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CAS 81131-70-6

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Pravastatin sodium

Description:
Pravastatin sodium is a synthetic lipid-lowering agent belonging to the statin class, primarily used to manage hyperlipidemia and reduce the risk of cardiovascular diseases. It functions by inhibiting HMG-CoA reductase, an enzyme crucial for cholesterol biosynthesis in the liver, thereby lowering total cholesterol and low-density lipoprotein (LDL) levels. This compound is characterized by its relatively high solubility in water, which enhances its bioavailability. Pravastatin sodium is typically administered orally and is known for its favorable safety profile, with a lower incidence of muscle-related side effects compared to some other statins. Its pharmacokinetics involve extensive hepatic uptake and metabolism, with a significant portion of the drug being excreted unchanged in the urine. Additionally, pravastatin has been shown to possess anti-inflammatory properties and may improve endothelial function, contributing to its cardiovascular protective effects. As with any medication, it is essential to monitor for potential interactions and contraindications, particularly in patients with liver impairment or those taking other medications that may affect statin metabolism.
Formula:C23H36O7·Na
InChI:InChI=1S/C23H36O7.Na/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28;/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28);/t13-,14-,16+,17+,18+,19-,20-,22-;/m0./s1
InChI key:InChIKey=RNAREGLVKQKRSG-IYNICTALSA-N
SMILES:C(C[C@H](C[C@H](CC(O)=O)O)O)[C@@H]1[C@]2([C@@H](OC([C@H](CC)C)=O)C[C@H](O)C=C2C=C[C@@H]1C)[H].[Na]
Synonyms:
  • 1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-, monosodium salt, [1S-[1α(βS*,δS*),2α,6α,8β(R*),8aα]]-
  • 1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-, monosodium salt, (βR,δR,1S,2S,6S,8S,8aR)-
  • 1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-, sodium salt (1:1), (βR,δR,1S,2S,6S,8S,8aR)-
  • 3β-Hydroxycompactin sodium salt
  • Cs 514
  • Elisor
  • Epastatin sodium
  • Eptastatin sodium
  • Lipidal
  • Lipostat
  • See more synonyms
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