CAS 80307-12-6

N-succinimidyl 4-maleimidobutyrate

Description:

N-succinimidyl 4-maleimidobutyrate (SMBP) is a chemical compound commonly used in bioconjugation and protein labeling applications. It features a succinimidyl ester functional group, which is reactive towards amine groups, allowing for the formation of stable amide bonds with proteins or other biomolecules. The maleimide group in SMBP is particularly significant as it can selectively react with thiol groups, facilitating the formation of thioether linkages. This dual reactivity makes SMBP a versatile tool in the field of biochemistry and molecular biology, enabling researchers to create targeted conjugates for various applications, including drug delivery, diagnostics, and the development of biosensors. SMBP is typically supplied as a solid and should be handled with care, as it can be sensitive to moisture and light. Its stability and reactivity under physiological conditions make it a valuable reagent for studying protein interactions and modifications. Proper storage and handling are essential to maintain its integrity and effectiveness in experimental protocols.

Formula: C₁₂H₁₂N₂O₆

InChI: InChI=1/C12H12N2O6/c15-8-3-4-9(16)13(8)7-1-2-12(19)20-14-10(17)5-6-11(14)18/h3-4H,1-2,5-7H2

SMILES: C(CC(=O)ON1C(=O)CCC1=O)CN1C(=O)C=CC1=O

N-(γ-Maleimidobutyryloxy)succinimide

CAS: 80307-12-6

A heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. Useful in enzyme immunoassays This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original

Formula: C₁₂H₁₂N₂O₆

Molecular weight: 280.23

Ref: 02-J61850

4-Maleimidobutyric acid N-hydroxysuccinimide ester

CAS: 80307-12-6

GMBS (N-succinimidyl 4-maleimidobutyrate) is an often used heterobifunctional crosslinker, a standard reagent for conjugation of cysteine-containing peptides to carriers.

Formula: C₁₂H₁₂N₂O₆

Purity: 99.3%

Color and Shape: White Powder

Molecular weight: 280.24

Ref: 01-4087894

GMBS

CAS: 80307-12-6

Formula: C₁₂H₁₂N₂O₆

Purity: 97%

Color and Shape: Solid

Molecular weight: 280.2335

Ref: IN-DA003QT6

GMBS

CAS: 80307-12-6

GMBS is a heterobifunctional cross-linker.

Formula: C₁₂H₁₂N₂O₆

Color and Shape: White Solid

Molecular weight: 280.23

Ref: TM-T15395

N-Maleimidobutyryloxysuccinimide ester

CAS: 80307-12-6

N-Maleimidobutyryloxysuccinimide ester

Purity: 98%

Molecular weight: 280.23g/mol

Ref: 54-BICL226

4-Maleimidobutyric Acid N-Succinimidyl Ester

Controlled Product

CAS: 80307-12-6

Stability Hygroscopic, Moisture Sensitive
Applications A short, sulfhydryl and amino reactive heterobifunctional crosslinking reagent. Introduces maleimide groups into IgM.
References Keller, O., et al.: Helv. Chim. Acta., 58, 531 (1975), Fujiwara, K., et al.: J. Immunol. Meth., 112, 77 (1988)

Formula: C₁₂H₁₂N₂O₆

Color and Shape: White To Light Yellow

Molecular weight: 280.23

Ref: TR-M136000

4-Maleimidobutyric acid N-succinimidyl ester

CAS: 80307-12-6

4-Maleimidobutyric acid N-succinimidyl ester is a maleimide compound that can be used as an antimicrobial. It has been shown to have the ability to bind to toll-like receptors, which are proteins found on cells that play a role in immune responses. 4-Maleimidobutyric acid N-succinimidyl ester has been shown to inhibit the growth of bacteria by binding to DNA and crosslinking it. The drug also inhibits protein synthesis and enzyme activities in bacteria.
4-Maleimidobutyric acid N-succinimidyl ester has not been tested for its effects on humans, but it has been shown to be nontoxic in animal studies. This drug may cause cell lysis and thermal expansion, which means that it may be useful in the study of axonal growth and toxicity studies.

Formula: C₁₂H₁₂N₂O₆

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 280.23 g/mol

Ref: 3D-FM24985

2,5-Dioxopyrrolidin-1-yl 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanoate

CAS: 80307-12-6

Formula: C₁₂H₁₂N₂O₆

Purity: 97%

Molecular weight: 280.236

Ref: 10-F324170

N-Succinimidyl 4-Maleimidobutyrate [Cross-linking Reagent]

CAS: 80307-12-6

Formula: C₁₂H₁₂N₂O₆

Purity: >98.0%(HPLC)(N)

Color and Shape: White to Light yellow to Light red powder to crystal

Molecular weight: 280.24

Ref: 3B-S0399

4-Maleimidobutyric Acid N-Hydroxysuccinimide Ester extrapure (GMBS), 99%

CAS: 80307-12-6

Formula: C₁₂H₁₂N₂O₆

Purity: min.99%

Color and Shape: White to light yellow to beige, Powder

Molecular weight: 280.24

Ref: SR-55114