CymitQuimica logo

CAS 81129-83-1

:

Cilastatin sodium

Description:
Cilastatin sodium is a pharmaceutical compound primarily known for its role as a renal dehydropeptidase inhibitor. It is often used in combination with the antibiotic imipenem to prevent the degradation of imipenem in the kidneys, thereby enhancing its efficacy. Cilastatin sodium is a white to off-white crystalline powder that is soluble in water, which facilitates its administration in clinical settings. The compound works by inhibiting the enzyme dehydropeptidase I, which is responsible for the hydrolysis of beta-lactam antibiotics, thus prolonging their action. Cilastatin sodium is typically administered via injection and is used in the treatment of various bacterial infections. Its pharmacokinetics include rapid absorption and distribution, with a relatively short half-life, necessitating careful dosing in therapeutic applications. As with any medication, potential side effects may include gastrointestinal disturbances and allergic reactions, although it is generally well-tolerated when used appropriately.
Formula:C16H26N2O5S·Na
InChI:InChI=1S/C16H26N2O5S.Na/c1-16(2)8-10(16)13(19)18-12(15(22)23)6-4-3-5-7-24-9-11(17)14(20)21;/h6,10-11H,3-5,7-9,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23);/b12-6-;/t10-,11+;/m1./s1
InChI key:InChIKey=IGDRTAHEVZZRHT-QBNHLFMHSA-N
SMILES:C(N/C(=C\CCCCSC[C@@H](C(O)=O)N)/C(O)=O)(=O)[C@@H]1C(C)(C)C1.[Na]
Synonyms:
  • 2-Heptenoic acid, 7-((2-amino-2-carboxyethyl)thio)-2-(((2,2-dimethylcyclopropyl)carbonyl)amino)-, monosodium salt, (R-(R*,S*-(Z)))-
  • 2-Heptenoic acid, 7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-, monosodium salt, (2Z)-
  • 2-Heptenoic acid, 7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-, sodium salt (1:1), (2Z)-
  • Cilastatin natrium
  • Cilastatin sodium salt
  • L 642957
  • Mk 0791
  • Mk 791
  • Primaxin
  • Sodium (Z)-7-(((R)-2-amino-2-carboxyethyl)thio)-2-((S)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoate
  • See more synonyms
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 15 products.