CAS 7689-03-4
:Camptothecin
Description:
Camptothecin is a naturally occurring alkaloid derived from the bark of the Chinese tree Camptotheca acuminata. It is classified as a topoisomerase I inhibitor, which means it interferes with the enzyme responsible for DNA replication and transcription, ultimately leading to cell death, particularly in rapidly dividing cancer cells. Camptothecin exhibits a complex structure characterized by a pentacyclic ring system, which is crucial for its biological activity. The compound is known for its potent antitumor properties and has been the basis for the development of several semi-synthetic derivatives, such as irinotecan and topotecan, which are used in cancer therapy. Camptothecin is relatively insoluble in water but soluble in organic solvents, which can pose challenges for its formulation and delivery in clinical settings. Its pharmacokinetics and toxicity profile are important considerations in its therapeutic application, as it can cause side effects such as myelosuppression and gastrointestinal disturbances. Overall, camptothecin remains a significant compound in cancer research and treatment.
Formula:C20H16N2O4
InChI:InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1
InChI key:InChIKey=VSJKWCGYPAHWDS-FQEVSTJZSA-N
SMILES:C(C)[C@]1(O)C2=C(C(=O)N3C(=C2)C=4C(C3)=CC=5C(N4)=CC=CC5)COC1=O
Synonyms:- (+)-Camptothecin
- (4S)-4-Ethyl-4-hydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- (S)-Camptothecin
- 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (4S)-
- 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-
- 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (4S)-
- 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-
- 20(S)-Camptothecin
- 20(S)-Camptothecine
- 4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- 4-Ethyl-4-hydroxy-1H-pyrano-[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- Campathecin
- Campothecin
- Camptothccin
- Camptothecin, Camptotheca acuminata
- Mag-Cpt
- N-cyclohexyl-9-pentofuranosyl-9H-purin-6-amine
- Nsc 94600
- S-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- S-Ckd 602
- d-Camptothecin
- See more synonyms
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Found 17 products.
(S)-(+)-Camptothecin
CAS:Formula:C20H16N2O4Purity:>97.0%(HPLC)Color and Shape:White to Yellow to Green powder to crystalMolecular weight:348.36Topotecan Related Compound C ((S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione)
CAS:Vegetable alkaloids, natural or reproduced by synthesis, their salts and other derivatives, nesoiFormula:C20H16N2O4Color and Shape:PowderMolecular weight:348.11101(19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione
CAS:Formula:C20H16N2O4Purity:98%Color and Shape:SolidMolecular weight:348.3520(S)-(+)-Camptothecin
CAS:(S)-(+)-CamptothecinFormula:C20H16N2O4Purity:98% (Typical Value in Batch COA)Color and Shape:Yellow Solid-PowderMolecular weight:348.35203(4S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
CAS:(4S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dioneFormula:C20H16N2O4Purity:≥95%Color and Shape:Yellow Solid-PowderMolecular weight:348.35203(S)-(+)-Camptothecin
CAS:Formula:C20H16N2O4Purity:≥ 95.0%Color and Shape:Light-yellow to brown crystalline powderMolecular weight:348.35Camptothecin
CAS:Natural alkaloidFormula:C20H16N2O4Purity:≥ 90.0 % (HPLC)Color and Shape:PowderMolecular weight:348.36(S)-(+)-Camptothecin
CAS:Controlled ProductImpurity Topotecan USP Related Compound C
Applications Antitumor alkaloid. Binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Potmesil, M., et al.: Cancer Res., 54, 1431 (1994), Desai, S.D., et al.: J. Biol. Chem., 272, 24159 (1997), Fan, Y., et al.: J. Med. Chem., 41, 2216 (1998), Kaufmann, S.H., et al.: Biochim. Biophys. Acta, 1400, 195 (1998),Formula:C20H16N2O4Color and Shape:NeatMolecular weight:348.35(S)-(+)-Camptothecin
CAS:(S)-(+)-Camptothecin is a natural alkaloid compound, which is an extract from the Camptotheca acuminata tree. This natural source underlines the compound's origin, emphasizing its role in nature’s diverse chemistry. The primary mode of action of (S)-(+)-Camptothecin involves the inhibition of DNA topoisomerase I, an enzyme essential for DNA replication. By stabilizing the transient DNA-enzyme complex, it induces DNA damage, ultimately leading to apoptosis in rapidly dividing cells.Formula:C20H16N2O4Purity:Min. 98 Area-%Color and Shape:Yellow PowderMolecular weight:348.35 g/molCamptothecin
CAS:M01564 - Camptothecin
Formula:C20H16N2O4Purity:98%Color and Shape:Solid, Crystalline PowderMolecular weight:348.358Camptothecin
CAS:Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity.Formula:C20H16N2O4Purity:99.52% - 99.88%Color and Shape:Solid PowderMolecular weight:348.35
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