747-14-7

17-AAG is the first clinically tested hsp90 inhibitor that exhibits antitumor activity. Its antitumor effects are documented in vivo for various animal models, including erbB2-dependent breast cancer, prostate cancer models, and melanoma.

Formula: C₃₁H₄₃N₃O₈

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 585.69 g/mol

Ref: 3D-AA17307

17-(Allylamino) Geldanamycin

CAS: 75747-14-7

Applications Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2.
References Schnur, R.C., et al.: J. Med. Chem., 38, 3806 (1995), Nimmanapalli, R., et al.: Cancer Res., 61, 1799 (2001), Basso, A.D., et al.: Oncogene, 21, 1159 (2002),

Formula: C₃₁H₄₃N₃O₈

Color and Shape: Neat

Molecular weight: 585.69

Ref: TR-A549650