CAS 783292-37-5

trans-Abacavir Dihydrochloride

Controlled Product

CAS: 267668-71-3, 783292-37-5

Applications trans-Abacavir Dihydrochloride is an impurity of Abacavir. Abacavir (A104990) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)

Formula: C₁₄H₁₈N₆O·2HCl

Color and Shape: Neat

Molecular weight: 359.25

Ref: TR-A104995

(1R,​4R)​-​rel-4-​[2-Amino-​6-​(cyclopropylamino)​-​9H-​purin-​9-​yl]​-​2-​cyclopentene-​1-​methanol

Controlled Product

CAS: 783292-37-5

Formula: C₁₄H₁₈N₆O

Color and Shape: Neat

Molecular weight: 286.332

Ref: TR-A634440