CAS 80214-83-1

Roxithromycin

Description:

Roxithromycin is a semi-synthetic macrolide antibiotic that is primarily used to treat various bacterial infections. It is derived from erythromycin and exhibits a broad spectrum of activity against both Gram-positive and some Gram-negative bacteria. The chemical structure of Roxithromycin includes a lactone ring, which is characteristic of macrolides, and it features a 14-membered ring that contributes to its antibacterial properties. Roxithromycin works by inhibiting bacterial protein synthesis, effectively blocking the growth and reproduction of bacteria. It is typically administered orally and is known for its favorable pharmacokinetic profile, including good tissue penetration and a relatively long half-life, allowing for once-daily dosing in many cases. Common indications for Roxithromycin include respiratory tract infections, skin infections, and certain sexually transmitted infections. While generally well-tolerated, potential side effects may include gastrointestinal disturbances and allergic reactions. As with all antibiotics, it is essential to use Roxithromycin judiciously to minimize the risk of developing antibiotic resistance.

Formula: C₄₁H₇₆N₂O₁₅

InChI: InChI=1S/C41H76N2O15/c1-15-29-41(10,49)34(45)24(4)31(42-53-21-52-17-16-50-13)22(2)19-39(8,48)36(58-38-32(44)28(43(11)12)18-23(3)54-38)25(5)33(26(6)37(47)56-29)57-30-20-40(9,51-14)35(46)27(7)55-30/h22-30,32-36,38,44-46,48-49H,15-21H2,1-14H3/b42-31+/t22-,23-,24+,25+,26-,27+,28+,29-,30+,32-,33+,34-,35+,36-,38+,39-,40-,41-/m1/s1

InChI key: InChIKey=RXZBMPWDPOLZGW-XMRMVWPWSA-N

SMILES: O([C@H]1[C@H](C)[C@@H](O[C@H]2[C@H](O)[C@@H](N(C)C)C[C@@H](C)O2)[C@](C)(O)C[C@@H](C)/C(=N\OCOCCOC)/[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C)[C@H]3C[C@](OC)(C)[C@@H](O)[C@H](C)O3

Synonyms:

• (3R,4S,5S,6R,7R,9R,11S,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-10-{[(2-methoxyethoxy)methoxy]imino}-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one (non-preferred name)
• 5-(3,4,6-Trideoxy-3-Dimethylamino-Beta-D-Xylo-Hexopyranosyloxy)-3-(2,6-Dideoxy-3-C-Methyl-3-O-Methyl-Alpha-L-Ribo-Hexopyranosyloxy)-6,11,12-Trihydroxy-9-(2-Methoxyethoxy)Methoxyimino-2,4,6,8,10,12-Hexamethylpentadecan-13-Olide
• Assoral
• Biaxsig
• Brilid
• Claramid
• Erythromycin, 9-[O-[(2-methoxyethoxy)methyl]oxime], (9E)-
• Forilin
• Overal
• Oxacyclotetradecane, erythromycin deriv.
• Rossitrol
• Rotramin
• Roxacin
• Roxar
• Roxeptin
• Roxibest-A
• Roxid
• Roxid-M
• Roximycin
• Roxithromycin A
• Roxithromycine
• Roxl 150
• Roxxibid
• Roxythromycin
• Ru 28965
• Ru 965
• Rulid
• Rulide
• Surlid
• Xthrocin

Roxithromycin-d7

Controlled Product

CAS: 80214-83-1

Applications Semisynthetic labelled Erythromycin derivative. Antibacterial.
References Jones, R.N., et al.: Antimicrob. Agents Chemother., 24, 209 (1983), Barry, A.L., et al.: Eur. J. Clin. Microbiol., 5, 536 (1986), Grassi, C., et al.: Chemioterapia, 6, 41 (1987),

Formula: C₄₁H₆₉D₇N₂O₁₅

Color and Shape: Neat

Molecular weight: 844.09

Ref: TR-R700852

Roxithromycin

CAS: 80214-83-1

Roxithromycin is a macrolide antibiotic with action on bacterial protein synthesis by binding to the 50S ribosomal subunit and is used for treating respiratory, skin, and soft tissue infections.

Formula: C₄₁H₇₆N₂O₁₅

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 837.05 g/mol

Ref: 3D-AR27766

Roxithromycin

CAS: 80214-83-1

Purity: 95%

Molecular weight: 837.06

Ref: 10-F806737

Roxithromycin RS

CAS: 80214-83-1

Color and Shape: White Solid Crystalline Powder

Ref: 2K-7000990021