CAS 76-66-4

Rhynchophylline

Description:

Rhynchophylline is an alkaloid primarily derived from the plant species Uncaria rhynchophylla, commonly known as cat's claw. It is characterized by its complex chemical structure, which includes a tetracyclic framework. Rhynchophylline exhibits a range of pharmacological properties, including neuroprotective, anti-inflammatory, and analgesic effects. It has been studied for its potential therapeutic applications in conditions such as hypertension and neurodegenerative diseases. The compound interacts with various neurotransmitter systems, particularly influencing the central nervous system. Additionally, rhynchophylline has shown promise in modulating calcium channels and may possess antioxidant properties. Its solubility is generally low in water but can vary in organic solvents. As with many alkaloids, the safety profile and potential side effects of rhynchophylline require further investigation, particularly in long-term use or at high doses. Overall, rhynchophylline represents a significant area of interest in natural product chemistry and pharmacology, warranting further research to fully elucidate its mechanisms of action and therapeutic potential.

Formula: C₂₂H₂₈N₂O₄

InChI: InChI=1/C22H28N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h5-8,13-15,19H,4,9-12H2,1-3H3,(H,23,26)/b16-13-/t14-,15-,19?,22?/m0/s1

InChI key: InChIKey=DAXYUDFNWXHGBE-KAXDATADSA-N

SMILES: O=C1[C@@]2([C@]3(N(CC2)C[C@H](CC)[C@@H](\C(\C(OC)=O)=C/OC)C3)[H])C=4C(N1)=CC=CC4

Synonyms:

• Corynoxan-16-carboxylic acid, 16,17-didehydro-17-methoxy-2-oxo-, methyl ester, (7β,16E,20α)-
• Mitrinermin
• Mitrinermine
• NSC 21731
• Rhyncholphylline
• Rhynchophyllin
• Rhyncophylline
• Spiro[3H-indole-3,1′(5′H)-indolizine]-7′-acetic acid, 6′-ethyl-1,2,2′,3′,6′,7′,8′,8′a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, (αE,1′R,6′R,7′S,8′aS)-
• Spiro[3H-indole-3,1′(5′H)-indolizine]-7′-acetic acid, 6′-ethyl-1,2,2′,3′,6′,7′,8′,8′a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, [1′R-[1′α,6′β,7′α(E),8′aβ]]-
• methyl (16Z)-16-(methoxymethylidene)-2-oxocorynoxan-17-oate
• methyl (3xi,16E,20alpha)-16-(methoxymethylidene)-2-oxocorynoxan-17-oate
• methyl (3xi,16Z,20alpha)-16-(methoxymethylidene)-2-oxocorynoxan-17-oate
• methyl (7beta,16E,20alpha)-16-(methoxymethylidene)-2-oxocorynoxan-17-oate
• Rhynchophylline
• UNCARINE D(P)
• (7R,16E,20R)-16,17-Didehydro-17-methoxy-2-oxocorynoxan-16-carboxylic acid methyl ester
• Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid,6'-ethyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-,methyl ester, (αE,1'R,6'R,7'S,8'aS)-
• 16e,20-alpha)-(7-bet

Rhynchophylline

CAS: 76-66-4

Formula: C₂₂H₂₈N₂O₄

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 384.48

Ref: 3B-R0105

Rhynchophylline

CAS: 76-66-4

Rhynchophylline

Purity: ≥98%

Molecular weight: 384.47g/mol

Ref: 54-BUP02284

Rhynchophylline

CAS: 76-66-4

Formula: C₂₂H₂₈N₂O₄

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 384.47

Ref: 7W-GP0939

Rhynchophylline

CAS: 76-66-4

Rhynchophylline

Purity: 98%

Molecular weight: 384.47g/mol

Ref: 54-OR1023242

Rhynchophylline

CAS: 76-66-4

Rhynchophylline, a noncompetitive antagonist of the NMDA receptor, which has anti-inflammatory, anti-hypertension, cardiacprotective and neuroprotective activities. Rhynchophylline can markedly inhibit rabbit platelet aggregation induced by ADP or thrombin possibly by depressing the inflow of Ca2+ and the rise of the cytoplasmic free calcium level in platelet.Rhynchophylline can reduce the systolic blood pressure (SBP) of spontaneously hypertensive rats (SHR) significantly, decrease plasma Ang II, ADMA, and AT1R levels, and promote serum NO and NOS levels, which has the protection of vascular endothelial function.

Formula: C₂₂H₂₈N₂O₄

Purity: 95%~99%

Molecular weight: 384.476

Ref: BP-BP1216

Rhynchophylline

CAS: 76-66-4

Rhynchophylline (Mitrinermine) is an alkaloid isolated from Crocus sativus and is widely used in anti-inflammatory and neuroprotective studies.

Formula: C₂₂H₂₈N₂O₄

Purity: 99.44% - 99.98%

Color and Shape: Red Brown Or White Fine Powder

Molecular weight: 384.47

Ref: TM-T6S0659

Rhynchophylline

CAS: 76-66-4

Formula: C₂₂H₂₈N₂O₄

Molecular weight: 384.48

Ref: 4Z-R-173001

Rhynchophylline

CAS: 76-66-4

Natural alkaloid

Formula: C₂₂H₂₈N₂O₄

Purity: ≥ 90.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 384.48

Ref: 5G-80526

Rhynchophylline

CAS: 76-66-4

Applications Rhynchophylline is a novel erythropoietin-producing hepatocellular A4 (EphA4) inhibitor.
References Fu, A K.Y., et. al.: P. Natl. Acad. Sci. USA., 111, 9959 (2014)

Formula: C₂₂H₂₈N₂O₄

Color and Shape: Neat

Molecular weight: 384.47

Ref: TR-R414180

Rhynchophylline

CAS: 76-66-4

Rhynchophylline is an indole alkaloid, which is naturally sourced from the Uncaria genus, specifically from Uncaria rhynchophylla. This alkaloid exhibits its mode of action primarily through non-competitive inhibition of NMDA receptors and L-type calcium channels. It has been observed to modulate both glutamatergic and serotonergic signaling pathways, which underscores its potential neurological impacts.

Formula: C₂₂H₂₈N₂O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 384.47 g/mol

Ref: 3D-FR42770

Rhynchophylline - Bio-X ™

CAS: 76-66-4

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₂₂H₂₈N₂O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 384.47 g/mol

Ref: 3D-BR300119