CAS 78613-38-4

Amorolfine hydrochloride

Description:

Amorolfine hydrochloride is an antifungal agent primarily used in the treatment of onychomycosis, a fungal infection of the nails. It belongs to the morpholine class of compounds and exhibits broad-spectrum antifungal activity against various dermatophytes, yeasts, and molds. The substance works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, thereby disrupting their integrity and function. Amorolfine hydrochloride is typically formulated as a topical solution or nail lacquer, allowing for localized treatment with minimal systemic absorption. Its efficacy is enhanced by its ability to penetrate the nail plate, providing sustained antifungal action. The compound is generally well-tolerated, with few side effects, although local irritation may occur in some patients. As with any medication, it is important to follow the prescribed guidelines for use to ensure optimal results and minimize the risk of resistance development. Overall, Amorolfine hydrochloride represents a valuable option in the management of nail fungal infections.

Formula: C₂₁H₃₅NO·ClH

InChI: InChI=1/C21H35NO.ClH/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22;/h8-11,16-18H,7,12-15H2,1-6H3;1H/t16?,17-,18+;

InChI key: InChIKey=XZKWIPVTHGWDCF-KUZYQSSXNA-N

SMILES: C(C(CN1C[C@H](C)O[C@H](C)C1)C)C2=CC=C(C(CC)(C)C)C=C2.Cl

Synonyms:

• (2R,6S)-2,6-dimethyl-4-{2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl}morpholine
• (2R,6S)-2,6-dimethyl-4-{2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl}morpholine hydrochloride (1:1)
• Amorolfine HCI
• Amorolfine Hcl
• Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, hydrochloride
• Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, hydrochloride (1:1), (2R,6S)-rel-
• Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, hydrochloride, (2R,6S)-rel-
• Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, hydrochloride, cis-
• Ro 14-4767/002
• Amorolfine hydrochloride

AMOROLFINE HYDROCHLORIDE CRS

CAS: 78613-38-4

AMOROLFINE HYDROCHLORIDE CRS

Formula: C₂₁H₃₆ClNO

Color and Shape: White. Whitish. Crystalline Powder.

Molecular weight: 353.9696

Ref: 41-Y0001794

AMOROLFINE FOR SYSTEM SUITABILITY CRS

CAS: 78613-38-4

AMOROLFINE FOR SYSTEM SUITABILITY CRS

Formula: C₂₁H₃₆ClNO

Color and Shape: White. Whitish. Crystalline Powder.

Molecular weight: 353.9696

Ref: 41-Y0001795

Amorolfine hydrochloride

CAS: 78613-38-4

Amorolfine hydrochloride (Amorolfine HCl) is an antifungal reagent.

Formula: C₂₁H₃₆ClNO

Purity: 99.05% - >99.99%

Color and Shape: White Powder

Molecular weight: 353.97

Ref: TM-T0187

Amorolfine Hydrochloride

CAS: 78613-38-4

Formula: C₂₁H₃₆ClNO

Purity: 98%

Color and Shape: Solid

Molecular weight: 353.9696

Ref: IN-DA003NVY

Amorolfine-d4 HCl

CAS: 78613-38-4

Formula: C₂₁H₃₁D₄NO·HCl

Molecular weight: 321.54 36.46

Ref: 4Z-A-7328

Amorolfine Hcl

CAS: 78613-38-4

Amorolfine Hcl

Purity: 98%

Molecular weight: 353.98g/mol

Ref: 54-OR1027411

Amorolfine HCl

CAS: 78613-38-4

Formula: C₂₁H₃₅NO·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 317.52 36.46

Ref: 4Z-A-731

Amorolfine hydrochloride

CAS: 78613-38-4

Amorolfine hydrochloride

Purity: ≥98%

Molecular weight: 353.97g/mol

Ref: 54-BUP17062

Amorolfine hydrochloride

CAS: 78613-38-4

Formula: C₂₁H₃₅ON·HCl

Purity: ≥ 99.0%

Color and Shape: White powder

Molecular weight: 353.97

Ref: 7W-GP0831

Amorolfine Hydrochloride

CAS: 78613-38-4

Formula: C₂₁H₃₅NO·HCl

Purity: >98.0%(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 353.98

Ref: 3B-A2161

Amorolfine Hydrochloride

Controlled Product

CAS: 78613-38-4

Formula: C₂₁H₃₅NO·ClH

Color and Shape: Neat

Molecular weight: 353.97

Ref: 86-MM3511.00

Amorolfine Hydrochloride

CAS: 78613-38-4

Applications Amorolfine hydrochloride is a salt of Amorolfine which is a morpholine antifungal drug. It is a topical solution for the treatment of toenail infections.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rotta, I., et al.: JAMA Dermatol., 149, 341 (2013); Espinel-Ingroff, A., et al.: Antimicrob. Agents Ch., 26, 5 (1984)

Formula: C₂₁H₃₅NO·ClH

Color and Shape: Off-White

Molecular weight: 353.97

Ref: TR-A634170

Amorolfine HCl - Bio-X ™

CAS: 78613-38-4

Amorolfine is an antifungal drug that inhibits fungal enzymes (D14 reductase and D7-D8 isomerase). Its inhibition has an affect on fungal sterol synthesis pathways, and it depletes ergosterol. This drug can be used as a treatment for inflammatory lesions such as Tinea corporis, Tinea pedis, and Tinea cruris due to its ability to penetrate the skin barrier with ease.

Formula: C₂₁H₃₅NO•HCl

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 353.97 g/mol

Ref: 3D-BA164168

Amorolfine hydrochloride

CAS: 78613-38-4

Anti-fungal agent; inhibits ergosterol biosynthesis

Formula: C₂₁H₃₅ON•HCl

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 353.97 g/mol

Ref: 3D-FA64941

Amorolfine Hydrochloride

CAS: 78613-38-4

Purity: ≥98%(HPLC)

Molecular weight: 353.980011

Ref: 10-F862725

Amorolfine EP Impurity K

CAS: 78613-38-4

Formula: C₂₂H₃₇NO

Color and Shape: White To Off-White Solid

Molecular weight: 331.54

Ref: 4Z-A-7315