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CAS 79794-75-5

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Loratadine

Description:
Loratadine is a second-generation antihistamine commonly used to relieve allergy symptoms such as runny nose, sneezing, and itchy eyes. It is characterized by its selective antagonism of peripheral H1 receptors, which helps to minimize common side effects associated with first-generation antihistamines, such as sedation. Loratadine is a white to off-white crystalline powder that is practically insoluble in water but soluble in organic solvents like ethanol and methanol. Its chemical formula is C22H23ClN2O2, and it has a molecular weight of approximately 382.88 g/mol. Loratadine is often administered orally and has a long duration of action, allowing for once-daily dosing. It is metabolized in the liver to its active metabolite, desloratadine, which contributes to its antihistaminic effects. Due to its low penetration of the blood-brain barrier, loratadine is less likely to cause drowsiness compared to older antihistamines, making it a preferred choice for individuals needing relief from allergic symptoms without sedation.
Formula:C22H23ClN2O2
InChI:InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
InChI key:InChIKey=JCCNYMKQOSZNPW-UHFFFAOYSA-N
SMILES:ClC=1C=C2C(C(C=3C(CC2)=CC=CN3)=C4CCN(C(OCC)=O)CC4)=CC1
Synonyms:
  • 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-, ethyl ester
  • 11H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 1-piperidinecarboxylic acid deriv.
  • 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester
  • Alavert
  • Anhissen
  • Bonalerg
  • Civeran
  • Claratyne
  • Claritin
  • Claritine
  • See more synonyms
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