CAS 79902-63-9
:Simvastatin
Description:
Simvastatin is a synthetic lipid-lowering agent belonging to the class of statins, primarily used to manage hyperlipidemia and reduce the risk of cardiovascular disease. Its chemical structure features a lactone ring and a hydroxy acid moiety, which are crucial for its biological activity. The substance works by inhibiting HMG-CoA reductase, an enzyme involved in cholesterol biosynthesis in the liver, thereby lowering levels of low-density lipoprotein (LDL) cholesterol and triglycerides while modestly increasing high-density lipoprotein (HDL) cholesterol. Simvastatin is typically administered orally and is known for its relatively high bioavailability, although it undergoes extensive first-pass metabolism in the liver. Common side effects may include muscle pain, liver enzyme abnormalities, and gastrointestinal disturbances. It is important to monitor liver function and muscle health during treatment. Simvastatin is often prescribed in conjunction with lifestyle modifications, such as diet and exercise, to enhance its cholesterol-lowering effects. As with all medications, it is essential to use simvastatin under the guidance of a healthcare professional.
Formula:C25H38O5
InChI:InChI=1/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21?,23?/m0/s1
InChI key:InChIKey=RYMZZMVNJRMUDD-HGQWONQESA-N
SMILES:O(C(C(CC)(C)C)=O)[C@@H]1[C@]2(C(C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(=O)O3)=C[C@H](C)C1)[H]
Synonyms:- (+)-Simvastatin
- Apo-Simva
- Apo-Simvastatin
- Bestatin 20
- Butanoic acid, 2,2-dimethyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester, [1S-[1α,3α,7β,8β(2S*,4S*),8aβ]]-
- Cholestat
- Co-Simvastatin
- Denan
- Egilipid
- Eucor
- Kolestevan
- L 644128-000U
- Lipex
- Lipinorm
- Liponorm
- Lipovas
- Lodales
- Lycostatin
- Mk 733
- Modutrol
- Nor-Vastina
- Novo-Simvastatin
- Pms-simvastatin
- Rechol
- Simastin 20
- Simcor
- Simcovas
- Simgal
- Simi 20
- Simlip
- Simlip 20
- Simlo 20
- Simlup 20
- Simovil
- Simratio
- Simvacard
- Simvachol
- Simvacor
- Simvahexal
- Simvas
- Simvastatin lactone
- Simvasterol
- Simvastol
- Simvofix
- Simvotin
- Sinvacor
- Sinvascor
- Sivastin
- Starstat 20
- Statin
- Synvinolin
- Valemia
- Vasilip
- Vastan
- Vazilip
- Velostatin
- Ximve
- Zocor
- Zocor Forte
- Zocord
- Zorced
- Zosta
- Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester
- [(3R,7S,8S)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-tetrahydropyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate
- (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl 2,2-dimethyl-butanoate
- Simvastatin USP23,24
- SIMVASTATIN,USP
- mk-0733
- butanoicacid,2,2-dimethyl-,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahy
- 2,2-DIMETHYL-BUTYRIC ACID (1S,3R,7S,8S,8AR)-8-[2-((2R,4R)-4-HYDROXY-6-OXO-TETRAHYDRO-PYRAN-2-YL)-ETHYL]-3,7-DIMETHYL-1,2,3,7,8,8A-HEXAHYDRO-NAPHTHALEN-1-YL ESTER
- l644128-000u
- SimvastatineUsp25
- SIMVASTATIN USP24
- (1s-(1-alpha,3-dro-4-hydroxy-6-oxo-2h-pyran-2-yl)ethyl)-1-naphthalenyleste
- Zocor, MK-733, Liponorm
- SimvastatinC25H3805
- 7-beta,8-beta(2s*,4s*),8a-beta))-alph
- 2,2-DIMETHYLBUTANOIC ACID 1,2,3,7,8,8A-HEXAHYDRO-3,7-DIMETHYL-8-[2-TETRAHYDRO-4-HYDROXY-2-OXO-2H-PYRAN-YL]-1-NAPHTHALENYL ESTER
- Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-2-(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-ylethyl-1-naphthalenyl ester
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Simvastatin
CAS:Formula:C25H38O5Purity:>97.0%(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:418.57Simvastatin
CAS:SimvastatinFormula:C25H38O5Purity:99.7%Color and Shape:Off-WhiteMolecular weight:418.27192SIMVASTATIN CRS
CAS:SIMVASTATIN CRSFormula:C25H38O5Color and Shape:Added ModifiedMolecular weight:418.5662Simvastatin
CAS:Aromatic lactones used as drugsFormula:C25H38O5Color and Shape:PowderMolecular weight:418.56 g/molSimvastatin
CAS:Simvastatin (MK 733) is an HMG-CoA reductase inhibitor (Ki=0.2 nM) with oral activity.Formula:C25H38O5Purity:98.54% - 99.88%Color and Shape:SolidMolecular weight:418.5662Simvastatin
CAS:Formula:C25H38O5Purity:≥ 98.0%Color and Shape:White to off-white powderMolecular weight:418.57Simvastatin (Standard)
CAS:Simvastatin (Standard) is a reference standard of the HMG-CoA reductase inhibitor simvastatin.Formula:C25H38O5Purity:98.3%Molecular weight:418.5662Simvastatin
CAS:M03997 - Simvastatin
Formula:C25H38O5Purity:98%Color and Shape:SolidMolecular weight:418.574Simvastatin 100 µg/mL in Acetonitrile
CAS:Formula:C25H38O5Color and Shape:Single SolutionMolecular weight:418.57Simvastatin
CAS:Controlled ProductApplications Simvastatin is a synthetic derivative of a fermentation product of Aspergillus terreus. A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic. Simvastatin, the drug, is sold under the trade name Zocor.
References Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986), Mol, M.J., et al.: Lancet, 2, 936 (1986),Formula:C25H38O5Color and Shape:NeatMolecular weight:418.57Simvastatin
CAS:(1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoateFormula:C25H38O5Purity:98%Molecular weight:418.57Simvastatin - Bio-X ™
CAS:Simvastatin is a lipid-lowering agent that belongs to the group of statins. It is prescribed for the treatment of hypercholesterolemia, coronary heart diseases, and other conditions related to high cholesterol levels. Simvastatin inhibits the production of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, an enzyme involved in the synthesis of cholesterol. Simvastatin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formula:C25H38O5Purity:(%) Min. 95%Color and Shape:PowderMolecular weight:418.57 g/mol
