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CAS 81279-39-2

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5'-DMT-2'-TBDMS-ibu-rG

Description:
5'-DMT-2'-TBDMS-ibu-rG, with the CAS number 81279-39-2, is a modified nucleoside analog that features a 5'-dimethyltrityl (DMT) protective group and a 2'-tert-butyldimethylsilyl (TBDMS) group. This compound is primarily utilized in the field of nucleic acid chemistry, particularly in the synthesis of oligonucleotides. The presence of the DMT group allows for selective protection of the 5' hydroxyl group, facilitating the stepwise synthesis of RNA or DNA strands. The TBDMS group provides stability and protection for the 2' hydroxyl group, which is crucial for maintaining the integrity of the nucleoside during chemical reactions. This compound is characterized by its ability to enhance the solubility and stability of nucleosides, making it valuable in various biochemical applications, including gene synthesis and molecular biology research. Its structural modifications contribute to improved reactivity and compatibility in synthetic pathways, allowing for the development of more efficient and versatile nucleic acid constructs.
Formula:C41H51N5O8Si
InChI:InChI=1S/C41H51N5O8Si/c1-25(2)36(48)44-39-43-35-32(37(49)45-39)42-24-46(35)38-34(54-55(8,9)40(3,4)5)33(47)31(53-38)23-52-41(26-13-11-10-12-14-26,27-15-19-29(50-6)20-16-27)28-17-21-30(51-7)22-18-28/h10-22,24-25,31,33-34,38,47H,23H2,1-9H3,(H2,43,44,45,48,49)/t31-,33-,34-,38-/m1/s1
InChI key:JMCNKJFOIJGYRG-CJEGOSRCSA-N
SMILES:CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O)O[Si](C)(C)C(C)(C)C
Synonyms:
  • N2-Isobutyryl-2''-O-(tert-butyldimethylsilyl)-5''-O-(4,4''-dimethoxytrityl)-gu
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