CAS 77883-43-3

Doxazosin mesylate

Description:

Doxazosin mesylate is a pharmaceutical compound primarily used as an antihypertensive and an alpha-1 adrenergic antagonist. It is commonly prescribed for the treatment of hypertension and benign prostatic hyperplasia (BPH). The substance is characterized by its ability to selectively block alpha-1 adrenergic receptors, leading to vasodilation and a subsequent decrease in blood pressure. Doxazosin mesylate is typically administered in oral form and is known for its long half-life, allowing for once-daily dosing. The mesylate salt form enhances its solubility and stability, facilitating better absorption in the gastrointestinal tract. In terms of physical properties, doxazosin mesylate is a white to off-white crystalline powder, which is soluble in water and organic solvents. Its chemical structure includes a quinazoline ring, contributing to its pharmacological activity. As with any medication, potential side effects may include dizziness, fatigue, and orthostatic hypotension, necessitating careful monitoring during treatment.

Formula: C₂₃H₂₅N₅O₅·CH₄O₃S

InChI: InChI=1S/C23H25N5O5.CH4O3S/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20;1-5(2,3)4/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26);1H3,(H,2,3,4)

InChI key: InChIKey=VJECBOKJABCYMF-UHFFFAOYSA-N

SMILES: NC=1C2=C(N=C(N1)N3CCN(C(=O)C4OC=5C(OC4)=CC=CC5)CC3)C=C(OC)C(OC)=C2.S(C)(=O)(=O)O

Synonyms:

• 1,4-Benzodioxin, piperazine deriv.
• 1-(4-Amino-6,7-Dimethoxy-2-Quinazolinyl)-4-(1,4-Benzodioxan-2-Ylcarbonyl) Piperazine Methanesulfonate
• 1-(4-Amino-6,7-Dimethoxy-2-Quinazolinyl)-4-[4-(1,4-Benzodioxan-2-Yl)Carpiperazin-1-Yl)]-6,7-Dimethoxyquinazoline Mesylate
• 2-[4-(2,3-Dihydro-1,4-benzodioxine-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine; methanesulfonic acid
• Alfadil
• Cardenalin
• Cardran
• Cardular
• Cardura
• Cardura (pharmaceutical)
• Cardura XL
• Carduran
• Diblocin
• Dosin
• Doxacard
• Doxacor
• Doxazolazine Mesylate
• Doxazosin Mesilate
• Doxazosin Methanesulfonate
• Doxazosin Meylate
• Doxazosin monomethanesulfonate
• Methanone, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](2,3-dihydro-1,4-benzodioxin-2-yl)-, methanesulfonate (1:1)
• Normothen
• Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]-, monomethanesulfonate
• Supressin
• Uk-33274-27
• Doxazosin, Mesylate

Doxazosin Mesylate

CAS: 74191-85-8, 77883-43-3

Formula: C₂₃H₂₅N₅O₅·CH₄O₃S

Purity: >98.0%(HPLC)(N)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 547.58

Ref: 3B-D4126

Doxazosin impurity standard

CAS: 77883-43-3

Doxazosin impurity standard

Color and Shape: Off White

Ref: 47-1301

Doxazosin mesilate

CAS: 77883-43-3

Doxazosin mesilate

Formula: C₂₄H₂₉N₅O₈S

Purity: 99.2%

Color and Shape: Off-White

Molecular weight: 547.17368

Ref: 47-1300

DOXAZOSIN MESILATE CRS

CAS: 77883-43-3

DOXAZOSIN MESILATE CRS

Formula: C₂₃H₂₅N₅O₅

Color and Shape: Powder

Molecular weight: 451.4751

Ref: 41-Y0000553

Doxazosin Mesylate

CAS: 77883-43-3

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₂₃H₂₅N₅O₅·CH₄O₃S

Color and Shape: White Tan Powder

Molecular weight: 547.58 g/mol

Ref: 45-1225419

Doxazosin mesylate

CAS: 77883-43-3

Doxazosin mesylate (UK 33274 mesylate)(UK 33274) is a quinazoline-derivative. It is a selectively antagonizes postsynaptic α1-adrenergic receptors.

Formula: C₂₄H₂₉N₅O₈S

Purity: 99.92%

Color and Shape: White To Off-White Crystalline Powder

Molecular weight: 547.58

Ref: TM-T0101

Doxazosin mesylate

CAS: 77883-43-3

Doxazosin mesylate

Purity: ≥98%

Molecular weight: 547.58g/mol

Ref: 54-BUP17728

Doxazosin Mesylate

CAS: 77883-43-3

Formula: C₂₃H₂₅N₅O₅·CH₄O₃S

Molecular weight: 451.48 96.10

Ref: 4Z-D-1415

Doxazosin Mesylate

CAS: 77883-43-3

Doxazosin Mesylate

Purity: 99%

Molecular weight: 547.58g/mol

Ref: 54-OR1028228

Doxazosin Mesilate

CAS: 77883-43-3

Color and Shape: Neat

Ref: 86-MM0386.00

Doxazosin mesylate

CAS: 77883-43-3

Formula: C₂₃H₂₅N₅O₅·CH₃SO₃H

Purity: (HPLC) ≥ 97.0%

Color and Shape: White to off-white powder

Molecular weight: 547.58

Ref: 7W-GP9708

Doxazosin Mesilate RS

CAS: 77883-43-3

Color and Shape: White Solid Crystalline Powder

Ref: 2K-1086800021

Doxazosin Mesylate

CAS: 77883-43-3

Stability Light Sensitive
Applications Doxazosin is a selective α1-adrenoceptor antagonist. Doxazosin relaxes smooth muscles of the prostate.
References Elliott, H.L., et al.: Brit. J. Clin. Pharmacol., 13, 699 (1982), de Leeuw, P.W., et al.: Eur. J. Clin. Pharmacol., 23, 397 (1982),

Formula: C₂₃H₂₅N₅O₅·CH₄O₃S

Color and Shape: White To Off-White

Molecular weight: 547.58

Ref: TR-D537500

Doxazosin mesylate - Bio-X ™

CAS: 77883-43-3

Doxazosin is a first-generation α1-adrenergic receptor antagonist that is used in the treatment of hypertension and urinary obstruction, It has been shown to be effective in combination therapy for patients with benign prostatic hyperplasia.

Formula: C₂₃H₂₅N₅O₅•CH₄O₃S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 547.58 g/mol

Ref: 3D-BD164387

Doxazosin mesylate

CAS: 77883-43-3

α1-adrenoceptor blocker; anti-hypertensive agent

Formula: C₂₄H₂₉N₅O₈S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 547.58 g/mol

Ref: 3D-FD22603

Doxazosin Mesilate

CAS: 77883-43-3

Color and Shape: Neat

Ref: 61-FOR0386.00