CAS 82956-11-4: Nafamostat mesylate

Description: Nafamostat mesylate is a synthetic serine protease inhibitor primarily used in medical applications, particularly in the treatment of pancreatitis and as an anticoagulant during certain medical procedures. It is characterized by its ability to inhibit various proteases, including trypsin and thrombin, which makes it valuable in managing conditions associated with excessive proteolytic activity. The compound is typically administered intravenously due to its poor oral bioavailability. Nafamostat mesylate is known for its rapid onset of action and relatively short half-life, necessitating continuous infusion in clinical settings. Its chemical structure includes a mesylate group, which enhances its solubility and stability in solution. Additionally, it has garnered attention for potential antiviral properties, particularly in the context of COVID-19, as it may inhibit viral entry by targeting specific proteases involved in the viral life cycle. Overall, Nafamostat mesylate is a versatile compound with significant therapeutic applications, particularly in critical care and experimental treatments.

Formula: C₁₉H₁₇N₅O₂·2CH₄O₃S

InChI: InChI=1S/C19H17N5O2.CH4O3S/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23;1-5(2,3)4/h1-10H,(H3,20,21)(H4,22,23,24);1H3,(H,2,3,4)

InChI key: InChIKey=ZESSXQLDESEKGC-UHFFFAOYSA-N

SMILES: O=C(OC=1C=CC2=CC(=CC=C2C1)C(=N)N)C3=CC=C(C=C3)NC(=N)N.O=S(=O)(O)C

Synonyms:

• (E)-amino({4-[({6-[(Z)-ammonio(imino)methyl]naphthalen-2-yl}oxy)carbonyl]phenyl}imino)methanaminium dimethanesulfonate
• 6-Amidino-2-naphthyl 4-guanidino-benzoate dimethanesulphonate
• 6-Amidino-2-naphthyl p-guanidinobenzoate
• 6-Carbamimidoylnaphthalen-2-Yl 4-[(Diaminomethylidene)Amino]Benzoate Methanesulfonate
• Benzoic acid, 4-[(aminoiminomethyl)amino]-, 6-(aminoiminomethyl)-2-naphthalenyl ester, dimethanesulfonate
• Benzoic acid, 4-[(aminoiminomethyl)amino]-, 6-(aminoiminomethyl)-2-naphthalenyl ester, methanesulfonate (1:2)
• Coahibitor
• Fut 175
• Futhan
• Nafamastat mesylate
• Nafamostat Mesilate
• Nafamostat dimethanesulfonate
• Nafamostat mesylate
• nafamstatmesilate
• 4-Guanidinobenzoic acid 6-amidino-2-naphtyl·2(methanesulfonic acid)
• Nafomastatmesilate
• 6-AMIDINO-2-NAPHTHYL-4-GUANIDINOBENZOATE DIMETHANESULFONATE
• FUT-175, 4-[(Aminoiminomethyl)amino]benzoic acid 6-(aminoiminomethyl)-2-naphthalenyl ester dimethanesulfonate
• 6-AMIDINO-2-NAPHTHYL-4-GUANIDINOENZOATE, MESYLATE
• ester,dimethanesulfonate
• Nafamstat mesylate
• 4-((aminoiminomethyl)amino)-benzoicaci6-(aminoiminomethyl)-2-naphthalenyl
• FUT-175,6-Amidino-2-naphthyl-4-guanidinoenzoate,mesylate

Benzoic acid, 4-[(aminoiminomethyl)amino]-, 6-(aminoiminomethyl)-2-naphthalenyl ester, dimethanesulfonate

CAS: 82956-11-4

• Formula: C₂₁H₂₅N₅O₈S₂
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 539.5819

Nafamostat Mesilate (Fut-175)

CAS: 82956-11-4

• Purity: 98%
• Molecular weight: 539.58g/mol

Nafamostat Mesylate

CAS: 82956-11-4

• Formula: C₁₉H₁₇N₅O₂·2CH₄O₃S
• Molecular weight: 347.38 2*96.11

Nafamostat mesylate

CAS: 82956-11-4

• Purity: ≥98%
• Molecular weight: 539.58g/mol

Nafamostat Mesylate

CAS: 81525-10-2 82956-11-4

• Formula: C₁₉H₁₇N₅O₂·2CH₄O₃S
• Purity: >98.0%(HPLC)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 539.58

Nafamostat mesylate

CAS: 82956-11-4

Nafamostat mesylate (FUT-175), a synthetic serine protease inhibitor, has been used for the treatment of …

• Formula: C₁₉H₁₇N₅O₂·2CH₄O₃S
• Purity: 97.36% - 99.76%
• Color and Shape: Tan To Pale Orange Solid
• Molecular weight: 539.58

Nafamostat mesylate

CAS: 82956-11-4

• Formula: C₁₉H₁₇N₅O₂
• Purity: ≥ 99.0%
• Color and Shape: White to off-white or beige crystalline powder
• Molecular weight: 347.37

Nafamostat Mesylate

CAS: 82956-11-4

Applications A non-peptide proteaseinhibitor. References Ayoyama, T., et al.: Chem. Pharm. Bull., 33, 1458 (1985)

• Formula: C₁₉H₁₇N₅O₂·2CH₄O₃S
• Color and Shape: Neat
• Molecular weight: 539.58

6-[amino(imino)methyl]-2-naphthyl 4-{[amino(imino)methyl]amino}benzoate dimethanesulfonate

CAS: 82956-11-4

• Purity: 98.0%
• Color and Shape: Solid
• Molecular weight: 347.378

Nafamostat mesylate

CAS: 82956-11-4

Kallikrein inhibitor; serine protease inhibitor

• Formula: C₁₉H₁₇N₅O₂·2CH₃SO₃H
• Purity: Min. 98 Area-%
• Color and Shape: White Off-White Powder
• Molecular weight: 539.58 g/mol

Nafamostat mesylate - Bio-X ™

CAS: 82956-11-4

Nafamostat is a broad-spectrum serine protease inhibitor produced by chemical synthesis. Nafamostat is effective through …

• Formula: C₁₉H₁₇N₅O₂•(CH₄O₃S)₂
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 539.58 g/mol