CAS 81-81-2

(±)-Warfarin

Description:

(±)-Warfarin is a synthetic anticoagulant commonly used in the prevention and treatment of thromboembolic disorders. It functions by inhibiting vitamin K epoxide reductase, which is essential for the synthesis of vitamin K-dependent clotting factors in the liver. This compound exists as a racemic mixture of two enantiomers, R and S, with the S-enantiomer being significantly more potent as an anticoagulant. Warfarin is characterized by its relatively low solubility in water, but it is soluble in organic solvents, which facilitates its formulation in various pharmaceutical preparations. The substance has a molecular formula of C19H16O4 and a molecular weight of approximately 308.34 g/mol. Its pharmacokinetics involve oral administration, with a delayed onset of action due to the time required for existing clotting factors to diminish. Warfarin is subject to significant interindividual variability in dosing due to factors such as genetic polymorphisms, dietary vitamin K intake, and interactions with other medications, necessitating careful monitoring of coagulation parameters during therapy.

Formula: C₁₉H₁₆O₄

InChI: InChI=1S/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3

InChI key: InChIKey=PJVWKTKQMONHTI-UHFFFAOYSA-N

SMILES: C(CC(C)=O)(C1=C(O)C=2C(OC1=O)=CC=CC2)C3=CC=CC=C3

Synonyms:

• (.+-.)-Warfarin
• (.+-.)-Warfarin-alcohol
• (RS)-Warfarin
• 1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone
• 3-(1'-Phenyl-2'-acetylethyl)-4-hydroxycoumarin
• 3-(α-Acetonylbenzyl)-4-hydroxycoumarin
• 3-(α-Phenyl-β-acetylethyl)-4-hydroxy-coumarin
• 3-(α-Phenyl-β-acetylethyl)-4-hydroxycoumarin
• 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one
• 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one
• <span class="text-smallcaps">DL</span>-3-(α-Acetonylbenzyl)-4-hydroxycoumarin
• Athrombine-K
• Benzopyran(2H-1)-2-One, 4-Hydroxy-3-(3-Oxo-1- Phenylbutyl)-
• Brumolin
• Circuvit
• Co-Rax
• Compound 42
• Coumadin
• Coumafen
• Coumafene
• Coumaphen
• Coumarin, 3-(α-acetonylbenzyl)-4-hydroxy-
• Coumefene
• DL-3-(α-Acetonylbenzyl)-4-hydroxycoumarin
• Dethmor
• Kumader
• Kumadu
• Kumatox
• Martefarin
• Nsc 59813
• Ratron
• Ratron G
• Rodafarin
• Rodafarin C
• Rodex
• Temus W
• Vampirinip II
• Vampirinip III
• W.A.R.F. 42
• WARF compound 42
• Warf 5
• Warf5
• Warfarin acid
• Warfarina
• Warfarine
• Zoocoumarin
• rac-Warfarin

Warfarin

Controlled Product

CAS: 81-81-2

Formula: C₁₉H₁₆O₄

Molecular weight: 308.33

Ref: ST-EA-CP-W2000

Warfarin

Controlled Product

CAS: 81-81-2

Warfarin (Coumafene) is a vitamin K antagonist, and it works by blocking the action of vitamin K, which is necessary for the synthesis of clotting factors in the liver. Warfarin blocks the action of vitamin K by inhibiting the enzyme gamma-glutamyl carboxylase, which is responsible for the carboxylation of glutamate residues in the clotting factors. This prevents the production of functional clotting factors, leading to an anticoagulant effect.

Formula: C₁₉H₁₆O₄

Purity: 99.35% - 99.99%

Color and Shape: Solid

Molecular weight: 308.3279

Ref: TM-T60736