CAS 7772-94-3

2-(Acetylamino)-2-deoxy-β-D-mannopyranose

Description:

2-(Acetylamino)-2-deoxy-β-D-mannopyranose, commonly referred to as N-acetylmannosamine, is an amino sugar that plays a significant role in various biological processes, particularly in glycoprotein and glycolipid synthesis. This compound features an acetylamino group at the C-2 position of the mannopyranose ring, which contributes to its biochemical properties. It is typically a white to off-white crystalline solid that is soluble in water, reflecting its polar nature due to the hydroxyl and amino groups. The presence of the acetylamino group enhances its reactivity and allows it to participate in various metabolic pathways, including those involved in sialic acid biosynthesis. N-acetylmannosamine is also important in cell signaling and recognition processes, making it a subject of interest in research related to cellular interactions and disease mechanisms. Its CAS number, 7772-94-3, is used for identification in chemical databases and regulatory contexts. Overall, this compound is significant in both biochemistry and pharmaceutical applications.

Formula: C₈H₁₅NO₆

InChI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5+,6-,7-,8-/m1/s1

InChI key: InChIKey=OVRNDRQMDRJTHS-OZRXBMAMSA-N

SMILES: N(C(C)=O)[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O

Synonyms:

• 2-(Acetylamino)-2-Deoxyhexopyranose Hydrate
• 2-(Acetylamino)-2-deoxy-β-<span class="text-smallcaps">D</span>-mannopyranose
• 2-(acetylamino)-2-deoxy-alpha-D-gulopyranose
• Mannopyranose, 2-acetamido-2-deoxy-, β-<span class="text-smallcaps">D</span>-
• N-Acetyl-D-mannosamine monohydrate
• β-<span class="text-smallcaps">D</span>-Mannopyranose, 2-(acetylamino)-2-deoxy-
• 2-(Acetylamino)-2-deoxy-β-D-mannopyranose
• β-D-Mannopyranose, 2-(acetylamino)-2-deoxy-
• Mannopyranose, 2-acetamido-2-deoxy-, β-D-

N-Acetylmannosamine

CAS: 7772-94-3

Formula: C₈H₁₅NO₆

Purity: 95%

Color and Shape: Solid

Molecular weight: 221.2078

Ref: IN-DA003SOW

N-Acetyl-D-mannosamine

CAS: 7772-94-3

Formula: C₈H₁₅NO₆·xH₂O

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 221.21 (anhydrous)

Ref: 7W-GK3319

2-(Acetamido)-2-deoxy-β-D-mannopyranose

CAS: 7772-94-3

2-(Acetamido)-2-deoxy-β-D-mannopyranose

Purity: 97% (Monohydrate)

Molecular weight: 221.21g/mol

Ref: 54-OR8153

N-Acetyl-D-mannosamine

CAS: 7772-94-3

N-Acetyl-D-mannosamine

Color and Shape: White To Off White Powder

Molecular weight: 239.22g/mol

Ref: 54-BIA1221

Cyclic N-Acetyl-D-mannosamine

CAS: 7772-94-3

Cyclic N-Acetyl-D-mannosamine is used for sialic acid synthesis and as a precursor for biologically active compounds.

Formula: C₈H₁₅NO₆

Purity: 99.18% - 99.72%

Color and Shape: White Crystal Powder

Molecular weight: 221.21

Ref: TM-T4725

N-Acetyl-D-mannosamine

CAS: 7772-94-3

N-Acetyl D-mannosamine (ManNAc) is an aldohexose (2-acetamido-2-deoxymannose) in which the axial hydroxyl group at position 2 is replaced by a N-acetyl group (Collins, 2006). It has been reported that N-acetyl D-mannosamine supplementation, may provide novel means to break the link between obesity and hypertension (Peng, 2019). N-Acetyl-D-mannosamine and N-acetyl-D-glucosamine are the essential precursors of sialic acid, the specific monomer of polysialic acid, a bacterial pathogenic determinant, for example, Escherichia coli K1 uses both amino sugars as carbon sources. Glycoproteins normally have some level of glycan sialylation, but incomplete sialylation can reduce their therapeutic effect when produced recombinantly. To improve performance, cell lines and culture media can be adjusted. The GNE enzyme controls the efficiency of sialylation in human cell lines, making it crucial for producing effective recombinant glycoprotein drugs. Adding ManNAc and other supplements to culture media improves sialylation, which boosts drug yield, increases stability and half-life, and lowers immune reactions by reducing antibody formation.It has also been reported that ManNAc can be used as a treatment for hereditary inclusion body myopathy, an adult-onset, progressive neuromuscular disorder and also for renal disorders involving proteinuria and hematuria due to podocytopathy and/or segmental splitting of the glomerular basement membrane (Galeano, 2007).

Formula: C₈H₁₅NO₆

Purity: Min. 97.5 Area-%

Molecular weight: 221.21 g/mol

Ref: 3D-Z-1000

N-Acetyl-D-mannosamine - low endotoxin grade

CAS: 7772-94-3

Please enquire for more information about N-Acetyl-D-mannosamine - low endotoxin grade including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₈H₁₅NO₆

Molecular weight: 221.21 g/mol

Ref: 3D-Z-1082

N-Acetyl-D-mannosamine

CAS: 7772-94-3

Purity: 95%

Molecular weight: 221.21

Ref: 10-F493709

N-Acetyl-D-mannosamine

CAS: 7772-94-3

N-Acetyl D-mannosamine (ManNAc) is an aldohexose (2-acetamido-2-deoxymannose) in which the axial hydroxyl group at position 2 is replaced by a N-acetyl group (Collins, 2006). It has been reported that N-acetyl D-mannosamine supplementation, may provide novel means to break the link between obesity and hypertension (Peng, 2019). N-Acetyl-D-mannosamine and N-acetyl-D-glucosamine are the essential precursors of sialic acid, the specific monomer of polysialic acid, a bacterial pathogenic determinant, for example, Escherichia coli K1 uses both amino sugars as carbon sources. It has been reported that ManNAc can be used as a treatment for hereditary inclusion body myopathy, an adult-onset, progressive neuromuscular disorder and also for renal disorders involving proteinuria and hematuria due to podocytopathy and/or segmental splitting of the glomerular basement membrane (Galeano, 2007).

Formula: C₈H₁₅NO₆

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 221.21 g/mol

Ref: 3D-MA05269