CAS 75747-14-7: Tanespimycin

Description:Tanespimycin, also known as 17-AAG (17-Allylamino-17-demethoxygeldanamycin), is a synthetic derivative of geldanamycin, a natural product with notable antitumor properties. It primarily functions as a heat shock protein 90 (Hsp90) inhibitor, disrupting the chaperone activity of Hsp90, which is crucial for the stability and function of various oncogenic proteins. This mechanism leads to the degradation of client proteins involved in cancer cell proliferation and survival. Tanespimycin exhibits a broad spectrum of activity against various cancer types, including breast, prostate, and lung cancers. Its solubility profile is moderate, and it is typically administered intravenously due to its pharmacokinetic properties. The compound has undergone clinical trials to evaluate its efficacy and safety in cancer treatment, although its use has been limited by issues such as toxicity and the development of resistance. Overall, Tanespimycin represents a significant area of research in targeted cancer therapies, particularly in the context of Hsp90 inhibition.

Formula:C₃₁H₄₃N₃O₈

InChI:InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-11,15-17,19,24-25,27,29,33,36H,1,12-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9+,18-10-,20-15+/t17-,19+,24+,25+,27-,29+/m1/s1

InChI key:InChIKey=AYUNIORJHRXIBJ-TXHRRWQRSA-N

SMILES:O=C(OC1C(=CC(C)C(O)C(OC)CC(C)CC=2C(=O)C(=CC(=O)C2NCC=C)NC(=O)C(=CC=CC1OC)C)C)N

Synonyms:
(4Z,6E,10E)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-en-1-ylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
(8R,9R,12R,13S,14R,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-en-1-ylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
(8S,9S,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-en-1-ylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
17-(Allylamino)-17-demethoxygeldanamycin
17-(Allylamino)-17-desmethylgeldanamycin
17-(Allylamino)geldanamycin
17-Allylaminodemethoxygeldanamycin
17-Allylaminogeldanamycin
17-Demethoxy-17-(2-propenylamino)geldanamycin
17-Demethoxy-17-allylaminogeldanamycin
See more synonyms
17-N-Allylamino-17-demethoxygeldanamycin
17Aag
2-Azabicyclo[16.3.1]docosane, geldanamycin deriv.
A 8476
Bms 722782
Cp 127374
Geldanamycin, 17-demethoxy-17-(2-propenylamino)-
Kos 953
NSC 330507
Tanespimycin

Found 12 products.

Product data	Purity	Price range	Estimated delivery
17-(Allylamino)-17-demethoxygeldanamycin, 99% REF: 02-J66960CAS: 75747-14-7	99%	To inquire	Tue 29 Apr 25
17-AAG REF: IN-DA005IF5CAS: 75747-14-7	98%	To inquire	Mon 05 May 25
17-(Allylamino)-17-demethoxygeldanamycin REF: 54-BIA4307CAS: 75747-14-7	98% (Typical Value in Batch COA)	71.00 €~271.00 €	Tue 06 May 25
Tanespimycin REF: 54-BUP11464CAS: 75747-14-7	≥98%	158.00 €~1,368.00 €	Tue 06 May 25
17-Allylamino-17-Demethoxygeldanamycin-d5 REF: 4Z-G-165003CAS: 75747-14-7	- - -	To inquire	Mon 12 May 25
Telatinib REF: 7W-GA5905CAS: 75747-14-7	≥ 98%	86.00 €~157.00 €	Mon 12 May 25
17-Allylamino-17-Demethoxygeldanamycin REF: 4Z-G-165002CAS: 75747-14-7	- - -	To inquire	Mon 12 May 25
Tanespimycin REF: TM-T6290CAS: 75747-14-7	99.07% - 99.83%	46.00 €~96.00 €	Mon 12 May 25
17-(Allylamino-d5) Geldanamycin REF: TR-A549652CAS: 75747-14-7	- - -	423.00 €~1,547.00 €	Tue 13 May 25
17-AAG REF: 10-M01354CAS: 75747-14-7	98+%	To inquire	Tue 13 May 25
17-Allylaminogeldanamycin REF: 3D-AA17307CAS: 75747-14-7	Min. 95%	143.00 €~1,075.00 €	Wed 14 May 25
17-(Allylamino) Geldanamycin REF: TR-A549650CAS: 75747-14-7	- - -	118.00 €~638.00 €	Fri 13 Jun 25