CAS 81-81-2

(±)-Warfarin

Description:

(±)-Warfarin is a synthetic anticoagulant commonly used in the prevention and treatment of thromboembolic disorders. It functions by inhibiting vitamin K epoxide reductase, which is essential for the synthesis of vitamin K-dependent clotting factors in the liver. This compound exists as a racemic mixture of two enantiomers, R and S, with the S-enantiomer being significantly more potent as an anticoagulant. Warfarin is characterized by its relatively low solubility in water, but it is soluble in organic solvents, which facilitates its formulation in various pharmaceutical preparations. The substance has a molecular formula of C19H16O4 and a molecular weight of approximately 308.34 g/mol. Its pharmacokinetics involve oral administration, with a delayed onset of action due to the time required for existing clotting factors to diminish. Warfarin is subject to significant interindividual variability in dosing due to factors such as genetic polymorphisms, dietary vitamin K intake, and interactions with other medications, necessitating careful monitoring of coagulation parameters during therapy.

Formula:C₁₉H₁₆O₄

InChI:InChI=1S/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3

InChI key:InChIKey=PJVWKTKQMONHTI-UHFFFAOYSA-N

SMILES:C(CC(C)=O)(C1=C(O)C=2C(OC1=O)=CC=CC2)C3=CC=CC=C3

Synonyms:

(.+-.)-Warfarin
(.+-.)-Warfarin-alcohol
(RS)-Warfarin
1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone
3-(1'-Phenyl-2'-acetylethyl)-4-hydroxycoumarin
3-(α-Acetonylbenzyl)-4-hydroxycoumarin
3-(α-Phenyl-β-acetylethyl)-4-hydroxy-coumarin
3-(α-Phenyl-β-acetylethyl)-4-hydroxycoumarin
4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one
4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one
<span class="text-smallcaps">DL</span>-3-(α-Acetonylbenzyl)-4-hydroxycoumarin
Athrombine-K
Benzopyran(2H-1)-2-One, 4-Hydroxy-3-(3-Oxo-1- Phenylbutyl)-
Brumolin
Circuvit
Co-Rax
Compound 42
Coumadin
Coumafen
Coumafene
Coumaphen
Coumarin, 3-(α-acetonylbenzyl)-4-hydroxy-
Coumefene
DL-3-(α-Acetonylbenzyl)-4-hydroxycoumarin
Dethmor
Kumader
Kumadu
Kumatox
Martefarin
Nsc 59813
Ratron
Ratron G
Rodafarin
Rodafarin C
Rodex
Temus W
Vampirinip II
Vampirinip III
W.A.R.F. 42
WARF compound 42
Warf 5
Warf5
Warfarin acid
Warfarina
Warfarine
Zoocoumarin
rac-Warfarin
See more synonyms

Purity (%)

100

products per page.Found 21 products.

