CAS 81840-15-5

Vesnarinone

Description:

Vesnarinone is a synthetic compound primarily recognized for its cardioprotective properties, particularly in the treatment of heart failure. It functions as a positive inotropic agent, enhancing the contractility of the heart muscle without significantly increasing oxygen demand. Vesnarinone is classified as a pyridine derivative and exhibits a unique mechanism of action that involves the inhibition of phosphodiesterase, leading to increased levels of cyclic AMP in cardiac tissues. This results in improved myocardial function and reduced symptoms of heart failure. The compound also possesses vasodilatory effects, contributing to its therapeutic efficacy. In terms of pharmacokinetics, vesnarinone is metabolized in the liver, and its metabolites can have varying biological activities. While it has shown promise in clinical settings, the use of vesnarinone has been limited due to concerns regarding side effects and the availability of alternative therapies. Overall, vesnarinone represents an interesting example of a compound with specific applications in cardiovascular medicine, highlighting the complexity of drug development and the need for ongoing research in this area.

Formula: C₂₂H₂₅N₃O₄

InChI: InChI=1S/C22H25N3O4/c1-28-19-7-3-16(14-20(19)29-2)22(27)25-11-9-24(10-12-25)17-5-6-18-15(13-17)4-8-21(26)23-18/h3,5-7,13-14H,4,8-12H2,1-2H3,(H,23,26)

InChI key: InChIKey=ZVNYJIZDIRKMBF-UHFFFAOYSA-N

SMILES: C(=O)(N1CCN(C=2C=C3C(=CC2)NC(=O)CC3)CC1)C4=CC(OC)=C(OC)C=C4

Synonyms:

• 1-(1,2,3,4-Tetrahydro-2-oxo-6-quinolyl)-4-veratroylpiperazine
• 1-(3,4-Dimethoxybenzoyl)-4-(1,2,3,4-tetrahydro-2-oxo-6-quinolinyl)piperazine
• 2(1H)-Quinolinone, 6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydro-
• 3,4-Dihydro-6-(4-(3,4-dimethoxybenzoyl)-1-piperazinyl)-2(1H)-quinolinone
• 6-(4-(3,4-Dimethoxybenzoyl)-1-piperazinyl)-3,4-dihydro-2(1H)-
• 6-(4-(3,4-Dimethoxybenzoyl)-1-piperazinyl)-3,4-dihydro-2(1H)-quinolone
• 6-[4-(3,4-Dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydro-2(1H)-quinolinone
• 6-[4-(3,4-dimethoxybenzoyl)piperazin-1-yl]-3,4-dihydroquinolin-2(1H)-one
• Arkin
• Arkin-Z
• Brn 5644229
• Ccris 1451
• Drg-0210
• Opc-8212
• Pieranometazine
• Piperazine, 1-(3,4-dimethoxybenzoyl)-4-(1,2,3,4-tetrahydro-2-oxo-6-quinolinyl)-
• Piteranometozine
• Unii-5Cow40Ev8M
• Vesnarinona
• Vesnarinona [Spanish]
• Vesnarinone [USAN:INN:JAN]
• Vesnarinonum
• Vesnarinonum [Latin]

6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydro-2(1h)-quinolinone

CAS: 81840-15-5

Formula: C₂₂H₂₅N₃O₄

Purity: %

Color and Shape: Solid

Molecular weight: 395.4516

Ref: IN-DA008LEB

Vesnarinone

CAS: 81840-15-5

Vesnarinone

Purity: ≥95%

Molecular weight: 395.45g/mol

Ref: 54-BUP16252

Vesnarinone

CAS: 81840-15-5

Vesnarinone (Arkin) (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but

Formula: C₂₂H₂₅N₃O₄

Purity: 96.69% - 98.13%

Color and Shape: Solid

Molecular weight: 395.45

Ref: TM-T3465