CAS 82159-09-9
:Epalrestat
Description:
Epalrestat is a pharmaceutical compound primarily used as an aldose reductase inhibitor, which plays a significant role in the management of diabetic complications, particularly diabetic neuropathy. Its mechanism of action involves the inhibition of the enzyme aldose reductase, which is responsible for the conversion of glucose to sorbitol, thereby reducing the accumulation of sorbitol and preventing osmotic and oxidative stress in nerve tissues. Epalrestat is characterized by its relatively low solubility in water, which can affect its bioavailability. The compound is typically administered orally and has been studied for its potential to improve nerve function and alleviate symptoms associated with diabetic neuropathy. Additionally, it has a favorable safety profile, with side effects generally being mild and manageable. Epalrestat's efficacy and safety have been evaluated in various clinical trials, contributing to its acceptance in certain regions for the treatment of diabetic complications. Overall, Epalrestat represents a targeted approach in diabetes management, focusing on mitigating the long-term effects of hyperglycemia on nerve health.
Formula:C15H13NO3S2
InChI:InChI=1/C15H13NO3S2/c1-10(7-11-5-3-2-4-6-11)8-12-14(19)16(9-13(17)18)15(20)21-12/h2-8H,9H2,1H3,(H,17,18)/b10-7+,12-8+
InChI key:InChIKey=CHNUOJQWGUIOLD-NFZZJPOKSA-N
SMILES:C(\C(=C\C1=CC=CC=C1)\C)=C\2/C(=O)N(CC(O)=O)C(=S)S2
Synonyms:- (5Z)-5-[(2E)-2-Methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid
- 2-[(Z)-5-((E)-2-Methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl]acetic acid
- 3-Thiazolidineacetic acid, 5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-, (E,E)-
- 3-Thiazolidineacetic acid, 5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-, (Z,E)-
- 3-Thiazolidineacetic acid, 5-[(2E)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-, (5Z)-
- 3-Thiazolidineacetic acid, 5-[(2E)-2-methyl-3-phenyl-2-propenylidene]-4-oxo-2-thioxo-, (5Z)-
- 5-((1Z,2E)-2-Methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid
- 5-((Z,E)-beta-Methylcinnamylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid
- Eabeth
- Epalrestat [INN]
- Epalrestatum
- Epalrestatum [Latin]
- Kinedak
- Ono 2235
- Sorbistat
- Unii-424Dv0807X
- {(5E)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid
- {(5Z)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid
- (E，E)-5-(2-Methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-3-thiazo-lidineaeetic acid
- Epalresta
- Quinedac
- 2-((E)-5-((E)-2-METHYL-3-PHENYLALLYLIDENE)-4-OXO-2-THIOXOTHIAZOLIDIN-3-YL)ACETIC ACID
- e)-(e
- 5-((1z,2e)-2-methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacet
- Epatrestat
- EPALRESTAT(KINEDAK)
- 5-[(1Z,2E)-2-METHYL-3-PHENYLPROPENYLIDENE]-4-OXO-2-THIOXO-3-THIAZOLIDINEACETICACID(EPALRESTAT)
- (e,e)-2-[5-(2-methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazo lidin-3-yl]acetic acid
- EPALRESTAT
- Epatat
- [5-[(1Z,2E)-2-Methyl-3-phenylallylidene]-4-oxo-2-thioxothiazolidin-3-yl]acetic acid
- OTAVA-BB BB7211260020
- 3-thiazolidineaceticacid,5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo
- 2-[(5Z)-5[(E)-3-PHENIL-2-METHYLPROP-2-ENYLIDENE]-4-OXO-2-THIOXO-3-THIAZOLIDINYL] ACETIC ACID
- He IpaneMa Division
- See more synonyms
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Epalrestat
CAS:Formula:C15H13NO3S2Purity:>98.0%(HPLC)(T)Color and Shape:Light yellow to Amber to Dark green powder to crystalMolecular weight:319.39Epalrestat
CAS:Epalrestat (ONO2235), an aldose reductase inhibitor, helps manage diabetic neuropathy symptoms and slows disease progression.Formula:C15H13NO3S2Purity:99.2% - 99.66%Color and Shape:Orange SolidMolecular weight:319.399Epalrestat-d5
CAS:Controlled ProductApplications Epalrestat-d5 is the labeled analogue of Epalrestat (E565300), an aldose reductase inhibitor. It is used in treatment of diabetic neuropathy.
References Terashima, H., et al.: J. Pharmacol. Exp. Ther., 229, 226 (1983); Kikkawa, R., et al.: Diabetologia, 24, 290 (1983); Kojima, K., et al.: Jpn. J. Ophthalmol., 29, 99 (1985)Formula:C15H8D5NO3S2Color and Shape:NeatMolecular weight:324.43Epalrestat
CAS:Controlled ProductApplications An aldose reductase inhibitor. It is used in treatment of diabetic neuropathy.
References Terashima, H., et al.: J. Pharmacol. Exp. Ther., 229, 226 (1983), Kikkawa, R., et al.: Diabetologia, 24, 290 (1983), Kojima, K., et al.: Jpn. J. Ophthalmol., 29, 99 (1985),Formula:C15H13NO3S2Color and Shape:NeatMolecular weight:319.4Epalrestat
CAS:2-((Z)-5-((E)-2-Methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acidFormula:C15H13NO3S2Purity:95%Molecular weight:319.4Epalrestat - Bio-X ™
CAS:Epalrestat is a carboxylic acid derivative that is used for the treatment of diabetic neuropathy. This drug is an aldose reductase inhibitor and aims to reduce the accumulation of intracellular sorbitol. Studies in rats have shown this drug to improve morphological abnormalities of nerves.Formula:C15H13NO3S2Purity:Min. 95%Color and Shape:PowderMolecular weight:319.4 g/molEpalrestat
CAS:Aldose reductase inhibitorFormula:C15H13NO3S2Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:319.4 g/mol
