![(3aS)-2-[(3S)-1-oxidoquinuclidin-1-ium-3-yl]-3a,4,5,6-tetrahydro-3H-benzo[de]isoquinolin-1-one](https://static.cymitquimica.com/cas-image/thumb-webp/387599-3as-2-3s-1-oxidoquinuclidin-1-ium-3-yl-3a-456-tetrahydro-3h-benzo-de-isoquinolin-1-one.webp)
CAS 813425-83-1
:(3aS)-2-[(3S)-1-oxidoquinuclidin-1-ium-3-yl]-3a,4,5,6-tetrahydro-3H-benzo[de]isoquinolin-1-one
Formula:C19H24N2O2
InChI:InChI=1/C19H24N2O2/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-20(19)17-12-21(23)9-7-13(17)8-10-21/h2,4,6,13,15,17H,1,3,5,7-12H2/t13?,15-,17-,21?/m1/s1
InChI key:IQQIWUDYGYXXEA-BGAFOXLKSA-N
SMILES:C1Cc2cccc3c2[C@H](C1)CN([C@@H]1CN2(=O)CCC1CC2)C3=O
Synonyms:- Palonosetron N-Oxide
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Palonosetron Related Compound A
CAS:Lactams not elsewhere specified or includedFormula:C19H24N2O2Color and Shape:White SolidMolecular weight:312.18378Palonosetron N-oxide
CAS:Palonosetron N-oxide: metabolite and potential impurity of 5-HT3 antagonist palonosetron; forms under oxidative stress.Formula:C19H24N2O2Color and Shape:SolidMolecular weight:312.413Palonosetron EP Impurity H (Palonosetron USP Related Compound A, Palonosetron N-Oxide)
CAS:Formula:C19H24N2O2Color and Shape:White To Off-White SolidMolecular weight:312.411H-Benz[de]isoquinolin-1-one, 2,3,3a,4,5,6-hexahydro-2-[(3S)-1-oxido-1-azabicyclo[2.2.2]oct-3-yl]-, (3aS)-
CAS:Formula:C19H24N2O2Purity:95%Color and Shape:SolidMolecular weight:312.4061Palonosetron N-Oxide
CAS:Controlled ProductApplications A metabolite of Palonosetron (P165800).
References Stoltz, R., et al.: Biopharm., Drug Disposition, 25, 329 (2004), Stoltz, R., et al.: J. Clin. Pharmacol., 44, 520 (2004),Formula:C19H24N2O2Purity:>90%Color and Shape:NeatMolecular weight:312.41Palonosetron N-oxide
CAS:Palonosetron N-oxide is a n-oxide of palonosetron that was synthesized by reacting the drug with nitric acid. It is an impurity in the synthesis of palonosetron, which is used to treat severe nausea and vomiting. The solvents used in this reaction are dimethylsulfoxide (DMSO) and water. The parameters involved were temperature, time, and concentration. Impurities were detected using thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC), and mass spectrometry (MS). The chemical structure of Palonosetron N-oxide is shown below: The equation for the synthesis of Palonosetron N-oxide is as follows: 2PALONOSETRON + HNO3 → PN-OXIDE + 2H2O+NOxFormula:C19H24N2O2Purity:Min. 95%Molecular weight:312.41 g/mol
![1H-Benz[de]isoquinolin-1-one, 2,3,3a,4,5,6-hexahydro-2-[(3S)-1-oxido-1-azabicyclo[2.2.2]oct-3-yl]-…](https://static.cymitquimica.com/products/IN/thumb/DA0059QT.jpg)
