CAS 759-73-9

N-Ethyl-N-nitrosourea

Description:

N-Ethyl-N-nitrosourea (ENU) is a potent alkylating agent and a member of the nitrosourea family, primarily used in research settings, particularly in the fields of cancer biology and genetics. It is a colorless to pale yellow liquid that is highly soluble in organic solvents but has limited solubility in water. ENU is known for its ability to induce mutations by adding ethyl groups to DNA, which can lead to various genetic alterations. This property makes it valuable for creating animal models of human diseases, especially in studies related to tumorigenesis. However, ENU is also recognized as a carcinogen and poses significant health risks, including potential reproductive toxicity and teratogenic effects. Therefore, it must be handled with extreme caution in controlled laboratory environments, using appropriate safety measures to mitigate exposure. Its chemical structure includes a nitrosourea moiety, which contributes to its reactivity and biological effects. Overall, N-Ethyl-N-nitrosourea is a critical tool in molecular biology, despite its hazardous nature.

Formula: C₃H₇N₃O₂

InChI: InChI=1S/C3H7N3O2/c1-2-6(5-8)3(4)7/h2H2,1H3,(H2,4,7)

InChI key: InChIKey=FUSGACRLAFQQRL-UHFFFAOYSA-N

SMILES: N(C(N)=O)(CC)N=O

Synonyms:

• 1-Ethyl-1-nitrosomocovina
• 1-Ethyl-1-nitrosomocovina [Czech]
• AENH [German]
• ANH
• ANH [German]
• Aenh
• Aethylnitroso-harnstoff
• Aethylnitroso-harnstoff [German]
• Brn 1761174
• Carbamide, N-ethyl-N-nitroso-
• Ccris 302
• ENU
• Ethyl nitrosourea
• Ethylnitrosourea
• Hsdb 5111
• N-Aethyl-N-Nitroso-Harnstoff
• N-Ethyl-N-nitosourea
• N-Ethyl-N-nitroso carbamide
• N-Ethyl-N-nitroso-urea
• N-Ethyl-N-nitrosoharnstoff
• N-Ethyl-N-nitrosourea
• N-Ethyl-N-nitrosouree
• N-Ethylnitrosourea
• N-Nitroso-N-ethylurea
• N-Nitrosoethylurea
• N-etil-N-nitrosourea
• NE-Urea
• NEU
• Nitrosoethylurea
• Nsc 45403
• RCRA waste no. U176
• RCRA waste number U176
• Urea, 1-ethyl-1-nitroso-
• Urea, N-ethyl-N-nitroso-
• 3-04-00-00233 (Beilstein Handbook Reference)

N-Nitroso-N-Ethylurea

CAS: 759-73-9

Formula: C₃H₇N₃O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 117.1066

Ref: IN-DA003T91

N-Nitroso-N-Ethylurea

CAS: 759-73-9

N-Nitroso-N-Ethylurea

Purity: 95%

Molecular weight: 117.11g/mol

Ref: 54-OR1027192

N-Ethyl-N-nitrosourea

CAS: 759-73-9

N-Ethyl-N-nitrosourea (ENU) is a DNA alkylating agent. It induces leukemia by alkylating nucleobases, thereby damaging DNA, which leads to bone marrow suppression and the development of leukemia cells. ENU is teratogenic in vivo, causing tumor formation and foot malformations in pregnant rats. Additionally, it can result in central nervous system (CNS) tumors and genetic disorders.

Formula: C₃H₇N₃O₂

Color and Shape: Solid

Molecular weight: 117.11

Ref: TM-T203564

N-Nitroso-N-ethyl Urea (Contains 40% water, 1.8 % AcOH)

Controlled Product

CAS: 759-73-9

Stability Temperature Sensitive
Applications Precursor of Diazoethane
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References 1. Chemistry--A European Journal, 15(12), 2923-2931, (2009), Journal of the American Chemical Society, 129(19), 6210-6215, (2007).

Formula: C₃H₇N₃O₂

Color and Shape: Neat

Molecular weight: 117.11

Ref: TR-N526100