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CAS 82034-46-6

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Loteprednol etabonate

Description:
Loteprednol etabonate is a synthetic corticosteroid primarily used in ophthalmology for its anti-inflammatory properties. It is characterized by its ability to reduce inflammation and alleviate symptoms associated with allergic conjunctivitis and other ocular inflammatory conditions. The compound is a derivative of prednisolone, designed to minimize systemic absorption and enhance local efficacy when administered topically. Loteprednol etabonate exhibits a favorable safety profile, with a lower risk of intraocular pressure elevation compared to traditional corticosteroids, making it suitable for short-term use in treating eye conditions. Its mechanism of action involves the inhibition of inflammatory mediators, thereby reducing redness, swelling, and discomfort. The substance is typically formulated as an eye drop solution, allowing for direct application to the affected area. Overall, Loteprednol etabonate is valued for its targeted therapeutic effects and reduced side effects in the management of ocular inflammation.
Formula:C24H31ClO7
InChI:InChI=1S/C24H31ClO7/c1-4-30-21(29)32-24(20(28)31-13-25)10-8-17-16-6-5-14-11-15(26)7-9-22(14,2)19(16)18(27)12-23(17,24)3/h7,9,11,16-19,27H,4-6,8,10,12-13H2,1-3H3/t16-,17-,18-,19+,22-,23-,24-/m0/s1
InChI key:InChIKey=DMKSVUSAATWOCU-HROMYWEYSA-N
SMILES:O(C(OCC)=O)[C@@]1(C(OCCl)=O)[C@]2(C)[C@@](CC1)([C@]3([C@]([C@@H](O)C2)([C@]4(C)C(CC3)=CC(=O)C=C4)[H])[H])[H]
Synonyms:
  • Androsta-1,4-diene-17-carboxylic acid, 17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxo-, chloromethyl ester, (11β,17α)-
  • CDDD 5604
  • Chloromethyl (8xi,9xi,11beta,14xi,17alpha)-17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate
  • chloromethyl (11beta,17alpha)-17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate
  • androsta-1,4-diene-17-carboxylic acid, 17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxo-, chloromethyl ester, (8xi,9xi,11beta,14xi,17alpha)-
  • Loteprednol etabonate
  • P 5604
  • HGP 1
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