CAS 78113-36-7

Romurtide

Description:

Romurtide, with the CAS number 78113-36-7, is a synthetic peptide that has been investigated for its potential therapeutic applications, particularly in the field of immunology and oncology. It is known for its ability to stimulate the immune system, specifically enhancing the activity of T-cells and natural killer cells, which play crucial roles in the body's defense against tumors and infections. Romurtide is often classified as an immunomodulator and has been studied for its effects on various types of cancer, as well as its potential to improve immune responses in patients undergoing chemotherapy. The substance is typically administered via injection and has been evaluated in clinical trials for its safety and efficacy. As with many peptides, its stability and bioavailability can be influenced by factors such as formulation and delivery method. Overall, Romurtide represents a promising area of research in the development of immunotherapeutic strategies.

Formula: C₄₃H₇₈N₆O₁₃

InChI: InChI=1/C43H78N6O13/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23-34(52)45-26-21-20-22-32(42(58)59)48-35(53)25-24-31(39(44)55)49-40(56)28(2)46-41(57)29(3)61-38-36(47-30(4)51)43(60)62-33(27-50)37(38)54/h28-29,31-33,36-38,43,50,54,60H,5-27H2,1-4H3,(H2,44,55)(H,45,52)(H,46,57)(H,47,51)(H,48,53)(H,49,56)(H,58,59)/t28-,29+,31+,32+,33+,36+,37+,38+,43?/m0/s1

InChI key: InChIKey=IKSJCVFYCIKDTB-GZZWOGMVSA-N

SMILES: [C@H]([C@@H](NC(C)=O)C=O)(O[C@@H](C(N[C@H](C(N[C@H](CCC(N[C@@H](CCCCNC(CCCCCCCCCCCCCCCCC)=O)C(O)=O)=O)C(N)=O)=O)C)=O)C)[C@@H]([C@@H](CO)O)O

Synonyms:

• (2R)-2-{[(4R)-4-{[(2S)-2-{[(2R)-2-{[(3R,4R,5S,6R)-3-(acetylamino)-2,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]oxy}propanoyl]amino}propanoyl]amino}-5-amino-5-oxopentanoyl]amino}-6-(octadecanoylamino)hexanoic acid (non-preferred name)
• 1: PN: WO2009033811 PAGE: 103 claimed protein
• <span class="text-smallcaps">L</smallcap>-Lysine, N-(N-acetylmuramoyl)-<smallcap>L</smallcap>-alanyl-<smallcap>D</span>-α-glutaminyl-N⁶-(1-oxooctadecyl)-
• <span class="text-smallcaps">L</smallcap>-Lysine, N²-[N²-[N-(N-acetylmuramoyl)-<smallcap>L</smallcap>-alanyl]-<smallcap>D</span>-α-glutaminyl]-N⁶-(1-oxooctadecyl)-
• Ac-Muramyl-Ala-D-Glu(Lys(Stearoyl)-Oh)-Nh2
• Dj 7041
• MDP-Lys(L 18)
• Muroctasin
• Muroctasine
• N-(N-Acetylmuramoyl)-<span class="text-smallcaps">L</smallcap>-alanyl-<smallcap>D</smallcap>-α-glutaminyl-N⁶-(1-oxooctadecyl)-<smallcap>L</span>-lysine
• N^α-Acetylmuramoyl-<span class="text-smallcaps">L</smallcap>-alanyl-<smallcap>D</smallcap>-isoglutaminyl-N^ε-stearoyl-<smallcap>L</span>-lysine
• Nopia
• Romurtide
• N-(N-Acetylmuramoyl)-L-alanyl-D-α-glutaminyl-N6-(1-oxooctadecyl)-L-lysine
• L-Lysine, N2-[N2-[N-(N-acetylmuramoyl)-L-alanyl]-D-α-glutaminyl]-N6-(1-oxooctadecyl)-
• L-Lysine, N-(N-acetylmuramoyl)-L-alanyl-D-α-glutaminyl-N6-(1-oxooctadecyl)-
• Nα-Acetylmuramoyl-L-alanyl-D-isoglutaminyl-Nε-stearoyl-L-lysine
• C13187
• N2-[(N-Acetylmuramoyl)-L-Ala-D-γGln-]-N6-stearoyl-L-Lys-OH
• n(sup2)-((n-acetylmuramoyl)-l-alanyl-d-isoglutaminyl)-n(sup6)-stearoyl-l-ly
• N-acetylmuramyl-ala-D-isoglutaminyl-*N-epsilon-st
• l-lysine,n(sup2),(n(sup2)-(n-(n-acetylmuramoyl)-l-alanyl)-d-alpha-glutaminyl
• N^<2>^-[N^<2>^-[N-(N-Acetylmuramoyl)-L-alanyl]-D-α-glutaminyl]-N^<6>^-(1-oxooctadecyl)-L-lysine
• n-acetylmuramyl-ala-d-isoglutaminyl-nε-stearoyl-lys
• Ac-muramyl-Ala-D-Glu(Lys(stearoyl)-OH)-NH
• Ac-MuraMyl-Ala-D-Isogln-Lys(stearoyl)-OH, Muroctasin, RoMurtide, MDP-Lys(L 18)
• N-Acetylmuramyl-alanyl-D-isoglutaminyl-N'-stearoyl-lysine
• Na-Acetylmuramyl-L-alanyl-D-isoglutaminyl-Ne-stearoyl-L-lysine
• )-n(sup6)-(1-oxooctadecyl)-
• N2-[(R)-5-Amino-4-[[N-(N-acetylmuramoyl)-L-alanyl]amino]-1,5-dioxopentyl]-N6-stearoyl-L-lysine
• Muroetasin
• L-Lysine, N-(N-acetylmuramoyl)-L-alanyl-D-a-glutaminyl-N6-(1-oxooctadecyl)- (9CI)
• N-ACETYLMURAMYL-ALA-D-ISOGLUTAMINYL-N-EP SILON-STEA
• Ac-muramyl-A
• Romurtide USP/EP/BP
• AC-MURAMYL-ALA-D-ISOGLN-LYS(STEAROYL)-OH

