CAS 80-92-2

Pregnanediol

Description:

Pregnanediol is a steroidal compound that serves as a significant metabolite of progesterone, a key hormone in the reproductive system. It is characterized by its chemical structure, which includes two hydroxyl (-OH) groups, making it a diol. Pregnanediol is typically found in the form of a colorless to pale yellow liquid or solid, depending on its purity and conditions. It is soluble in organic solvents but has limited solubility in water. This compound plays a crucial role in various biological processes, particularly in the metabolism of steroids and the regulation of reproductive functions. In clinical settings, pregnanediol levels can be measured to assess ovarian function and monitor pregnancy. Additionally, it is used in research to study hormonal pathways and the effects of steroid hormones on the body. Due to its biological significance, understanding the properties and behavior of pregnanediol is essential in both pharmacology and endocrinology.

Formula: C₂₁H₃₆O₂

InChI: InChI=1/C21H36O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h13-19,22-23H,4-12H2,1-3H3/t13-,14-,15-,16-,17-,18-,19-,20+,21-/m0/s1

InChI key: InChIKey=YWYQTGBBEZQBGO-BERLURQNSA-N

SMILES: C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@]([C@H](C)O)(CC4)[H])[H])(CC[C@@]1(C[C@H](O)CC2)[H])[H])[H]

Synonyms:

• (3alpha,5beta,20S)-pregnane-3,20-diol
• (3alpha,5beta,20alpha)-Pregnane-3,20-diol
• (3α,5β,20S)-Pregnane-3,20-diol
• 17-(1-hydroxyethyl)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
• 3-alpha,20-alpha-Dihydroxy-5-beta-pregnane
• 3alpha,20alpha-Dihydroxy-5beta-pregnane
• 3α,20α-Dihydroxy-5β-pregnane
• 5-beta-Pregnane, 3-alpha,20-alpha-dihydroxy-
• 5-beta-Pregnane-3-alpha, 20-alpha-diol
• 5-Β-Pregnano-3-Α-20-Α-Diol
• 5-β-Pregnan-3-α,20-α-diol
• 5beta-Pregnane, 3alpha,20alpha-dihydroxy-
• 5beta-Pregnane-3alpha,20alpha-diol (8CI)
• 5β-Pregnane-3α,20α-diol
• Brn 3083715
• Diol
• Diol (6CI,7CI)
• Nsc 1612
• Nsc 47462
• Pregnandiol
• Pregnandiol [JAN]
• Pregnane-3,20-diol
• Pregnane-3,20-diol, (3-alpha,5-beta,20S)- (9CI)
• Pregnane-3,20-diol, (3alpha,5beta,20S)- (9CI)
• Pregnane-3,20-diol, (3α,5β,20S)-
• Pregnane-3alpha,20alpha-diol
• Pregnanediol
• Unii-Jr3Jd1Y22C
• 4-06-00-06111 (Beilstein Handbook Reference)
• 5SS-PREGNANE-3ALPHA,20ALPHA-DIOL
• 5-BETA-PREGNAN-3-ALPHA, 20-ALPHA-DIOL
• (8S,9S,10S,13R,14S,17S)-17-ethyl-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-3,3-diol
• Pregnane-3,20-diol, (3a,5b,20S)- (9CI)
• 3a,20a-Dihydroxy-5pregnane
• THA
• 5BETA-PREGNANE-3ALPHA,20ALPHA-DIOL
• (3α,5β),20S)-
• (3a,5),20S)-Pregnane-3,20-diol
• 5b-Pregnane-3a,20a-diol (8CI)
• 5-Pregnane-3alpha,20alpha-diol
• 3-alpha,20-alpha-dihydroxy-5-beta-pregnan
• 3ALPHA,20ALPHA-Dihydroxy-5B-pregnane
• (20S)-3α,20-Dihydroxy-5β-pregnane
• (20S)-5β-Pregnan-3α,20-diol
• Pregnane-3,20-diol, (3.alpha.,5.beta.,20S)-
• 5BETA-PREGNAN-3A,20A-DIOL
• 5β-Pregnane-3α,20α-diol-d5
• 5BETA-PREGNANE-3ALPHA 20ALPHA-DIOL 98+%
• TETRAHYDRO COMPOUND ''A''

