CAS 81131-70-6

Pravastatin sodium

Description:

Pravastatin sodium is a synthetic lipid-lowering agent belonging to the statin class, primarily used to manage hyperlipidemia and reduce the risk of cardiovascular diseases. It functions by inhibiting HMG-CoA reductase, an enzyme crucial for cholesterol biosynthesis in the liver, thereby lowering total cholesterol and low-density lipoprotein (LDL) levels. This compound is characterized by its relatively high solubility in water, which enhances its bioavailability. Pravastatin sodium is typically administered orally and is known for its favorable safety profile, with a lower incidence of muscle-related side effects compared to some other statins. Its pharmacokinetics involve extensive hepatic uptake and metabolism, with a significant portion of the drug being excreted unchanged in the urine. Additionally, pravastatin has been shown to possess anti-inflammatory properties and may improve endothelial function, contributing to its cardiovascular protective effects. As with any medication, it is essential to monitor for potential interactions and contraindications, particularly in patients with liver impairment or those taking other medications that may affect statin metabolism.

Formula: C₂₃H₃₆O₇·Na

InChI: InChI=1S/C23H36O7.Na/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28;/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28);/t13-,14-,16+,17+,18+,19-,20-,22-;/m0./s1

InChI key: InChIKey=RNAREGLVKQKRSG-IYNICTALSA-N

SMILES: C(C[C@H](C[C@H](CC(O)=O)O)O)[C@@H]1[C@]2([C@@H](OC([C@H](CC)C)=O)C[C@H](O)C=C2C=C[C@@H]1C)[H].[Na]

Synonyms:

• 1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-, monosodium salt, [1S-[1α(βS*,δS*),2α,6α,8β(R*),8aα]]-
• 1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-, monosodium salt, (βR,δR,1S,2S,6S,8S,8aR)-
• 1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-, sodium salt (1:1), (βR,δR,1S,2S,6S,8S,8aR)-
• 3β-Hydroxycompactin sodium salt
• Cs 514
• Elisor
• Epastatin sodium
• Eptastatin sodium
• Lipidal
• Lipostat
• Liprevil
• Mevalotin
• Mevan
• Oliprevin
• Prava
• Pravachol
• Pravacol
• Pravaselect
• Pravasin
• Pravasine
• Pravastatin Sodium
• Pravastatin sodium salt
• Pravastin
• Pravator
• Selectin
• Selektine
• Selipran
• Sodium pravastatin
• Sq 31000
• Vasten

Pravastatin Sodium

CAS: 81093-37-0, 81131-70-6

Formula: C₂₃H₃₅NaO₇

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 446.52

Ref: 3B-P1796

Pravastatin Sodium

CAS: 81131-70-6

Color and Shape: Neat

Ref: 61-FOR0503.00

Pravastatin Sodium

CAS: 81131-70-6

Carboxylic acids w/ alcohol function but w/o other oxygen function and their derivatives, nesoi

Formula: C₂₃H₃₆O₇

Color and Shape: White Yellow Crystalline Powder

Molecular weight: 424.2461

Ref: 45-1554206

1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-, sodium salt (1:1), (βR,δR,1S,2S,6S,8S,8aR)-

CAS: 81131-70-6

Formula: C₂₃H₃₅NaO₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 446.5096

Ref: IN-DA0039LL

Pravastatin sodium

CAS: 81131-70-6

Pravastatin sodium (CS-514 (sodium)), an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM.

Formula: C₂₃H₃₅NaO₇

Purity: 97.14%

Color and Shape: White Crystalline Powder

Molecular weight: 446.52

Ref: TM-T0672

Pravastatin sodium

CAS: 81131-70-6

Pravastatin sodium

Purity: ≥95%

Molecular weight: 446.52g/mol

Ref: 54-BUP13672

Pravastatin sodium salt

CAS: 81131-70-6

Formula: C₂₃H₃₅O₇Na·xH₂O

Purity: 97.0 - 102.0 % (anhydrous substance)

Color and Shape: White to light-yellow crystalline powder

Molecular weight: 446.51

Ref: 7W-GK3699

Pravastatin Sodium Salt

CAS: 81131-70-6

Formula: C₂₃H₃₅O₇·Na

Color and Shape: Off-White Solid

Molecular weight: 423.53 22.99

Ref: 4Z-P-132

Pravastatin Sodium

Controlled Product

CAS: 81131-70-6

Formula: C₂₃H₃₅O₇·Na

Color and Shape: Neat

Molecular weight: 446.51

Ref: 86-MM0503.00

Pravastatin sodium

CAS: 81131-70-6

Formula: C₂₃H₃₅O₇·Na

Color and Shape: Neat

Molecular weight: 446.51

Ref: 04-C16286265

Pravastatin sodium

CAS: 81131-70-6

Pravastatin sodium

Purity: 98%

Molecular weight: 446.51g/mol

Ref: 54-BISN0103

Pravastatin Sodium

CAS: 81131-70-6

Stability Hygroscopic
Applications A competitive inhibitor of HMG-CoA reductase. Bioactive metabolite of Mevastatin.
References Serizawa, N., et al.: J. Antibiot., 36, 604 (1983), Yoshino, G., et al.: Lancet, 2, 740 (1986), White, H.D, et al.: N. Engl. J. Med., 343, 317 (2000)

Formula: C₂₃H₃₅O₇·Na

Color and Shape: White To Off-White

Molecular weight: 446.51

Ref: TR-P702000

Pravastatin sodium salt - Bio-X ™

CAS: 81131-70-6

Pravastatin is an HMG-CoA reductase inhibitor that is used to lower lipid levels and manage cardiovascular events such as strokes and myocardial infarction. This drug inhibits HMG-CoA reductase allowing for a reduction in the level of cholesterol.

Formula: C₂₃H₃₅NaO₇

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 446.51 g/mol

Ref: 3D-BP164292

Pravastatin sodium

CAS: 81131-70-6

HMG-CoA reductase inhibitor

Formula: C₂₃H₃₅NaO₇

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 446.51 g/mol

Ref: 3D-FP27125

Pravastatin-d9 Sodium (mixture of 2 diastereomers)

Controlled Product

CAS: 81131-70-6

Applications Pravastatin-d9 Sodium, is the labeled analogue of Pravastatin Sodium (P702000), a competitive inhibitor of HMG-CoA reductase, and bioactive metabolite of Mevastatin.
References Serizawa, N., et al.: J. Antibiot., 36, 604 (1983), Yoshino, G., et al.: Lancet, 2, 740 (1986), White, H.D, et al.: N. Engl. J. Med., 343, 317 (2000)

Formula: C₂₃D₉H₂₆O₇·Na

Color and Shape: Neat

Molecular weight: 455.56

Ref: TR-P702004