Ac-muramyl-Ala-D-Glu(Lys(stearoyl)-OH)-NH₂

CAS: 78113-36-7

The investigation of the adjuvant activity of this muramyl peptide on humoral and cellular immune responses showed that it augments the mitogenic responses of splenic lymphocytes to phytohemagglutinin and lipopolysaccharide and the formation of antibodies to sheep erythrocytes in mice. In addition, it potentiated polyclonal B cell activation in vivo and in vitro.

Formula: C₄₃H₇₈N₆O₁₃

Purity: > 98%

Color and Shape: White Powder

Molecular weight: 887.13

Ref: 01-4015937

Romurtide

CAS: 78113-36-7

Romurtide is a synthetic muramyl dipeptide analog and can be used for the prophylaxis of leukocytopenia during radiation therapy.

Formula: C₄₃H₇₈N₆O₁₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 887.126

Ref: TM-TP2405

Romurtide

CAS: 78113-36-7

Formula: C₄₃H₇₈N₆O₁₃

Purity: ≥ 98.0%

Color and Shape: White powder

Molecular weight: 887.11

Ref: 7W-GP1044

Ac-muramyl-Ala-D-Glu(Lys(stearoyl)-OH)-NH2

CAS: 78113-36-7

Ac-muramyl-Ala-D-Glu(Lys(stearoyl)-OH)-NH2 is a synthetic peptide that was designed to mimic the sequence of muramyl dipeptide (MDP), which is found in bacterial cell walls. Ac-muramyl-Ala-D-Glu(Lys(stearoyl)-OH)-NH2 binds to the protein albumin, which is an important component of human blood plasma and has been shown to be elevated in patients with autoimmune diseases. This peptide also inhibits the activity of metal hydroxides, such as aluminum hydroxide and calcium hydroxide, by binding to their surface, reducing their antimicrobial activity. The effect on locomotor activity has not been studied. Ac-muramyl-Ala-D-Glu(Lys(stearoyl)-OH)-NH2 may have effects on various cells types including macrophages and T

Formula: C₄₃H₇₈N₆O₁₃

Purity: Min. 95%

Color and Shape: Solid

Molecular weight: 887.11 g/mol

Ref: 3D-FA110464