5β-Pregnane-3α,20α-diol

CAS: 80-92-2

Formula: C₂₁H₃₆O₂

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 320.52

Ref: 3B-P0678

Pregnanediol (5β-Pregnane-3α,20(S)-diol)

CAS: 80-92-2

Color and Shape: Neat

Ref: 61-FOR0222.14

5β-Pregnane-3α,20α-diol

CAS: 80-92-2

Formula: C₂₁H₃₆O₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 320.5093

Ref: IN-DA003472

Pregnanediol

CAS: 80-92-2

Formula: C₂₁H₃₆O₂

Molecular weight: 320.52

Ref: 4Z-P-462005

5Β-Pregnane-3Α,20Α-Diol

CAS: 80-92-2

5Β-Pregnane-3Α,20Α-Diol

Purity: 95%

Molecular weight: 320.52g/mol

Ref: 54-OR1023940

Pregnanediol

CAS: 80-92-2

Pregnanediol

Purity: ≥98%

Molecular weight: 320.51g/mol

Ref: 54-BUP11432

Pregnanediol (5β-Pregnane-3α,20(S)-diol)

Controlled Product

CAS: 80-92-2

Formula: C₂₁H₃₆O₂

Color and Shape: Neat

Molecular weight: 320.51

Ref: 86-MM0222.14

Pregnanediol

CAS: 80-92-2

Pregnanediol (5Beta-Pregnane-3Alpha,20alpha-Diol) is an inactive metabolite of progesterone by reduction at C5, C3, and C20 position.

Formula: C₂₁H₃₆O₂

Purity: 98% - 99.91%

Color and Shape: Solid

Molecular weight: 320.51

Ref: TM-T1688

5-β-Pregnane-3-α,20-α-diol

CAS: 80-92-2

Applications 5β-Pregnane-3α,20α-diol is a metabolite of Progesterone (P755900).
References Beall, et al.: Biochem. J., 31, 35 (1937), Okuda, A., et al.: J. Biol. Chem., 259, 7519 (1984), Russell, D., et al.: Biochemistry, 31, 4737 (1992), Kondo, K., et al.: Eur. J. Biochem., 219, 357 (1994), Westerbacka, J., et al.: J. Clin. Endocrinol. Metab., 88, 4924 (2003),

Formula: C₂₁H₃₆O₂

Color and Shape: White To Off-White

Molecular weight: 320.51

Ref: TR-P705130

5β-Pregnane-3α,20α-diol

Controlled Product

CAS: 80-92-2

5β-Pregnane-3α,20α-diol is a human metabolite of estradiol that has been found to be an active inhibitor of the enzyme activity of GABA transaminase. It has been shown to have therapeutic potential in the prevention and treatment of cervical cancer, as well as other cancers. 5β-Pregnane-3α,20α-diol has also been found to inhibit ovarian activity. The diagnostic method for this metabolite is based on monoclonal antibody (MAb) reactivity with immunosorbent assay (ELISA) and gas chromatography/mass spectrometry (GC/MS). Women who have high values for this metabolite may be at risk for uterine cancer or breast cancer.

Formula: C₂₁H₃₆O₂

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 320.51 g/mol

Ref: 3D-FP27150

5β-Pregnane-3α,20α-diol-d5

Controlled Product

CAS: 80-92-2

Applications Labelled 5β-Pregnane-3α,20α-diol, a metabolite of Progesterone (P755900).
References Beall, et al.: Biochem. J., 31, 35 (1937); Okuda, A. et al.: J. Biol. Chem., 259, 7519 (1984); Russell, D. et al.: Biochemistry, 31, 4737 (1992); Kondo, K. et al.: Eur. J. Biochem.; 219, 357 (1994); Westerbacka, J. et al.: J. Clin. Endocrinol. Metab., 88, 4924 (2003);

Formula: C₂₁H₃₁D₅O₂

Color and Shape: Neat

Molecular weight: 325.54

Ref: TR-P705132