CAS 82159-09-9

Epalrestat

Description:

Epalrestat is a pharmaceutical compound primarily used as an aldose reductase inhibitor, which plays a significant role in the management of diabetic complications, particularly diabetic neuropathy. Its mechanism of action involves the inhibition of the enzyme aldose reductase, which is responsible for the conversion of glucose to sorbitol, thereby reducing the accumulation of sorbitol and preventing osmotic and oxidative stress in nerve tissues. Epalrestat is characterized by its relatively low solubility in water, which can affect its bioavailability. The compound is typically administered orally and has been studied for its potential to improve nerve function and alleviate symptoms associated with diabetic neuropathy. Additionally, it has a favorable safety profile, with side effects generally being mild and manageable. Epalrestat's efficacy and safety have been evaluated in various clinical trials, contributing to its acceptance in certain regions for the treatment of diabetic complications. Overall, Epalrestat represents a targeted approach in diabetes management, focusing on mitigating the long-term effects of hyperglycemia on nerve health.

Formula: C₁₅H₁₃NO₃S₂

InChI: InChI=1/C15H13NO3S2/c1-10(7-11-5-3-2-4-6-11)8-12-14(19)16(9-13(17)18)15(20)21-12/h2-8H,9H2,1H3,(H,17,18)/b10-7+,12-8+

InChI key: InChIKey=CHNUOJQWGUIOLD-NFZZJPOKSA-N

SMILES: C(\C(=C\C1=CC=CC=C1)\C)=C\2/C(=O)N(CC(O)=O)C(=S)S2

Synonyms:

• (5Z)-5-[(2E)-2-Methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid
• 2-[(Z)-5-((E)-2-Methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl]acetic acid
• 3-Thiazolidineacetic acid, 5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-, (E,E)-
• 3-Thiazolidineacetic acid, 5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-, (Z,E)-
• 3-Thiazolidineacetic acid, 5-[(2E)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-, (5Z)-
• 3-Thiazolidineacetic acid, 5-[(2E)-2-methyl-3-phenyl-2-propenylidene]-4-oxo-2-thioxo-, (5Z)-
• 5-((1Z,2E)-2-Methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid
• 5-((Z,E)-beta-Methylcinnamylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid
• Eabeth
• Epalrestat [INN]
• Epalrestatum
• Epalrestatum [Latin]
• Kinedak
• Ono 2235
• Sorbistat
• Unii-424Dv0807X
• {(5E)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid
• {(5Z)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid
• (E，E)-5-(2-Methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-3-thiazo-lidineaeetic acid
• Epalresta
• Quinedac
• 2-((E)-5-((E)-2-METHYL-3-PHENYLALLYLIDENE)-4-OXO-2-THIOXOTHIAZOLIDIN-3-YL)ACETIC ACID
• e)-(e
• 5-((1z,2e)-2-methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacet
• Epatrestat
• EPALRESTAT(KINEDAK)
• 5-[(1Z,2E)-2-METHYL-3-PHENYLPROPENYLIDENE]-4-OXO-2-THIOXO-3-THIAZOLIDINEACETICACID(EPALRESTAT)
• (e,e)-2-[5-(2-methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazo lidin-3-yl]acetic acid
• EPALRESTAT
• Epatat
• [5-[(1Z,2E)-2-Methyl-3-phenylallylidene]-4-oxo-2-thioxothiazolidin-3-yl]acetic acid
• OTAVA-BB BB7211260020
• 3-thiazolidineaceticacid,5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo
• 2-[(5Z)-5[(E)-3-PHENIL-2-METHYLPROP-2-ENYLIDENE]-4-OXO-2-THIOXO-3-THIAZOLIDINYL] ACETIC ACID
• He IpaneMa Division

2-[(5Z)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid

CAS: 82159-09-9

Formula: C₁₅H₁₃NO₃S₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 319.3986

Ref: IN-DA0036GD

Epalrestat

CAS: 82159-09-9

Epalrestat (ONO2235), an aldose reductase inhibitor, helps manage diabetic neuropathy symptoms and slows disease progression.

Formula: C₁₅H₁₃NO₃S₂

Purity: 99.2% - 99.54%

Color and Shape: Deep Red Acicular Crystal

Molecular weight: 319.4

Ref: TM-T1458

Epalrestat

CAS: 82159-09-9

Formula: C₁₅H₁₃NO₃S₂

Color and Shape: Dark Orange Solid

Molecular weight: 319.39

Ref: 4Z-E-601

Epalrestat

CAS: 82159-09-9

Epalrestat

Purity: ≥98%

Molecular weight: 319.4g/mol

Ref: 54-BUP17810

Epalrestat

CAS: 82159-09-9

Formula: C₁₅H₁₃NO₃S₂

Molecular weight: 319.40

Ref: 7W-GP0850

Epalrestat

CAS: 82159-09-9

Formula: C₁₅H₁₃NO₃S₂

Purity: >98.0%(T)(HPLC)

Color and Shape: Light yellow to Amber to Dark green powder to crystal

Molecular weight: 319.39

Ref: 3B-E0906

Epalrestat RS

CAS: 82159-09-9

Color and Shape: Yellow To Orange

Ref: 2K-1027800021

Epalrestat

Controlled Product

CAS: 82159-09-9

Applications An aldose reductase inhibitor. It is used in treatment of diabetic neuropathy.
References Terashima, H., et al.: J. Pharmacol. Exp. Ther., 229, 226 (1983), Kikkawa, R., et al.: Diabetologia, 24, 290 (1983), Kojima, K., et al.: Jpn. J. Ophthalmol., 29, 99 (1985),

Formula: C₁₅H₁₃NO₃S₂

Color and Shape: Neat

Molecular weight: 319.40

Ref: TR-E565300

Epalrestat - Bio-X ™

CAS: 82159-09-9

Epalrestat is a carboxylic acid derivative that is used for the treatment of diabetic neuropathy. This drug is an aldose reductase inhibitor and aims to reduce the accumulation of intracellular sorbitol. Studies in rats have shown this drug to improve morphological abnormalities of nerves.

Formula: C₁₅H₁₃NO₃S₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 319.4 g/mol

Ref: 3D-BE164412

Epalrestat

CAS: 82159-09-9

Aldose reductase inhibitor

Formula: C₁₅H₁₃NO₃S₂

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 319.4 g/mol

Ref: 3D-FE22700

Epalrestat

CAS: 82159-09-9

Formula: C₁₅H₁₃NO₃S₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 319.39

Ref: 10-F036565

Epalrestat-d5

Controlled Product

CAS: 82159-09-9

Applications Epalrestat-d5 is the labeled analogue of Epalrestat (E565300), an aldose reductase inhibitor. It is used in treatment of diabetic neuropathy.
References Terashima, H., et al.: J. Pharmacol. Exp. Ther., 229, 226 (1983); Kikkawa, R., et al.: Diabetologia, 24, 290 (1983); Kojima, K., et al.: Jpn. J. Ophthalmol., 29, 99 (1985)

Formula: C₁₅H₈D₅NO₃S₂

Color and Shape: Neat

Molecular weight: 324.43

Ref: TR-E565302