CAS 81525-10-2

Nafamostat

Description:

Nafamostat is a synthetic serine protease inhibitor primarily used in medical applications, particularly in the treatment of pancreatitis and as an anticoagulant during certain surgical procedures. It functions by inhibiting various proteases, including trypsin and thrombin, which play critical roles in blood coagulation and inflammation. Nafamostat is characterized by its rapid onset of action and relatively short half-life, necessitating continuous infusion for sustained therapeutic effects. The compound is typically administered intravenously due to its poor oral bioavailability. Its chemical structure includes a unique combination of functional groups that contribute to its inhibitory properties, making it effective in modulating proteolytic activity. Additionally, Nafamostat has garnered attention for its potential antiviral properties, particularly in the context of COVID-19, as it may inhibit viral entry by targeting host cell proteases. However, its use is associated with potential side effects, including bleeding and allergic reactions, necessitating careful monitoring during administration. Overall, Nafamostat represents a valuable therapeutic agent in specific clinical settings.

Formula: C₁₉H₁₇N₅O₂

InChI: InChI=1S/C19H17N5O2/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23/h1-10H,(H3,20,21)(H4,22,23,24)

InChI key: InChIKey=MQQNFDZXWVTQEH-UHFFFAOYSA-N

SMILES: C(=N)(N)C1=CC2=C(C=C(OC(=O)C3=CC=C(NC(=N)N)C=C3)C=C2)C=C1

Synonyms:

• 6-(Aminoiminomethyl)-2-naphthalenyl 4-((aminoiminomethyl)amino)benzoate
• 6-Amidino-2-naphthyl 4-guanidinobenzoate
• 6-Amidino2-naphthyl 4-guanidinobenzoate
• 6-Carbamimidoylnaphthalen-2-Yl 4-[(Diaminomethylidene)Amino]Benzoate
• Benzoic acid, 4-((aminoiminomethyl)amino)-, 6-(aminoiminomethyl)-2-naphthalenyl ester
• Nafamostat [INN]
• Nafamostatum
• Nafamostatum [Latin]
• Nafamstat
• p-Guanidinobenzoic acid ester with 6-hydroxy-2-naphthamidine
• Ronastat

Nafamostat Mesylate

CAS: 81525-10-2, 82956-11-4

Formula: C₁₉H₁₇N₅O₂·2CH₄O₃S

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 539.58

Ref: 3B-N0959

Benzoic acid, 4-[(aminoiminomethyl)amino]-,6-(aminoiminomethyl)-2-naphthalenyl ester

CAS: 81525-10-2

Formula: C₁₉H₁₇N₅O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 347.3706

Ref: IN-DA01DON5

Nafamostat

CAS: 81525-10-2

Formula: C₁₉H₁₇N₅O₂

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 347.37

Ref: 7W-GP2945

Nafamostat

CAS: 81525-10-2

Nafamostat

Purity: 98%

Molecular weight: 347.37g/mol

Ref: 54-OR1030916

Nafamostat

CAS: 81525-10-2

Nafamostat is a synthetic serine protease inhibitor and an anticoagulant used in haemodialysis. It induces apoptosis, inhibiting SARS-CoV-2 and COVID-19.

Formula: C₁₉H₁₇N₅O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 347.37

Ref: TM-T23052

Nafamostat

CAS: 81525-10-2

Formula: C₁₉H₁₇N₅O₂

Molecular weight: 347.38

Ref: 4Z-N-135002

Nafamostat-d4

CAS: 81525-10-2

Formula: C₁₉H₁₃D₄N₅O₂

Molecular weight: 351.40

Ref: 4Z-N-135003

Nafamostat

CAS: 81525-10-2

Nafamostat is a non-peptide inhibitor of the enzyme myeloperoxidase that is involved in the inflammatory response. It has been shown to be effective in treating bowel diseases, such as ulcerative colitis and Crohn's disease, which are characterized by an overproduction of nitric oxide. Nafamostat also inhibits polymorphonuclear leucocytes, which are phagocytic cells that mediate inflammation by releasing reactive oxygen species. Nafamostat has been shown to impair brain functions and cause amnesia in mice when administered intraperitoneally. This drug binds to the toll-like receptor 4 (TLR4) in mouse monoclonal antibody, leading to inhibition of TLR4 signalling and subsequent inhibition of cytokine production by eosinophils. The pharmacological effects of nafamostat are mediated through its ability to inhibit dextran sulfate reductase, an enzyme that catalyzes the

Formula: C₁₉H₁₇N₅O₂

Purity: Min. 95%

Molecular weight: 347.4 g/mol

Ref: 3D-GDA52510