CAS 80214-83-1: Roxithromycin

Description:Roxithromycin is a semi-synthetic macrolide antibiotic that is primarily used to treat various bacterial infections. It is derived from erythromycin and exhibits a broad spectrum of activity against both Gram-positive and some Gram-negative bacteria. The chemical structure of Roxithromycin includes a lactone ring, which is characteristic of macrolides, and it features a 14-membered ring that contributes to its antibacterial properties. Roxithromycin works by inhibiting bacterial protein synthesis, effectively blocking the growth and reproduction of bacteria. It is typically administered orally and is known for its favorable pharmacokinetic profile, including good tissue penetration and a relatively long half-life, allowing for once-daily dosing in many cases. Common indications for Roxithromycin include respiratory tract infections, skin infections, and certain sexually transmitted infections. While generally well-tolerated, potential side effects may include gastrointestinal disturbances and allergic reactions. As with all antibiotics, it is essential to use Roxithromycin judiciously to minimize the risk of developing antibiotic resistance.

Formula:C₄₁H₇₆N₂O₁₅

InChI:InChI=1S/C41H76N2O15/c1-15-29-41(10,49)34(45)24(4)31(42-53-21-52-17-16-50-13)22(2)19-39(8,48)36(58-38-32(44)28(43(11)12)18-23(3)54-38)25(5)33(26(6)37(47)56-29)57-30-20-40(9,51-14)35(46)27(7)55-30/h22-30,32-36,38,44-46,48-49H,15-21H2,1-14H3/b42-31+/t22-,23-,24+,25+,26-,27+,28+,29-,30+,32-,33+,34-,35+,36-,38+,39-,40-,41-/m1/s1

InChI key:InChIKey=RXZBMPWDPOLZGW-XMRMVWPWSA-N

SMILES:O=C1OC(CC)C(O)(C)C(O)C(C(=NOCOCCOC)C(C)CC(O)(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)C(OC3OC(C)C(O)C(OC)(C)C3)C1C)C

Synonyms:
(3R,4S,5S,6R,7R,9R,11S,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-10-{[(2-methoxyethoxy)methoxy]imino}-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one (non-preferred name)
5-(3,4,6-Trideoxy-3-Dimethylamino-Beta-D-Xylo-Hexopyranosyloxy)-3-(2,6-Dideoxy-3-C-Methyl-3-O-Methyl-Alpha-L-Ribo-Hexopyranosyloxy)-6,11,12-Trihydroxy-9-(2-Methoxyethoxy)Methoxyimino-2,4,6,8,10,12-Hexamethylpentadecan-13-Olide
Assoral
Biaxsig
Brilid
Claramid
Erythromycin, 9-[O-[(2-methoxyethoxy)methyl]oxime], (9E)-
Forilin
Overal
Oxacyclotetradecane, erythromycin deriv.
See more synonyms
Rossitrol
Rotramin
Roxacin
Roxar
Roxeptin
Roxibest-A
Roxid
Roxid-M
Roximycin
Roxithromycin A
Roxithromycine
Roxl 150
Roxxibid
Roxythromycin
Ru 28965
Ru 965
Rulid
Rulide
Surlid
Xthrocin
Roxithromycin