CAS 783355-60-2

Abexinostat

Description:

Abexinostat is a small molecule inhibitor primarily known for its role as a histone deacetylase (HDAC) inhibitor, which is significant in the field of cancer therapy. It is characterized by its ability to modulate gene expression by altering the acetylation status of histones, thereby influencing cellular processes such as proliferation, differentiation, and apoptosis. Abexinostat has been investigated for its potential efficacy in treating various malignancies, including hematological cancers and solid tumors. The compound is typically administered orally and has shown promise in preclinical and clinical studies, often in combination with other therapeutic agents to enhance anti-tumor activity. Its chemical structure includes a core that allows for interaction with the HDAC enzyme, leading to the inhibition of its activity. As with many HDAC inhibitors, the therapeutic application of Abexinostat is accompanied by a profile of potential side effects, which necessitates careful monitoring during treatment. Overall, Abexinostat represents a valuable addition to the arsenal of targeted cancer therapies.

Formula: C₂₁H₂₃N₃O₅

InChI: InChI=1S/C21H23N3O5/c1-24(2)13-17-16-5-3-4-6-18(16)29-19(17)21(26)22-11-12-28-15-9-7-14(8-10-15)20(25)23-27/h3-10,27H,11-13H2,1-2H3,(H,22,26)(H,23,25)

InChI key: InChIKey=MAUCONCHVWBMHK-UHFFFAOYSA-N

SMILES: C(N(C)C)C=1C=2C(OC1C(NCCOC3=CC=C(C(NO)=O)C=C3)=O)=CC=CC2

Synonyms:

• 2-Benzofurancarboxamide, 3-[(dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-
• 3-[(Dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-2-benzofurancarboxamide
• Abexinostat
• Brd K12867552
• Cra 024781
• Cra 24781
• Pci 24781
• Thm-I 94

Abexinostat

CAS: 783355-60-2

Abexinostat (PCI-24781) is a pan-HDAC inhibitor, strongest on HDAC1; less so on HDACs 2, 3, 6, 10. Very select for HDAC8. In Phase 1/2 trials.

Formula: C₂₁H₂₃N₃O₅

Purity: 98.19% - 98.43%

Color and Shape: White Solid

Molecular weight: 397.42

Ref: TM-T0431

CRA-02478

CAS: 783355-60-2

Formula: C₂₁H₂₃N₃O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 397.4244

Ref: IN-DA00G3PG

Abexinostat

CAS: 783355-60-2

Abexinostat

Formula: C₂₁H₂₃N₃O₅

Purity: ≥98%

Molecular weight: 397.42

Ref: 54-BUP01893

3-((Dimethylamino)Methyl)-N-(2-(4-(Hydroxycarbamoyl)Phenoxy)Ethyl)Benzofuran-2-Carboxamide

CAS: 783355-60-2

3-((Dimethylamino)Methyl)-N-(2-(4-(Hydroxycarbamoyl)Phenoxy)Ethyl)Benzofuran-2-Carboxamide

Formula: C₂₁H₂₃N₃O₅

Purity: 98%

Molecular weight: 397.42

Ref: 54-OR1026175

Abexinostat

CAS: 783355-60-2

3-((Dimethylamino)methyl)-N-(2-(4-(hydroxycarbamoyl)phenoxy)ethyl)benzofuran-2-carboxamide

Formula: C₂₁H₂₃N₃O₅

Purity: 98%

Molecular weight: 397.42

Ref: IN-DG304661

PCI-24781

CAS: 783355-60-2

Formula: C₂₁H₂₃N₃O₅

Purity: 95.0%

Molecular weight: 397.431

Ref: 10-F390271

Abexinostat

CAS: 783355-60-2

Purity: 98%

Molecular weight: 397.431

Ref: 10-F979046

PCI-24781

CAS: 783355-60-2

Applications PCI-24781 is a novel hydroxamic acid HDAC inhibitor (histone deacetylase inhibitor).  PCI-24781 exerts cytotoxicity and histone H3 alterations via caspase-8 and FADD in leukemia cells.
References Morales, V., et al.: Mol. Cell Biol., 20, 7230 (2000), Th'ng, J., et al.: J. Biol. Chem., 280, 27809 (2005), Esteller, M., et al.: Carcinogenesis, 27, 1121 (2006),

Formula: C₂₁H₂₃N₃O₅

Color and Shape: Neat

Molecular weight: 397.4244

Ref: TR-P216400

PCI 24781

CAS: 783355-60-2

HDAC enzyme inhibitor; antineoplastic

Formula: C₂₁H₂₃N₃O₅

Purity: Min. 95%

Molecular weight: 397.42 g/mol

Ref: 3D-FP26773