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CAS 82410-32-0

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Ganciclovir

Description:
Ganciclovir is an antiviral medication primarily used to treat cytomegalovirus (CMV) infections, particularly in immunocompromised patients, such as those with HIV/AIDS or organ transplant recipients. It is a synthetic analog of guanosine and functions by inhibiting viral DNA synthesis. Ganciclovir is characterized by its white to off-white crystalline powder form, which is soluble in water and has a moderate molecular weight. The compound has a specific chemical structure that includes a hydroxymethyl group and a cyclic structure, contributing to its activity against CMV. Its mechanism of action involves selective phosphorylation by viral enzymes, leading to the termination of viral DNA chain elongation. Ganciclovir is typically administered intravenously or orally, and its use may be associated with side effects such as bone marrow suppression, which necessitates careful monitoring of blood counts during treatment. Overall, Ganciclovir is a crucial therapeutic agent in managing viral infections, particularly in vulnerable populations.
Formula:C9H13N5O4
InChI:InChI=1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17)
InChI key:InChIKey=IRSCQMHQWWYFCW-UHFFFAOYSA-N
SMILES:C(OC(CO)CO)N1C2=C(N=C1)C(=O)N=C(N)N2
Synonyms:
  • 2'-Ndg
  • 2'-Nor-2'-deoxyguanosine
  • 2-Amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-6H-purin-6-one
  • 2-Amino-9-(1,3-dihydroxypropan-2-yloxymethyl)-3H-purin-6-one
  • 2-Amino-9-(2-hydroxy-1-hydroxymethyl-ethoxymethyl)-1,9-dihydro-purin-6-one
  • 2-Amino-9-[[(1,3-dihydroxypropan-2-yl)oxy]methyl]-6,9-dihydro-3H-purin-6-one
  • 6H-Purin-6-one, 2-amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-
  • 9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)-methyl)guanine
  • 9-(1,3-Dihydroxy-2-propoxymethyl)guanine
  • Biolf 62
  • See more synonyms
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