CAS 77284-32-3

Fmoc-L-Norleucine

Description:

Fmoc-L-Norleucine is a derivative of the amino acid norleucine, which is an analog of leucine. The "Fmoc" (9-fluorenylmethoxycarbonyl) group is a common protective group used in peptide synthesis, allowing for the selective protection of the amino group during the formation of peptide bonds. This compound is characterized by its hydrophobic nature due to the presence of the norleucine side chain, which contributes to its role in influencing the folding and stability of peptides. Fmoc-L-Norleucine is typically utilized in solid-phase peptide synthesis, where the Fmoc group can be easily removed under basic conditions, facilitating the sequential addition of amino acids. The compound is generally stable under standard laboratory conditions but should be stored in a cool, dry place to prevent degradation. Its applications extend to research in biochemistry and molecular biology, particularly in the design of peptides with specific structural and functional properties.

Formula: C₂₁H₂₂NO₄

InChI: InChI=1/C21H23NO4/c1-2-3-12-19(20(23)24)22-21(25)26-13-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,2-3,12-13H2,1H3,(H,22,25)(H,23,24)/p-1/t19-/m1/s1

SMILES: CCCC[C@H](C(=O)[O-])N=C(O)OCC1c2ccccc2c2ccccc12

Synonyms:

• N-alpha-9-Fluorenylmethoxycarbonyl-L-norleucine
• Fmoc-Nle-OH
• N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-norleucine
• (2R)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}hexanoate

Fmoc-Nle-OH

CAS: 77284-32-3

Formula: C₂₁H₂₃NO₄

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 353.42

Ref: 3B-F1324

Fmoc-Nle-OH

CAS: 77284-32-3

Bachem ID: 4004485.

Formula: C₂₁H₂₃NO₄

Purity: 99.90%

Color and Shape: White

Molecular weight: 353.42

Ref: 01-4004485

N-(9-Fluorenylmethoxycarbonyl)-L-norleucine

CAS: 77284-32-3

Formula: C₂₁H₂₃NO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 353.4116

Ref: IN-DA0036MB

Fmoc-Nle-OH

CAS: 77284-32-3

Formula: C₂₁H₂₃NO₄

Molecular weight: 353.42

Ref: 7W-GM0284

(2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)hexanoic acid

CAS: 77284-32-3

(2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)hexanoic acid

Purity: 98%

Molecular weight: 353.41g/mol

Ref: 54-OR480632

Fmoc-L-norleucine

CAS: 77284-32-3

Fmoc-L-norleucine is a non-natural amino acid that can be used to study the interactions of proteins with cellular receptors. It is synthesized from methylandrostenediol and caproic acid, which are then reacted with sodium salt. The resultant product contains a tertiary amine group that interacts with the surface receptor. Fmoc-L-norleucine has shown affinity for endogenous ligands such as nucleobases and phospholipids on cell membranes. In addition, it has been shown to interact with other proteins through its side chain, including erythrocyte band 3 protein. Fmoc-L-norleucine also has a high affinity for binding to divalent metal ions such as calcium and magnesium in aqueous solution, giving it potential applications in the field of analytical chemistry.

Formula: C₂₁H₂₃NO₄

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 353.41 g/mol

Ref: 3D-FF47349

FMOC-NLE-OH

CAS: 77284-32-3

Formula: C₂₁H₂₃NO₄

Purity: 98%

Color and Shape: Solid, Crystalline

Molecular weight: 353.418

Ref: 10-F045402

FMOC-L-Norleucine extrapure, 99%

CAS: 77284-32-3

Formula: C₂₁H₂₃NO₄

Purity: min. 99%

Color and Shape: White, Crystalline powder

Molecular weight: 353.40

Ref: SR-35941

N-Fmoc-L-norleucine, 98%

CAS: 77284-32-3

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₂₁H₂₃NO₄

Purity: 98%

Color and Shape: White, Powder

Molecular weight: 353.42

Ref: 02-B22475