CAS 78755-81-4
:Flumazenil
Description:
Flumazenil is a benzodiazepine derivative primarily known for its role as a competitive antagonist of the benzodiazepine receptor. It is commonly used in clinical settings to reverse the effects of benzodiazepine overdose or sedation. The substance is characterized by its ability to displace benzodiazepines from their binding sites on the GABA-A receptor, thereby counteracting their sedative effects. Flumazenil is typically administered intravenously and has a relatively short half-life, which necessitates careful monitoring and potential repeated dosing in cases of overdose. Its chemical structure includes a 1,3-benzodiazepine core, contributing to its pharmacological properties. While it is effective in reversing sedation, flumazenil can precipitate withdrawal symptoms in individuals dependent on benzodiazepines and may not be effective against all types of sedative overdoses. Additionally, it is contraindicated in patients with a history of seizures or those who have taken certain medications, such as tricyclic antidepressants. Overall, flumazenil is a critical tool in emergency medicine for managing benzodiazepine-related complications.
Formula:C15H14FN3O3
InChI:InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3
InChI key:InChIKey=OFBIFZUFASYYRE-UHFFFAOYSA-N
SMILES:C(OCC)(=O)C1=C2N(C=3C(C(=O)N(C)C2)=CC(F)=CC3)C=N1
Synonyms:- 4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 8-fluoro-5,6-dihydro-5-methyl-6-oxo-, ethyl ester
- 8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-
- Anexate
- FMZ
- Flumazepil
- Flumenazil
- Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic
- Lanexat
- Mazicon
- Ro 15-1788
- Ro 15-1788/000
- Ro 151788
- Ro 1722
- Ro 41-8157
- Romazicon
- acid ethyl ester
- ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
- 8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-
- Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic
- acid ethyl ester
- See more synonyms
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Flumazenil
CAS:Formula:C15H14FN3O3Purity:>99.0%(GC)Color and Shape:White to Almost white powder to crystalMolecular weight:303.29Flumazenil, 98%
CAS:Benzodiazepine antagonistFormula:C15H14FN3O3Purity:98%Color and Shape:PowderMolecular weight:303.29Flumazenil
CAS:Aromatic or modified aromatic drugs with nitrogen hetero-atom(s) only, not elsewhere specified or includedFormula:C15H14FN3O3Color and Shape:White Off-White PowderMolecular weight:303.10192Flumazenil
CAS:Flumazenil (Ro 15-1788) antagonizes the benzodiazepine binding site of the gamma-aminobutyric acid (GABA)/benzodiazepine receptor complex in the central nervousFormula:C15H14FN3O3Purity:99.72% - 99.98%Color and Shape:Less Crystals Colourless CrystalsMolecular weight:303.29Ethyl 8-fluoro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
CAS:Formula:C15H14FN3O3Purity:95%Color and Shape:SolidMolecular weight:303.2884Flumazenil-d5
CAS:Formula:C15H9D5FN3O3Color and Shape:White To Off-White SolidMolecular weight:308.32Flumazenil
CAS:Formula:C15H14FN3O3Purity:≥ 98.0%Color and Shape:White to off-white powderMolecular weight:303.29Flumazenil
CAS:Controlled ProductApplications Flumazenil is an imidazodiazepine which selectively blocks the central effects of classic benzodiazepines. It is used as benzodiazepine antagonist.
References Hunkeler, W., et al.: Nature, 290, 514 (1981), Pole, P., et al.: Arch. Pharmacol., 316, 317 (1981), Timm, U., et al.: Arzneim.-Forsch., 33, 358 (1983),Formula:C15H14FN3O3Color and Shape:Off WhiteMolecular weight:303.29Flumazenil-D5
CAS:Controlled ProductApplications Flumazenil-D5 is a labelled analogue of Flumazenil (F500450), a benzodiazepine antagonist that can prevent or abolish (at the receptor level) the effects of a benzodiazepine.
References Brogden, R. & Goa, K.: Drugs, 35, 448 (1988); Klotz, U. & Kanto, J.: Clin. Pharmacokinet., 14, 1 (1988)Formula:C15H9D5FN3O3Color and Shape:NeatMolecular weight:303.29Flumazenil
CAS:Controlled ProductBenzodiazepine antagonistFormula:C15H14FN3O3Purity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:303.29 g/mol
![Ethyl 8-fluoro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA005JF1.jpg&w=3840&q=75)
