CAS 78-41-1

Triparanol

Description:

Triparanol, with the CAS number 78-41-1, is an organic compound that belongs to the class of cholesterol synthesis inhibitors. It is primarily recognized for its role as a hypocholesterolemic agent, which means it is used to lower cholesterol levels in the body. Triparanol functions by inhibiting the enzyme 7-dehydrocholesterol reductase, thereby interfering with the biosynthesis of cholesterol. This compound is a white to off-white crystalline solid that is sparingly soluble in water but soluble in organic solvents. Its molecular formula is C27H45NO, and it has a relatively high molecular weight. Triparanol was historically used in the treatment of hypercholesterolemia; however, its clinical use has diminished due to side effects and the development of more effective cholesterol-lowering medications. Additionally, it has been associated with certain adverse effects, including cataract formation, which led to its withdrawal from the market in many regions. As a chemical substance, it is important to handle Triparanol with care, following appropriate safety protocols.

Formula: C₂₇H₃₂ClNO₂

InChI: InChI=1S/C27H32ClNO2/c1-4-29(5-2)18-19-31-26-16-12-24(13-17-26)27(30,23-10-6-21(3)7-11-23)20-22-8-14-25(28)15-9-22/h6-17,30H,4-5,18-20H2,1-3H3

InChI key: InChIKey=SYHDSBBKRLVLFF-UHFFFAOYSA-N

SMILES: C(CC1=CC=C(Cl)C=C1)(O)(C2=CC=C(OCCN(CC)CC)C=C2)C3=CC=C(C)C=C3

Synonyms:

• 1-(4-(2-(Diethylamino)ethoxy)phenyl)-1-(p-tolyl)-2-(p-chlorophenyl)ethanol
• 1-(p-(beta-Diethylaminoethoxy)phenyl)-1-(p-tolyl)-2-(p-chlorophenyl)ethanol
• 1-[p-(β-Diethylaminoethoxy)phenyl]-1-(p-tolyl)-2-(p-chlorophenyl)ethanol
• 2-(4-Chlorophenyl)-1-{4-[2-(Diethylamino)Ethoxy]Phenyl}-1-(4-Methylphenyl)Ethanol
• 2-(p-Chlorophenyl)-1-(p-(beta-diethylaminoethoxy)phenyl)-1-(p-tolyl)ethanol
• 2-(p-Chlorophenyl)-1-[p-(β-diethylaminoethoxy)phenyl]-1-(p-tolyl)ethanol
• 2-p-Chlorophenyl-1-(p-(2-diethylaminoethoxy)phenyl)-1-p-tolylethanol
• 4-Chloro-α-[4-[2-(diethylamino)ethoxy]phenyl]-α-(4-methylphenyl)benzeneethanol
• Acosterina
• Benzeneethanol, 4-chloro-alpha-(4-(2-(diethylamino)ethoxy)phenyl)-alpha-(4-methylphenyl)- (9CI)
• Benzeneethanol, 4-chloro-α-[4-[2-(diethylamino)ethoxy]phenyl]-α-(4-methylphenyl)-
• Brn 2064866
• Clotrox
• Diticyl
• Drenaren
• Ethanol, 2-(p-chlorophenyl)-1-(p-(2-(diethylamino)ethoxy)phenyl)-1-p-tolyl-
• Hipocolestina
• MER 2p
• Mer 29
• Metasclene
• Metasqualene
• Nsc 65345
• Sclane
• Trianel
• Trikosterol
• Triparanol [INN:BAN]
• Triparanolo
• Triparanolo [DCIT]
• Triparanolum
• Triparanolum [INN-Latin]
• Triparin
• Tropalin
• Valip
• Verdiana
• alpha-(p-Chlorobenzyl)-4-diethylaminoethoxy-4'-methylbenzhydrol

Triparanol

CAS: 78-41-1

Formula: C₂₇H₃₂ClNO₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 438.0015

Ref: IN-DA0053JN

Triparanol

CAS: 78-41-1

Formula: C₂₇H₃₂NO₂Cl

Molecular weight: 438.00

Ref: 7W-GP7426

Triparanol

CAS: 78-41-1

Triparanol

Purity: ≥98%

Molecular weight: 438g/mol

Ref: 54-BUP12318

Triparanol

Controlled Product

CAS: 78-41-1

Formula: C₂₇H₃₂ClNO₂

Color and Shape: Neat

Molecular weight: 438.00

Ref: TR-T808250

Triparanol

Controlled Product

CAS: 78-41-1

Triparanol is a cholesterol-lowering agent that inhibits the synthesis of cholesterol by blocking the enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase. It also has cytostatic and anti-cancer activities, with a marked effect on experimental animals. Triparanol has been shown to be toxic to the bowel and can cause bowel disease in humans. The drug blocks the synthesis of cholesterol by inhibiting the enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase, leading to a decrease in serum cholesterol levels. It also has cytostatic and anti-cancer activities, with a marked effect on experimental animals. Triparanol has been shown to be toxic to the bowel and can cause bowel disease in humans.

Formula: C₂₇H₃₂ClNO₂

Purity: Min. 95%

Molecular weight: 438 g/mol

Ref: 3D-FT28574

Triparanol

CAS: 78-41-1

Triparanol (NSC-65345) interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1

Formula: C₂₇H₃₂ClNO₂

Purity: 99.72%

Color and Shape: Solid

Molecular weight: 438

Ref: TM-T26296