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CAS 78613-38-4

:

Amorolfine hydrochloride

Description:
Amorolfine hydrochloride is an antifungal agent primarily used in the treatment of onychomycosis, a fungal infection of the nails. It belongs to the morpholine class of compounds and exhibits broad-spectrum antifungal activity against various dermatophytes, yeasts, and molds. The substance works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, thereby disrupting their integrity and function. Amorolfine hydrochloride is typically formulated as a topical solution or nail lacquer, allowing for localized treatment with minimal systemic absorption. Its efficacy is enhanced by its ability to penetrate the nail plate, providing sustained antifungal action. The compound is generally well-tolerated, with few side effects, although local irritation may occur in some patients. As with any medication, it is important to follow the prescribed guidelines for use to ensure optimal results and minimize the risk of resistance development. Overall, Amorolfine hydrochloride represents a valuable option in the management of nail fungal infections.
Formula:C21H35NO·ClH
InChI:InChI=1/C21H35NO.ClH/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22;/h8-11,16-18H,7,12-15H2,1-6H3;1H/t16?,17-,18+;
InChI key:InChIKey=XZKWIPVTHGWDCF-KUZYQSSXNA-N
SMILES:C(C(CN1C[C@H](C)O[C@H](C)C1)C)C2=CC=C(C(CC)(C)C)C=C2.Cl
Synonyms:
  • (2R,6S)-2,6-dimethyl-4-{2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl}morpholine
  • (2R,6S)-2,6-dimethyl-4-{2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl}morpholine hydrochloride (1:1)
  • Amorolfine HCI
  • Amorolfine Hcl
  • Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, hydrochloride
  • Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, hydrochloride (1:1), (2R,6S)-rel-
  • Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, hydrochloride, (2R,6S)-rel-
  • Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, hydrochloride, cis-
  • Ro 14-4767/002
  • Amorolfine hydrochloride
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