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Warfarin Sodium (contains Isopropyl Alcohol)
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 129-06-6
- 81-81-2
Formula:C₁₉H₁₅NaO₄
Purity:>98.0%(HPLC)
Color and Shape:White to Almost white powder to crystal
Molecular weight:330.31
Ref: 3B-W0005
5g
50.00€
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25g
161.00€
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Warfarin, 1mg/ml in Acetonitrile
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 81-81-2
Color and Shape:Colourless
Ref: LP-WAR-1922-1LA
1ml
86.00€
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Warfarin 1.0 mg/ml in Acetonitrile
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 81-81-2
Color and Shape:Colourless
Ref: 61-AMP0638.00-11
1ml
93.00€
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Warfarin
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 81-81-2
Color and Shape:Neat
Ref: 61-FOR0638.00
10mg
302.00€
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WARFARIN RS
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 81-81-2
WARFARIN RS
Formula:C₁₀H₁₆O₄
Molecular weight:200.2316
Ref: 41-ICRS0439
100mg
102.00€
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Warfarin
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 81-81-2
Warfarin
Formula:C₁₉H₁₆O₄
Purity:99.4%
Color and Shape:White
Molecular weight:308.10486
Ref: 47-672
100mg
242.00€
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WARFARIN SODIUM CLATHRATE CRS
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 81-81-2
WARFARIN SODIUM CLATHRATE CRS
Color and Shape:Crystalline Powder. White. Powder.
Ref: 41-Y0000778
10mg
132.00€
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Warfarin
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 81-81-2
Aromatic lactones used as drugs
Formula:C₁₉H₁₆O₄
Color and Shape:White Colorless Crystals
Molecular weight:308.33 g/mol
Ref: 45-1719000
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Warfarin
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 81-81-2
Formula:C₁₉H₁₆O₄
Color and Shape:Off-White Solid
Molecular weight:308.33
Ref: 4Z-W-015
5mg
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100mg
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10mg
343.00€
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25mg
436.00€
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50mg
623.00€
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Warfarin
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 81-81-2
Formula:C₁₉H₁₆O₄
Purity:≥ 98.0% (anhydrous basis)
Color and Shape:White crystalline powder
Molecular weight:308.33
Ref: 7W-GP7659
ne
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Warfarin
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 81-81-2
Warfarin
Purity:≥98%
Molecular weight:308.33g/mol
Ref: 54-BUP21913
200mg
To inquire
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Warfarin 100 µg/mL in Acetonitrile
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 81-81-2
Formula:C₁₉H₁₆O₄
Color and Shape:Colourless
Molecular weight:308.33
Ref: 04-XA17940000AL
1ml
71.00€
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LC PestiMix 9 10 µg/mL in Acetonitrile
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
Color and Shape:Mixture
Ref: 04-A50000809AL
1ml
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Warfarin
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 81-81-2
Color and Shape:Neat
Ref: LP-WAR-1922-10
50mg
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100mg
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10mg
239.00€
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Warfarin
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 81-81-2
Formula:C₁₉H₁₆O₄
Color and Shape:Neat
Molecular weight:308.33
Ref: 86-MM0638.00
100mg
308.00€
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Warfarin
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 81-81-2
Formula:C₁₉H₁₆O₄
Color and Shape:Neat
Molecular weight:308.33
Ref: 04-C17940000
250mg
98.00€
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Rodenticides Mixture 248 100 µg/mL in Acetonitrile
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
Formula:C₃₁H₂₃BrO₃
Color and Shape:Mixture
Molecular weight:523.42
Ref: 04-GS09000248AL
5x1ml
478.00€
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Warfarin
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 81-81-2
Applications Coumarin anticoagulant. Marketed as the racemate; the S-(-)-form is the more potent isomer. Anticoagulant. This compound is a contaminant of emerging concern (CECs).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hagan, E.C., et al.: J. Am. Pharm. Assoc. Sci. Ed., 42, 379 (1953), Bell, R.G., et al.: Biochemistry, 11, 1959 (1972), Valente, J.E., et al.: J. Med. Chem., 20, 1489 (1977), Back, N., et al.: Pharmacol. Res. Commun., 10, 445, (1978), Babhair, S.A., et al.: Anal. Profiles Drug Subs., 14, 423 (1985), Takahashi, H., et al.: Echizen, Clin. Pharmacokinet., 40, 587 (2001),
Formula:C₁₉H₁₆O₄
Color and Shape:Neat
Molecular weight:308.33
Ref: TR-W498500
1g
192.00€
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2500mg
403.00€
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5g
781.00€
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Warfarin - 90%
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 81-81-2
Warfarin is a coumarin that is used as an oral anticoagulant. It has been in use for over 50 years and is still the most widely prescribed drug for the prevention of thromboembolic disease. Warfarin inhibits the synthesis of vitamin K-dependent clotting factors II, VII, IX, and X. This inhibition leads to a prolonged prothrombin time and increased bleeding time. Warfarin also prevents blood from clotting by inhibiting platelet aggregation. The molecular weight of Warfarin is 798 Da, which corresponds to its molecular weight heparin (MWH) binding site.
Warfarin has a narrow therapeutic window and requires careful monitoring by measuring prothrombin time in order to prevent adverse effects such as excessive bleeding or blood clots. Warfarin also interacts with many drugs, including aspirin and non-steroidal anti-inflammatory drugs like ibuprofen, which can lead to increased risk of bleeding
Formula:C₁₉H₁₆O₄
Purity:Min. 95%
Color and Shape:White Slightly Brown Clear Liquid
Molecular weight:308.33 g/mol
Ref: 3D-FW01354
25g
343.00€
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50g
484.00€
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100g
575.00€
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Warfarin
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 81-81-2
Warfarin (Coumafene) is a vitamin K antagonist, and it works by blocking the action of vitamin K, which is necessary for the synthesis of clotting factors in the liver. Warfarin blocks the action of vitamin K by inhibiting the enzyme gamma-glutamyl carboxylase, which is responsible for the carboxylation of glutamate residues in the clotting factors. This prevents the production of functional clotting factors, leading to an anticoagulant effect.
Formula:C₁₉H₁₆O₄
Purity:99.35%
Color and Shape:Solid
Molecular weight:308.3279
Ref: TM-T60736
500mg
89.00€
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